S100β Protein as a Predictor of Poststroke Functional Outcome: A Prospective Study

Branco, João; Oliveira, Sandra de; Sargento-Freitas, João; Costa, Joana Santos; Cordeiro, Gustavo; Cunha, Luı́s; Gonçalves, António Freire; Pinheiro, João Páscoa

doi:10.1016/j.jstrokecerebrovasdis.2018.02.046

Cited by 13 publications

(15 citation statements)

References 23 publications

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“…It's noteworthy that both the two positive results were combined by 2 or 3 small sample size studies and 2 studies involved even showed a high risk of bias, thus the validities of the two results were very limited. S100-β, which is considered as a biomarker of acute brain injury, may have an association with POCD [26]. Our result showed that prophylactic use of GCs had no signi cant effect on the serum level of s100-β, which is consistent with the result of POCD.…”

Section: Discussionsupporting

confidence: 71%

Prophylactic Use of Glucocorticoids and Postoperative Delirium/Cognitive Dysfunction in Adults After Major Surgery: a Meta-Analysis of Randomized Controlled Trials

Xie¹,

Liu²,

Liu³

2020

Preprint

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Objectives. To investigate whether prophylactic use of glucocorticoids (GCs) would affect the incidence of postoperative delirium (POD)/cognitive dysfunction (POCD) after major surgeries. Methods. A systemic review of randomized controlled trials (RCTs) searched from the Pubmed, Cochrane Library, Embase, and Clinical Trials.gov was conducted. Effect of GCs on the incidence of POD/POCD and several secondary outcomes, including s100-β, mechanical ventilation time, length of ICU stay, length of postoperative hospital stay, postoperative cardiac arrhythmia, and adverse outcomes, were analyzed. The Cochrane Collaboration’s risk of bias tool and the GRADE system were used to assess the risk of bias of included studies and the evidence quality of combined results, respectively. Results. There were 726 records detected and only 11 studies were included at last. Six of the 11 RCT studies were categorized as low risk of bias, 3 studies as unclear, and 2 as high. Prophylactic use of GCs didn’t show any significant effect on the incidence of POD/POCD after major surgeries, but the evidence quality of this result was very low. For the secondary outcome, GCs can significantly decrease the level of s100-β, length of ICU stay, length of postoperative hospital stay, and ventilation time, with the evidence quality varied from very low to moderate. For the rest of the secondary outcomes, no significant effect was observed. Conclusion. Prophylactic use of GCs didn’t have a significant effect on the incidence of POD and POCD. However, this result was very uncertain, and more relevant high-quality RCTs are needed.

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Section: Discussionsupporting

confidence: 71%

Prophylactic Use of Glucocorticoids and Postoperative Delirium/Cognitive Dysfunction in Adults After Major Surgery: a Meta-Analysis of Randomized Controlled Trials

Xie¹,

Liu²,

Liu³

2020

Preprint

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“…A total of 16 studies encompassing 6697 patients evaluated fibrinogen in relation to stroke outcome. 15–17,20,21,24–33,47 Nine (56%) studies with a total of 5699 patients reported that high fibrinogen levels were related to poor outcome. 15,24–29,32,47 Fibrinogen levels were measured according to the Clauss method in most studies.…”

Section: Resultsmentioning

confidence: 99%

“…15–17,20,21,24–33,47 Nine (56%) studies with a total of 5699 patients reported that high fibrinogen levels were related to poor outcome. 15,24–29,32,47 Fibrinogen levels were measured according to the Clauss method in most studies. 15,20,25,26,31,32 One study found that fibrinogen levels of >3.7 g/L were associated with poor clinical outcome at 30 days after ischemic stroke with a sensitivity of 79.3% and a specificity of 80.4%.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 6 biomarkers of fibrinolysis were measured in 21 different studies with a total of 3988 patients. 9,11,15–17,20,21,24,26,27,29,33,37–45 Seventeen studies including 3696 patients reported on D-dimer and clinical outcome after ischemic stroke. 9,15–17,21,24,26,27,29,33,37–43 Eight studies determined D-dimer levels with (latex enhanced) immunoturbidimetric assays.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic Hemostasis Biomarkers in Acute Ischemic Stroke

Donkel

Benaddi

Dippel

et al. 2019

ATVB

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“…Apart from refining the CSF-TP reference range, it is also worthwhile to note that many academic research centers are moving toward analysis of other indices to determine the integrity of the blood-brain barrier, the increased intrathecal production, or the abnormal release or sequestration of specific brain proteins. Examples of these other indices include the CSF/serum albumin ratio (Q alb ), 14 the detection of CSF oligoclonal bands, 15 serum neuron-specific enolase, 16 serum S-100β, 17 and CSF tau, 18 amyloid precursor protein, 19 or synuclein. 20 However, for the time being, many of these are specialty tests which are not widely available and subject to the same challenge of defining reference populations.…”

Section: Discussionmentioning

confidence: 99%

A Survey of Cerebrospinal Fluid Total Protein Upper Limits in Canada: Time for an Update?

Bourque

McCudden

Warman‐Chardon

et al. 2019

Can. J. Neurol. Sci.

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ABSTRACT:Background: The antiquated standard reference range of 0.15–0.45 g/L for cerebrospinal fluid total protein (CSF-TP) is well entrenched in medical literature and laboratory operating procedures across the world. Methods: We conducted a web-based survey with a response rate of 34.9% through the listserv of the Canadian Neurological Sciences Federation. Additional laboratory reference data were collated by telephone interview of hospital laboratory technologists across Canada. Results: A total of 142 site responses were obtained: 64.1% from academic/tertiary hospitals and 35.9% from community hospitals. A strong majority (80.4%) of both types of institutions reported using a CSF-TP upper reference limit of 0.45 g/L or less. As a rule, no age adjustments were implemented in CSF-TP-level interpretation. Conclusions: Recent well-powered laboratory reference studies have documented CSF-TP upper reference limits that are above 0.6 g/L starting at age 50, with incremental limits partitioned by subsequent decades of age. The conventional 0.45 g/L limit could lead to false positive results. Our survey suggests there is a need to consider a wide adoption of data-driven, rather than historical, reference values.

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S100β Protein as a Predictor of Poststroke Functional Outcome: A Prospective Study

Cited by 13 publications

References 23 publications

Prophylactic Use of Glucocorticoids and Postoperative Delirium/Cognitive Dysfunction in Adults After Major Surgery: a Meta-Analysis of Randomized Controlled Trials

Prophylactic Use of Glucocorticoids and Postoperative Delirium/Cognitive Dysfunction in Adults After Major Surgery: a Meta-Analysis of Randomized Controlled Trials

Prognostic Hemostasis Biomarkers in Acute Ischemic Stroke

A Survey of Cerebrospinal Fluid Total Protein Upper Limits in Canada: Time for an Update?

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