S-Nitrosothiols and Nitric Oxide Biology

Patel, Rakesh P.; Yuan, Shuai; Kevil, Christopher G.

doi:10.1016/b978-0-12-804273-1.00004-1

Cited by 7 publications

(6 citation statements)

References 142 publications

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“…Second, in mice carrying a specific knockout for Rac2, a member of the Rho family of small GTPases regulating ROS generation via PHOX, NET formation and nitric oxide (NO) production were significantly impaired (34). Consistently, Patel et al (35) have demonstrated that NO donors induce NET formation. Furthermore, PMA-induced NETosis is dependent on the activation of protein kinase C (PKC) (20).…”

Section: Ros-dependent Net Formationsupporting

confidence: 67%

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Stephan

Fabri

2015

Experimental Dermatology

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Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self-and non-self-stimuli. It has become clear that NETs are potent triggers of inflammation in autoimmune skin diseases. Moreover, the ability of NETs to trap pathogens suggests a crucial role in innate host defense. However, the outcome of the encounter between pathogens and NETs remains highly controversial. Here, we discuss recent insights into the morphology and formation of NETs, their role in skin inflammation and how NETs might contribute to host protection in skin infection.

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Section: Ros-dependent Net Formationsupporting

confidence: 67%

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Stephan

Fabri

2015

Experimental Dermatology

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“…The biological chemistries leading to S-nitrosylation in vivo remain unclear. Oxidation of cysteine thiol, metal-catalyzed transfer of NO, and exchange with small molecular weight (SMW) thiols represent three of the mechanisms that have been proposed to mediate protein S-nitrosylation in biological systems 45 , 46 . S-nitrosoglutathione (GSNO) is an endogenously formed S-nitrosothiol.…”

Section: Signaling Through Protein S-nitrosylationmentioning

confidence: 99%

“…Comprehensive reviews on the chemistry of S‐nitrosocysteine formation have been recently published 46 , 52 , 53 . It is very well documented that endogenous protein S-nitrosylation regulates protein function and biological responses 54 – 59 .…”

Section: Signaling Through Protein S-nitrosylationmentioning

confidence: 99%

Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism

Τενοπούλου¹,

Doulias²

2020

F1000Res

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Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human body. The signaling functions of nitric oxide are accomplished through two primer mechanisms: cGMP-mediated phosphorylation and the formation of S-nitrosocysteine on proteins. This review presents and discusses previous and more recent findings documenting that nitric oxide signaling regulates metabolic activity. These discussions primarily focus on endothelial nitric oxide synthase (eNOS) as the source of nitric oxide.

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“…С возрастом уровень NO в сосудах, производимых эндотелием, снижается, и, таким образом, функция сосудов страдает, вызывая относительную дисфункцию эндотелия, протромбоцитарные и провоспалительные эффекты, а также повышенную пролиферацию гладкой мускулатуры. Как только NO попадает в кровоток, он быстро выводится из организма, связываясь с гемоглобином и другими белками и соединениями и образуют производные NO, включая S-нитрозотиолы, нитрозилгемоглобин и другие растворимые переносчики NO в кровотоке, которые могут быть восстановлены обратно к NO при определенных физиологических условиях [8][9][10][11][12][13][14].…”

Section: Introductionunclassified

Inhaled nitric oxide: well-known and new therapeutic indications

Avdeev,

Tsareva,

Nekludova

et al. 2023

Medicinskij sovet

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The use of nitric oxide is widespread in medical practice. Inhaled form of NO in patients with respiratory disease is especially interesting. As an inhalation therapy, nitric oxide reaches well-ventilated areas of the lungs, having a negligible systemic effect due to its rapid inactivation in the bloodstream. It has long been known that inhaled NO improves oxygenation in various pathological conditions. Low doses of inhaled nitric oxide are known as a vasodilator in patients with pulmonary hypertension, its use is possible even in newborns with hypoxemic respiratory failure and persistent pulmonary hypertension. In turn, high doses are used in the treatment of infectious lung diseases, besides, another surge of scientific interest in nitric oxide arose during the coronavirus pandemic. Although the antimicrobial potential of nitric oxide is widely known, it is little used in clinical practice. Endogenous antimicrobial activity is largely mediated by high local concentrations of NO. Numerous preclinical studies have demonstrated that NO has general static and bactericidal activity against viruses, bacteria, protozoa and fungi/yeast in vitro. Due to the dose-dependent positive and negative effects of NO, safety and efficacy tests of NO and its donors are needed to assess their role in the prevention and treatment of infections. This review provides information on the chemical structure, features of metabolism and delivery of inhaled NO, and also pays special attention to the antimicrobial effect in various diseases of the pulmonological profile.

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S-Nitrosothiols and Nitric Oxide Biology

Cited by 7 publications

References 142 publications

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism

Inhaled nitric oxide: well-known and new therapeutic indications

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