S100B, Homocysteine, Vitamin B12, Folic Acid, and Procalcitonin Serum Levels in Remitters to Electroconvulsive Therapy: A Pilot Study

Maier, Henk; Helm, Saskia; Toto, Sermin; Moschny, Nicole; Sperling, Wolfgang; Hillemacher, Thomas; Kahl, Kai G.; Jakubovski, Ewgeni; Bleich, Stefan; Frieling, Helge; Neyazi, Alexandra

doi:10.1155/2018/2358451

Cited by 12 publications

(10 citation statements)

References 56 publications

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“…A recent meta-analysis of the 3 first studies that included 51 responders and 73 non-responders found that S100B levels at baseline were significantly elevated in responders ( Shi et al, 2020 ). These findings were similar in patients treated with electroconvulsive therapy, where higher baseline S100B levels were associated with better clinical outcome at both 5 and 30 posttreatment days ( Arts et al, 2006 ) and long-term remission time ( Carlier et al, 2010 ; Maier et al, 2018 ), although no relationship with treatment response was reported ( Kranaster et al, 2014 ). Our findings reinforce these previous data and might suggest that patients with high baseline S100B have an increase in this neurotrophic factor, which may promote the antidepressant response ( Ambrée et al, 2016 ).…”

Section: Discussionsupporting

confidence: 52%

High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers

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Oriolo

Horrillo

et al. 2022

International Journal of Neuropsychopharmacology

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Background The relationship between antidepressant response and glial, inflammatory, and metabolic markers is poorly understood in depression. This study assessed the ability of biological markers to predict antidepressant response in major depressive disorder (MDD). Methods We included 31 MDD outpatients treated with escitalopram or sertraline for 8 consecutive weeks. The Montgomery-Asberg Depression Rating Scale (MADRS) was administered at baseline and at week 4 and 8 of treatment. Concomitantly, blood samples were collected for the determination of serum S100B, CRP, and HDL-C levels. Treatment response was defined as ≥50% improvement in the MADRS score from baseline to either week 4 or 8. Variables associated with treatment response were included in a linear regression model as predictors of treatment response. Results Twenty-seven patients (87%) completed 8 weeks of treatment; 74% and 63% were responders at week 4 and 8, respectively. High S100B and low HDL-C levels at baseline were associated with better treatment response at both time-points. Low CRP levels were correlated with better response at week 4. Multivariate analysis showed that high baseline S100B levels and low baseline HDL-C levels were good predictors of treatment response at week 4 (R 2=0.457, p=0.001), while S100B was at week 8 (R 2=0.239, p=0.011). Importantly, baseline S100B and HDL-C levels were not associated with depression severity and did not change over time with clinical improvement. Conclusions Serum S100B levels appear to be a useful biomarker of antidepressant response in MDD even when considering inflammatory and metabolic markers.

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Section: Discussionsupporting

confidence: 52%

High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers

Navinés

Oriolo

Horrillo

et al. 2022

International Journal of Neuropsychopharmacology

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“…YB-DAO-Hu), respectively. All the assays were measured on an A0018T Microplate reader (Thermo-Fisher Scientific, USA) following the instructions of reagent suppliers [38], [39].…”

Section: Methodsmentioning

confidence: 99%

Chronic Food Antigen-Specific IgG-Mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder

Tao

Xiao

2019

Genomics, Proteomics &Amp; Bioinformatics

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Major depressive disorder (MDD) is the most common nonfatal disease burden worldwide. Systemic chronic low-grade inflammation has been reported to be associated with MDD progression by affecting monoaminergic and glutamatergic neurotransmission. However, whether various proinflammatory cytokines are abnormally elevated before the first episode of depression is still largely unclear. Here, we evaluated 184 adolescent patients who were experiencing their first episode of depressive disorder, and the same number of healthy individuals was included as controls. We tested the serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), IgE, 14 different types of food antigen-specific IgG, histamine , homocysteine, S100 calcium-binding protein B, and diamine oxidase. We were not able to find any significant differences in the serum levels of hs-CRP or TNF-α between the two groups. However, the histamine level of the patients (12.35 μM) was significantly higher than that of the controls (9.73 μM, P < 0.001, Mann–Whitney U test). Moreover, significantly higher serum food antigen-specific IgG positive rates were also found in the patient group. Furthermore, over 80% of patients exhibited prolonged food intolerance with elevated levels of serum histamine, leading to hyperpermeability of the blood–brain barrier , which has previously been implicated in the pathogenesis of MDD. Hence, prolonged high levels of serum histamine could be a risk factor for depressive disorders, and antihistamine release might represent a novel therapeutic strategy for depression treatment.

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“…To control motor seizure activity, a blood pressure cuff was inflated on one extremity-usually on the right lower legbefore muscle relaxation. Study details for the pilot study have already been reported elsewhere (Kleimann et al 2015;Maier et al 2018;Müller et al 2012).…”

Section: Administration Of Ectmentioning

confidence: 99%

Electroconvulsive therapy and adiposity-related parameters in treatment-resistant depressed patients

et al. 2022

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Obesity is often accompanied by major depressive disorder (MDD), and vice versa. Latest research findings suggest the body mass index (BMI) to play a role in antidepressant treatment response in general. Our study aims to examine whether adiposity-related parameters such as BMI, glucose homeostasis, or serum lipids are associated with remission to electroconvulsive therapy (ECT). A pilot study (PS, n = 9) and a glucose study (GS, n = 29) were conducted. Blood was withdrawn directly before and 15 min (GS) as well as 1 h (PS) after the first ECT and directly before the last one (usually an ECT series comprised up to twelve sessions). BMI was associated with remission in the PS (remitters: M = 28, SD = 2.5; non-remitters: M = 22, SD = 2.08; t(7) = 3.325, p < 0.001, d = 0.24) but not in the GS or when pooled together. Glucose and insulin levels increased significantly after a single ECT session (GS: glucose: F (2,25.66) = 39.04, p < 0.001; insulin: PS: F (2,83) = 25.8, p < 0.001; GS: F (2,25.87) = 3.97, p < 0.05) but no chronic effect was detectable. Serum lipids were neither significantly altered after a single ECT session nor during a whole course of ECT. There was no difference between remitters and non-remitters in insulin, glucose, or serum lipid levels. Our study is lacking the differentiation between abdominal and peripheral fat distribution, and the sample size is small. Unexpectedly, BMI, glucose homeostasis, and lipid serum levels did not differ in patients remitting during ECT. In contrast to recently published studies, we cannot confirm the hypothesis that BMI may have an impact on ECT response.

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S100B, Homocysteine, Vitamin B12, Folic Acid, and Procalcitonin Serum Levels in Remitters to Electroconvulsive Therapy: A Pilot Study

Cited by 12 publications

References 56 publications

High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers

High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers

Chronic Food Antigen-Specific IgG-Mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder

Electroconvulsive therapy and adiposity-related parameters in treatment-resistant depressed patients

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