S1358 Gastrointestinal Symptoms Predict the Outcomes of COVID-19 Infection

Adnan, Darbaz; Deshmukh, Ameya; Khan, Shahab R.; Rempert, Trevor; Dhana, Klodian; Mahdavinia, Mahboobeh; Bishehsari, Faraz

doi:10.14309/01.ajg.0000707480.23480.66

Cited by 4 publications

(5 citation statements)

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“…In a survey by Nausheen Nasir [19] et al in Karachi, Pakistan, disease severity was associated with age older than 60 years (OR 1.92) and having shortness of breath (OR 4.43). In another study, Darbaz A [20] et al in the United States found that patients presenting with gastrointestinal symptoms had higher hospitalization rates, ICU admission, and intubation. In contrast, Preethi Ramachandran [20] et al compared the outcomes in two groups of patients with or without gastrointestinal symptoms and discovered that mortality did not differ between cases and controls (41.9% vs. 37.8%; p = 0.68).…”

Section: Discussionmentioning

confidence: 99%

“…In another study, Darbaz A [20] et al in the United States found that patients presenting with gastrointestinal symptoms had higher hospitalization rates, ICU admission, and intubation. In contrast, Preethi Ramachandran [20] et al compared the outcomes in two groups of patients with or without gastrointestinal symptoms and discovered that mortality did not differ between cases and controls (41.9% vs. 37.8%; p = 0.68). Secondary outcomes, such as length of stay (7.8 vs. 7.9 days; p = 0.87) and need for mechanical ventilation (29% vs. 26.9%; p = 0.82), also showed no statistically significant differences.…”

Section: Discussionmentioning

confidence: 99%

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COVID-19 outcomes associated with clinical and demographic characteristics in patients hospitalized with severe and critical disease in Peshawar

Imran

Uddin

Yousaf³

et al. 2022

Preprint

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Background As a novel disease, understanding the relationship between the clinical and demographic characteristics of coronavirus disease 2019 (COVID-19) patients and their outcome is critical. We investigated this relationship in hospitalized patients in a tertiary healthcare setting. Aims/objectives To study COVID-19 severity and outcomes in relation to clinical and demographic characteristics of in admitted patients Methodology In this cross-sectional study, medical records for 1087 COVID-19 patients were reviewed to extract symptoms, comorbidities, demographic characteristics, and outcomes data. Statistical analyses included the post-stratification chi-square test, independent sample t-test, multivariate logistic regression, and time-to-event analysis. Results The majority of the study participants were >50 years old (67%) and male (59%) and had the following symptoms: fever (96%), cough (95%), shortness of breath (73%), loss of taste (77%), and loss of smell (77%). Regarding worst outcome, multivariate regression analysis showed that these characteristics were statistically significant: shortness of breath (adjusted odds ratio [aOR] 31.3; 95% CI, 11.87–82.53; p < 0.001), intensive care unit (ICU) admission (aOR 28.3; 95% CI,9.0–89.6; p < 0.001), diabetes mellitus (aOR 5.1; 95% CI;3.2–8.2; p < 0.001), ischemic heart disease (aOR 3.4; 95% CI,1.6–7; p = 0.001), nausea and vomiting (aOR 3.3; 95% CI, 1.7–6.6; p = 0.001), and prolonged hospital stay (aOR 1.04; 95% CI, 1.02–1.08; p = 0.001), while patients with rhinorrhea were significantly protected (aOR 0.3; 95% CI, 0.2–0.5; p < 0.001). A Kaplan–Meier curve showed that the symptoms of shortness of breath, ICU admission, fever, nausea and vomiting, and diarrhea increased the risk of mortality. Conclusion Increasing age, certain comorbidities and symptoms, and direct admission to the ICU increased the risk of worse outcomes. Further research is needed to determine risk factors that may increase disease severity and devise a proper risk-scoring system to initiate timely management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COVID-19 outcomes associated with clinical and demographic characteristics in patients hospitalized with severe and critical disease in Peshawar

Imran

Uddin

Yousaf³

et al. 2022

Preprint

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“…Достоверных различий между группами по частоте коморбидных расстройств выявлено не было, не считая того, что у пациентов с гастроэнтерологическими проявлениями значимо чаще выявлялся СД 2 (p=0,0153). Аналогичные данные были выявлены в крупной североамериканской когорте пациентов (921 пациент c COVID-19), показавшей, что частота СД у пациентов с симптомами со стороны ЖКТ почти на 15% выше, чем у лиц без рассматриваемой симптоматики (p<0,001) [31,32]. Данная находка может [19,20,31,32,35].…”

Section: Discussionunclassified

“…Аналогичные данные были выявлены в крупной североамериканской когорте пациентов (921 пациент c COVID-19), показавшей, что частота СД у пациентов с симптомами со стороны ЖКТ почти на 15% выше, чем у лиц без рассматриваемой симптоматики (p<0,001) [31,32]. Данная находка может [19,20,31,32,35]. Механизмы ассоциации между наличием гастроэнтерологической симптоматики и риском неблагоприятных исходов не до конца ясны.…”

Section: Discussionunclassified

Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic

Ianushevich

Маев

Krikheli

et al. 2021

Terapevticheskii arkhiv

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Aim. Assessment of the prevalence and prognostic value of gastroenterological manifestations in patients with COVID-19. Materials and methods. A single-center retrospective cohort study was carried out. Only cases with laboratory confirmed detection of SARS-CoV-2 virus RNA using polymerase chain reaction in oro-/nasopharyngeal smear samples were subject to analysis. Patients with documented (according to anamnestic data and/or according to examination data during hospitalization) organic pathology of the gastrointestinal tract (GIT) and/or hepatobiliary system, malignant neoplasms of any localization, as well as pregnant patients were excluded from the general register of retrospective data. The final cohort was divided into two groups depending on the presence of gastrointestinal symptoms: COVID-19 with gastrointestinal symptoms (cases) and COVID-19 without gastrointestinal symptoms (control). Results. The final sample consisted of 3764 patients, including 2108 (56%) women and 1656 (44%) men. The average age of the subjects included in the analysis was 58.0 years (95% confidence interval CI 48.663.0). In the study cohort, gastroenterological manifestations (alone or in combination) were recorded in 885 (23.51%) patients. Calculation of the odds ratio (OR) of unfavorable and lethal outcomes between the analyzed groups showed that the presence of gastroenterological symptoms significantly increases the chances of lethal outcome in a cohort of elderly and senile patients (OR 1.6817, 95% CI 1.03352.7364; p=0.0364), determines a higher risk of hospitalization or transfer to the intensive care unit (OR 1.2959, 95% CI 1.05471.5922; p=0.0136), development of acute respiratory distress syndrome (OR 1.5952, 95% CI 1.31641.9329; p0.0001), as well as the need for mechanical ventilation (OR 1.2849, 95% CI 1.0771.5329; p=0.0054). Conclusion. The present study has demonstrated that gastroenterological symptoms are detected in about one in four patients infected with the SARS-CoV-2 virus and multiply the risk of adverse and life-threatening complications of COVID-19.

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“…Participants were systematically asked about the presence of overall gastrointestinal symptoms (i.e., abdominal pain, nausea, or vomiting) that they attributed to the SARS-CoV-2 infection. We separated these overall gastrointestinal symptoms from diarrhea since the presence of diarrhea during the acute phase of SARS-CoV-2 infection has been associated with poor hospitalization outcomes and COVID-19 severity [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

Trajectory of Gastrointestinal Symptoms in Previously Hospitalized COVID-19 Survivors: The Long COVID Experience Multicenter Study

Fernández‐de‐las‐Peñas

Torres‐Macho

Guijarro

et al. 2023

Viruses

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This multicenter cohort study used Sankey plots and exponential bar plots to visualize the fluctuating evolution and the trajectory of gastrointestinal symptoms in previously hospitalized COVID-19 survivors during the first 18 months after acute SARS-CoV-2 infection. A total of 1266 previously hospitalized COVID-19 survivors were assessed at four points: hospital admission (T0), at 8.4 months (T1), at 13.2 months (T2), and at 18.3 months (T3) after hospitalization. Participants were asked about their overall gastrointestinal symptoms and particularly diarrhea. Clinical and hospitalization data were collected from hospital medical records. The prevalence of overall gastrointestinal post-COVID symptomatology was 6.3% (n = 80) at T1, 3.99% (n = 50) at T2 and 2.39% (n = 32) at T3. The prevalence of diarrhea decreased from 10.69% (n = 135) at hospital admission (T0), to 2.55% (n = 32) at T1, to 1.04% (n = 14) at T2, and to 0.64% (n = 8) at T3. The Sankey plots revealed that just 20 (1.59%) and 4 (0.32%) patients exhibited overall gastrointestinal post-COVID symptoms or diarrhea, respectively, throughout the whole follow-up period. The recovery fitted exponential curves revealed a decreasing prevalence trend, showing that diarrhea and gastrointestinal symptoms recover during the first two or three years after COVID-19 in previously hospitalized COVID-19 survivors. The regression models did not reveal any symptoms to be associated with the presence of gastrointestinal post-COVID symptomatology or post-COVID diarrhea at hospital admission or at T1. The use of Sankey plots revealed the fluctuating evolution of gastrointestinal post-COVID symptoms during the first two years after infection. In addition, exponential bar plots revealed the decreased prevalence of gastrointestinal post-COVID symptomatology during the first three years after infection.

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S1358 Gastrointestinal Symptoms Predict the Outcomes of COVID-19 Infection

Cited by 4 publications

References 0 publications

COVID-19 outcomes associated with clinical and demographic characteristics in patients hospitalized with severe and critical disease in Peshawar

COVID-19 outcomes associated with clinical and demographic characteristics in patients hospitalized with severe and critical disease in Peshawar

Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic

Trajectory of Gastrointestinal Symptoms in Previously Hospitalized COVID-19 Survivors: The Long COVID Experience Multicenter Study

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