S127 Chemotherapy sensitises Malignant pleural mesothelioma cells to undergo MSC-TRAIL induced apoptosis: Abstract S127 Table 1.

Abstract

The bronchiectasis severity index derived from these models was composed of prior hospitalisation (5 points), MRC dyspnoea score (0-3 points), FEV 1 (0-3 points), bacterial colonisation (0-3 points) Age (0-6 points) BMI <18.5 (2 points) Exacerbation frequency (0-2 points) and radiological extent (1 point). The AUC for mortality was 0.80 (0.74-0.86) and the AUC for hospitalisation was 0.88 (0.84-0.91). There was a clear difference in exacerbation frequency and quality of life using the St. Georges Respiratory Questionnaire between patients classified as low, intermediate and high risk by the score (p < 0.0001 for all comparisons).In the validation cohorts, the AUC for mortality ranged from 0.81-0.84 and for hospitalisation was AUC 0.80-0.88. Conclusions The bronchiectasis severity index identifies patients at risk of future mortality, hospital admissions and exacerbations. Background Primary ciliary dyskinesia (PCD) is an inherited disease related to ciliary dysfunction, with heterogeneity in clinical presentation, prognosis and ciliary ultrastructure. Our study aimed to comprehensively characterise a large cohort with respect to ciliary ultrastructure, beat frequency, sputum microbiology, mortality and lung function decline. Method A cohort of 100 adult PCD patients was identified at a tertiary respiratory centre. A retrospective analysis of clinical age at presentation and diagnosis alongside ciliary ultrastructure, nasal nitric oxide, beat frequency, sputum microbiology, lung function at diagnosis and follow-up and mortality were recorded. Non-parametric multi-parameter analysis of variance and Spearman rank correlation statistical analysis was performed to identify significant associations with decline in lung function (FEV1%/year). Median duration of follow-up was 7.5years (range 2-30years). Results Overall mortality was 4% (median age of death 55years). 12% of patients had a central pair/transposition defect, 37% missing outer dynein arms, 15% missing inner dynein arms, 28% no arms, and 3% had normal ultrastructure. There was no significant correlation between ciliary ultrastructure, beat frequency (range 0-13.9Hz) and nasal nitric oxide with clinical age at presentation (range 1-26 years) and diagnosis (range 1-72 years) or lung function at presentation and decline with followup. There was additionally no significant association between sputum isolation including Pseudomonas aeruginosa with lung function decline. 44% of patients had Pseudomonas aeruginosa chronic infection. The incidence of NTM colonisation was low (4%). Aspergillus species colonisation was additionally low (5%). The average lung function decline in the cohort was 1.45% FEV1/year. Conclusions Comprehensive characterisation of an adult PCD cohort with ciliary ultrastructure, light microscopy, clinical presentation and follow-up data shows a relatively favourable outcome with optimum care. Ciliary ultrastructure, beat frequency and nasal nitric oxide does not predict prognosis. Contrary to parallel diagnoses such as cystic fibrosis and adult...

Review of the British Thoracic Society Winter Meeting 2013, 4–6 December, London, UK

“…In the ‘mechanisms in carcinogenesis’ spoken session, work from Professor Janes’ group (London) offered some hope for identifying novel treatments for lung cancer36 and pleural mesothelioma,37 as well as the identification of novel targets 38. In the ‘late breaking news session’, we heard the results of Lung-BOOST trial and the MesoVATS trial from Dr Navani (London) and Dr Rintoul (Cambridge), respectively.…”