S100A14 protein as diagnostic and prognostic marker in hepatocellular carcinoma

Mohamed, B.; Serag, Waleed M.; Abdelal, Reda Mahamoud; Elsergany, Heba Fadl

doi:10.1186/s43066-019-0015-6

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…AFP concentration in the current study was significantly higher in HCC group when compared to CHCV and control groups, which was in same line with previous studies, found that elevated AFP levels are associated with higher pathological grade (21). AFP measurements showed a statistically significant difference between the studied groups, which increased in HCC in comparison to cirrhosis and the control group (22). The present study revealed that significant decrease in miRNA-23b gene expression level in HCC group when compared to CHCV and control groups.…”

Section: Discussion Discussionsupporting

confidence: 92%

Impact of miR-23b and miR-331 Gene Expressions on HCV-Related Hepatocellular Carcinoma in Egyptian Patients

Omran¹,

Sherif²,

Khalil³

et al. 2023

SGO

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Background: Hepatocellular carcinoma (HCC) is a major type of liver tumor. It represents up to 90% of all liver malignancies. There are currently no reliable tumor markers or imaging technologies that can accurately diagnose early HCC. The use of circulating micro-RNAs (miRNAs or miR) as a potential tool for early detection of HCC has become an emerging area of study. Objectives: This study aimed to evaluate the role of miR-23b and miR-331 as biomarkers in HCC and chronic hepatitis C (CHC) patients. Patients and Methods: This study included 100 subjects, selected from outpatient clinics of Damanhur Oncology Center from 1/1/2020 to 19/12/2021, they were classified into three groups. Group 1 included 40 patients with HCC, group 2 included 40 patients with chronic hepatitis C infection (CHC), and group 3 included 20 healthy control subjects. Complete blood count (CBC), liver function tests, Alfa fetoprotein (AFP) in addition to miR-23b and miR-331 was estimated in the serum of each studied groups. Results: miRNA-23b gene expression level was significantly decreased in the HCC group when compared to the HCV and control groups. On the other hand, miRNA-331 gene expression level showed significantly higher expression level in the HCC group when compared to the HCV and control groups. The miRNA-23b gene expression level showed significantly decreased level associated with increased BCLC stage, increased tumor size, multiplicity. While higher miRNA-331 gene expression level was significantly associated with higher BCLC stage, larger tumor size, multiple lesions. Conclusion: Serum miR-331 and miR-23b are suggested to be predictors for development and complications of HCC.

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Section: Discussion Discussionsupporting

confidence: 92%

Impact of miR-23b and miR-331 Gene Expressions on HCV-Related Hepatocellular Carcinoma in Egyptian Patients

Omran¹,

Sherif²,

Khalil³

et al. 2023

SGO

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“…However, Li et al presented evidence showing that S100A4 in cooperation with collagen I is involved in the development of fibrosis-associated HCC by upregulating stem cell marker genes, for example, Oct-4, Nanog, and SOX2, via RAGE-dependent β-catenin signalling [197]. Recently, S100A14 was introduced as a promising marker, as it was overexpressed in HCC tissue compared with healthy liver tissue and cirrhosis tissue, and therefore might be a sensitive assistant for diagnosis of HCC [198,199].…”

Section: S100 Proteins In Other Cancer Typesmentioning

confidence: 99%

Friend or Foe: S100 Proteins in Cancer

Allgöwer

Kretz

Karstedt

et al. 2020

Cancers

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S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis, proliferation, apoptosis, differentiation, and inflammation. Although the complex network of S100 signalling is by far not fully deciphered, several S100 family members could be linked to a variety of diseases, such as inflammatory disorders, neurological diseases, and also cancer. The research of the past decades revealed that S100 proteins play a crucial role in the development and progression of many cancer types, such as breast cancer, lung cancer, and melanoma. Hence, S100 family members have also been shown to be promising diagnostic markers and possible novel targets for therapy. However, the current knowledge of S100 proteins is limited and more attention to this unique group of proteins is needed. Therefore, this review article summarises S100 proteins and their relation in different cancer types, while also providing an overview of novel therapeutic strategies for targeting S100 proteins for cancer treatment.

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“…Many studies revealed that altering in S100A14 expression is associated with cancer progression and prognosis [10,18,19]. Previous studies have also clearly revealed the presence of S100A14 in serum as it is secreted by cancer cells and exerts extracellular functions [20,21]. Therefore, we aimed in this study to determine the levels of S100A14 protein in serum samples of breast cancer patients and healthy individuals.…”

Section: Discussionmentioning

confidence: 97%

S100A14 serum level and its correlation with prognostic factors in breast cancer

Al-Ashkar

Zetoune

2020

J Egypt Natl Canc Inst

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Background Breast cancer is the most commonly occurring cancer in women worldwide. S100A14 is a novel important member of S100 proteins family. Its importance is due to its role in tumorigenesis and metastasis process. In this study, we aimed to determine serum levels of S100A14 protein in breast cancer patients and healthy individuals to know if it can be suggested as a new biomarker for breast cancer and to reveal whether it is correlated with cancer pathological features. Methods This cross-sectional study was performed in two groups: study group contains 46 breast cancer patients (29 metastatic and 17 non-metastatic) and control group contains 22 healthy women. Enzyme-linked immunoabsorbent assay was performed to determine S100A14 protein levels in samples. Pathological data were obtained for each patient. The data were statistically analyzed using Kruskal-Wallis H, Mann-Whitney U, and Spearman correlation tests. Results S100A14 serum levels were elevated in study group compared with control group (P < 0.05). S100A14 serum levels were significantly increased in distant breast cancer patients compared with regional breast cancer patients (P = 0.001). There was a strong positive correlation between serum S100A14 level and tumor grade (rs = 0.713, P < 0.001). Conclusion Our study indicated that S100A14 serum levels are elevated in breast cancer patients compared with control individuals. High S100A14 serum levels were correlated with poor tumor differentiation so it might have a prognostic significance for breast cancer tumors. The elevation of S100A14 levels in distant breast cancer patients suggests the ability of using serum S100A14 as a biomarker for detection of breast cancer metastasis.

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S100A14 protein as diagnostic and prognostic marker in hepatocellular carcinoma

Cited by 8 publications

References 26 publications

Impact of miR-23b and miR-331 Gene Expressions on HCV-Related Hepatocellular Carcinoma in Egyptian Patients

Impact of miR-23b and miR-331 Gene Expressions on HCV-Related Hepatocellular Carcinoma in Egyptian Patients

Friend or Foe: S100 Proteins in Cancer

S100A14 serum level and its correlation with prognostic factors in breast cancer

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