To inform recommendations for the exercise component of a healthy lifestyle intervention for adults with obesity and treated obstructive sleep apnoea (OSA), we investigated the total energy expenditure (EE) and cardiorespiratory response to weight-supported (cycling) and unsupported (walking) exercise. Individuals with treated OSA and a body mass index (BMI) > 30 kg/m 2 performed an incremental cardiopulmonary exercise test on a cycle ergometer and a treadmill to determine the peak oxygen uptake ðVO 2pk Þ. Participants subsequently completed two endurance tests on each modality, matched at 80% and 60% of the highestVO 2pk determined by the incremental tests, to intolerance. The cardiorespiratory response was measured and total EE was estimated from theVO 2 . Sixteen participants completed all six tests: mean [SD] Contrary to current guidelines, walking might be the preferred training modality to achieve the combination of weight loss and increased cardiorespiratory fitness in adults with obesity and treated OSA.