S100A9 extends lifespan in insulin deficiency

Ramadori, Giorgio; Ljubicic, Sanda; Ricci, Serena; Mikropoulou, Despoina; Brénachot, Xavier; Veyrat-Durebex, Christelle; Aras, Ebru; Ioris, Rafael Maciel; Altirriba, Jordi; Malle, Elisabeth K.; Foell, Dirk; Vogl, Thomas; Coppari, Roberto

doi:10.1038/s41467-019-11498-x

Cited by 15 publications

(31 citation statements)

References 51 publications

(80 reference statements)

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“…This study mainly analyzed the associations between serum S100A9 with the severity and the prognosis in CAP patients based on a retrospective cohort study. The present study mainly found that: Earlier studies found that S100A9 was elevated in several diseases, such as neutrophilic in ammation in asthma, insulin de ciency, atopic dermatitis and Parkinson's disease [17][18][19][20]. Moreover, a report from our laboratory indicated S100A8/S100A9 was increased in COPD patients and is positively associated with in ammatory cytokines [21].…”

Section: Discussionsupporting

confidence: 60%

“…Released of S100A9 would activate several signaling pathways involved in the in ammatory reaction and exert important functions in a great deal of cellular processes [10,[14][15][16]. The previous studies found that S1009A9 is elevated in several diseases, such as neutrophilic in ammation in asthma, insulin de ciency, atopic dermatitis and Parkinson's disease [17][18][19][20]. Moreover, our previous study found that S100A8/S100A9 is increased in COPD patients and is positively associated with in ammatory cytokines [21].…”

Section: Introductionmentioning

confidence: 96%

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The Associations of Serum S100A9 with the Severity and Prognosis In Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study

Liu

Xiang

et al. 2021

Preprint

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Background: Previous studies found that S100A9 may involve in the pathophysiology of community-acquired pneumonia (CAP). However, the role of S100A9 in the CAP was unclear. The goal was to explore the correlations of serum S100A9 with the severity and prognosis of CAP patients based on a retrospective cohort study.Methods: A total of 220 CAP patients and 110 control subjects were recruited. Demographic and clinical data were extracted. Serum S100A9 and inflammatory cytokines were measured.Results: Serum S100A9 was elevated in CAP patients on admission. Furthermore, serum S100A9 was gradually elevated parallelly with CAP severity scores. Inflammatory cytokines were increased and blood routine parameters were changed in CAP patients compared with control subjects. Correlation analysis found that serum S100A9 was positively associated with CAP severity scores, blood routine parameters (WBC, NLR and MON) and inflammatory cytokines. Furtherly, logistical regression demonstrated that there were positive associations between serum S100A9 and CAP severity scores. Besides, the prognosis of CAP was tracked. Serum higher S100A9 on the early stage was positively correlated with the death of risk and hospital stay among CAP patients. Conclusion: Serum S100A9 is positively correlated with the severity of CAP. On admission, serum higher S100A9 elevates the risk of death and hospital stay in CAP patients, suggesting that S100A9 may exert a certain function in the pathophysiology of CAP and regard as a serum diagnostic and managing biomarker for CAP.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 96%

The Associations of Serum S100A9 with the Severity and Prognosis In Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study

Liu

Xiang

et al. 2021

Preprint

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show abstract

“…Therefore, we focused on a functional analysis on the 13 common vitamin D supertargets of the personalized approach together with the genes AQP9, SEMA6B and THBD highlighted by the cohort approach. Based on information provided by the integrative database GeneCards and inspection of the literature [40][41][42] , the predominant cellular location of the proteins encoded by these 16 genes was determined (Fig. 4A).…”

Section: Functional Analysis Of Vitamin D Target Genes From the 13 Cmentioning

confidence: 99%

Common and personal target genes of the micronutrient vitamin D in primary immune cells from human peripheral blood

Hanel

Neme

Malinen

et al. 2020

Sci Rep

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Vitamin D is essential for the function of the immune system. In this study, we treated peripheral blood mononuclear cells (PBMCs) of healthy adults with the biologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) using two different approaches: single repeats with PBMCs obtained from a cohort of 12 individuals and personalized analysis based on triplicates of five study participants. This identified 877 (cohort approach) and 3951 (personalized approach) genes that significantly (p < 0.05) changed their expression 24 h after 1,25(OH)2D3 stimulation. From these, 333 and 1232 were classified as supertargets, a third of which were identified as novel. Individuals differed largely in their vitamin D response not only by the magnitude of expression change but also by their personal selection of (super)target genes. Functional analysis of the target genes suggested the overarching role of vitamin D in the regulation of metabolism, proliferation and differentiation, but in particular in the control of functions mediated by the innate and adaptive immune system, such as responses to infectious diseases and chronic inflammatory disorders. In conclusion, immune cells are an important target of vitamin D and common genes may serve as biomarkers for personal responses to the micronutrient.

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“…Released of S100A9 activates several signaling pathways and exerts important functions in a great deal of cellular processes [ 10 , 14 – 16 ]. The previous studies found that S1009A9 is elevated in several diseases, such as neutrophilic inflammation in asthma, insulin deficiency, atopic dermatitis and Parkinson’s disease [ 17 – 20 ]. In addition, our previous study found that S100A8/S100A9 is increased in COPD patients and positively associated with inflammatory cytokines [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The associations of serum S100A9 with the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study

Liu

Xiang

et al. 2021

BMC Infect Dis

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Background Previous studies found that S100A9 may involve in the pathophysiology of community-acquired pneumonia (CAP). However, the role of S100A9 was unclear in the CAP. The goal was to explore the correlations of serum S100A9 with the severity and prognosis of CAP patients based on a prospective cohort study. Methods A total of 220 CAP patients and 110 control subjects were recruited. Demographic and clinical data were collected. Serum S100A9 and inflammatory cytokines were measured. Results Serum S100A9 was elevated in CAP patients on admission. Serum S100A9 was gradually elevated parallelly with CAP severity scores. Additionally, inflammatory cytokines were increased and blood routine parameters were changed in CAP patients compared with control subjects. Correlation analysis found that serum S100A9 was positively associated with CAP severity scores, blood routine parameters (WBC, NLR and MON) and inflammatory cytokines. Further, logistic regression analysis demonstrated that there were positive associations between serum S100A9 and CAP severity scores. Besides, the prognosis of CAP was tracked. Serum higher S100A9 on the early stage elevated the death of risk and hospital stay among CAP patients. Conclusion Serum S100A9 is positively correlated with the severity of CAP. On admission, serum higher S100A9 elevates the risk of death and hospital stay in CAP patients, suggesting that S100A9 may exert a certain role in the pathophysiology of CAP and regard as a serum diagnostic and managing biomarker for CAP.

show abstract

S100A9 extends lifespan in insulin deficiency

Cited by 15 publications

References 51 publications

The Associations of Serum S100A9 with the Severity and Prognosis In Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study

The Associations of Serum S100A9 with the Severity and Prognosis In Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study

Common and personal target genes of the micronutrient vitamin D in primary immune cells from human peripheral blood

The associations of serum S100A9 with the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study

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