S100B and NSE serum levels in patients with Parkinson's disease

Schaf, Débora Vigevani; Tort, Adriano Bretanha Lopes; Fricke, Daniele; Schestatsky, Pedro; Portela, Luis Valmor; Souza, Diogo O.; Rieder, Carlos Roberto de Mello

doi:10.1016/j.parkreldis.2004.07.002

Cited by 68 publications

(50 citation statements)

References 23 publications

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“…In this context, a number of proteins have been proposed as peripheral biochemical markers of neuronal damage and glial injury/activation, which peripheral assessment may represent a relevant step forward in the diagnostic and monitoring of CNS diseases [5-9]. For this reason, the clinical usefulness of peripheral biochemical markers as complementary tool in the neuropsychiatric evaluation has claimed further attention.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

Chaves

Camozzato

Ferreira

et al. 2010

J Neuroinflammation

159

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BackgroundAlzheimer's disease is the most common dementia in the elderly, and the potential of peripheral biochemical markers as complementary tools in the neuropsychiatric evaluation of these patients has claimed further attention.MethodsWe evaluated serum levels of S100B and neuron-specific enolase (NSE) in 54 mild, moderate and severe Alzheimer's disease (AD) patients and in 66 community-dwelling elderly. AD patients met the probable NINCDS-ADRDA criteria. Severity of dementia was ascertained by the Clinical Dementia Rating (CDR) scale, cognitive function by the Mini Mental State Examination (MMSE), and neuroimage findings with magnetic resonance imaging. Serum was obtained from all individuals and frozen at -70°C until analysis.ResultsBy comparing both groups, serum S100B levels were lower in AD group, while serum NSE levels were the same both groups. In AD patients, S100B levels were positively correlated with CDR scores (rho = 0.269; p = 0.049) and negatively correlated with MMSE scores (rho = -0.33; P = 0.048). NSE levels decreased in AD patients with higher levels of brain atrophy.ConclusionsThe findings suggest that serum levels of S100B may be a marker for brain functional condition and serum NSE levels may be a marker for morphological status in AD.

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Section: Introductionmentioning

confidence: 99%

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

Chaves

Camozzato

Ferreira

et al. 2010

J Neuroinflammation

159

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“…1), indicating a progressive decline of motor coordination in S100B transgenic mice. Previous studies [1][2][3] and the result of Rota-rod test indicated the association of S100B with PD. Therefore, the establishment of brain specific S100B transgenic mouse can be used as an animal model for the research of PD.…”

Section: Resultsmentioning

confidence: 92%

“…Increased levels of S100B were detected in the serum of the patients of PD. 1,2) The expression of S100B in the substantia nigra and striatum of mice has a close relationship with a decreased number of dopaminergic neurons after injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the abdominal cavity of mice. 3) We conclude that S100B has a close relationship with the development of PD, but are still unsure of a concrete mechanism.…”

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confidence: 99%

Metabonomics Study of Brain-Specific Human S100B Transgenic Mice by Using High-Performance Liquid Chromatography Coupled with Quadrupole Time of Flight Mass Spectrometry

Liu

Wang

Zhang

et al. 2011

Biological & Pharmaceutical Bulletin

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Parkinson's disease (PD) is one of the most common neurodegenerative disorders that occur in the elderly. Until now, the cause and mechanism of PD are unknown, making further studies necessary. S100B is a member of a group of Ca 2ϩ -binding protein mostly astrocytederived factor that has been shown to be involved in the maintenance and stimulation of neurons and glia cells by regulating a variety of cellular mechanisms such as proliferation, differentiation and energy metabolism. Increased levels of S100B were detected in the serum of the patients of PD.1,2) The expression of S100B in the substantia nigra and striatum of mice has a close relationship with a decreased number of dopaminergic neurons after injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the abdominal cavity of mice.3) We conclude that S100B has a close relationship with the development of PD, but are still unsure of a concrete mechanism. To reveal the effects of over-expression of S100B on the metabonomics of endogenous components in the brain is very helpful to investigate the mechanism of S100B in the development of PD.Metabonomics, defined as "the quantitative measurement of the dynamic multiparametric metabolic response of living organism to pathophysiological stimulation or genetic modification," 4) combined with multivariate analysis, has been extensively applied to many fields, such as understanding the biochemical basis of diseases, drug toxicity and diagnosis, and treatment of diseases according to the global metabolic profiles in biological fluids (serum, plasma, urine) and tissues.5-8) Metabonomics study was divided into four levels, including target analysis, profiling analysis, fingerprint analysis and metabonomics analysis. In this paper, metabonomics study based on the HPLC/MS-ESI-TOF analysis was applied to understanding the metabolic profiling of S100B transgenic mice and identifying the potential biomarkers relating to S100B protein.Besides of high-field proton nuclear magnetic resonance (NMR) spectroscopy, high-performance liquid chromatography (HPLC) coupled with MS has been widely applied for metabolic profiles of biological samples and reversed-phase (RP) chromatography is the most commonly used separation technique. Although it is impossible to determine the individual level of every single endogenous metabolite in a biofluid, to obtain a metabolic fingerprint, preferably as many metabolites as possible, should be detected. It was found that the most polar components in biological samples would not have been retained on the RP chromatography column, and could not be detected. Hydrophilic interaction liquid chromatography (HILIC) is a complementary method to RP chromatography. HILIC is similar to normal phase chromatography and the separation is based on the distribution between stationary and mobile phases, although it differs with RP chromatography in that aqueous mobile phases can be used. 9)In this paper, with the aim of increasing the number of metabolites to be detected, RP-LC and HILIC were combined. ...

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“…This was reported by Peskind et al (2001) who found that S100B concentrations were increased in mild-to-moderate AD subjects but not in the advanced stage of the disease. Consistent with a transient functional role of S100B in neurodegenerative disease, Schaf et al (2005) reported a correlation of S100B with the Hoehn and Yahr stage of Parkinson’s disease, but no difference per se when S100B was measured in Parkinson’s disease subjects versus controls. Furthermore, Nooijen et al (1997) found no significant difference in concentration of S100B in various types of dementia apart from in subjects with Creutzfeldt–Jakob disease.…”

Section: Introductionmentioning

confidence: 85%

The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults

Lam¹,

Albrecht²,

Takechi³

et al. 2013

Front. Aging Neurosci.

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S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychological performance across a range of cognitive domains in healthy older aged adults. A cohort of 219 participants between the ages of 43 and 84 years (141 female) were recruited. Subjects provided a fasting blood sample for S100B measurement (Mean = 0.24 ng/mL, SD = 0.14) and completed a battery of neuropsychological tests. S100B concentrations (both with and without the covariates of age and sex) were positively associated with the following measures of cognitive performance: digit-symbol coding, Stroop test, and measures of verbal ability. The results from this study show that serum S100B is positively associated with better cognitive performance in healthy older adults.

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S100B and NSE serum levels in patients with Parkinson's disease

Cited by 68 publications

References 23 publications

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

Metabonomics Study of Brain-Specific Human S100B Transgenic Mice by Using High-Performance Liquid Chromatography Coupled with Quadrupole Time of Flight Mass Spectrometry

The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults

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