S2386 Acute Upper Gastrointestinal Bleed Due to Gastric Calciphylaxis

Cochrane, Mikayla; Mujumdar, Sahaj; Karaisz, Fred; Chalikonda, Divya; Christensen, Daniel; Kozuch, Patricia; Katz, Leo; Adkins, Christopher; Ambelil, Manju; Henry, Christopher

doi:10.14309/01.ajg.0000783076.41461.0a

Cited by 1 publication

(2 citation statements)

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“…A systematic search of the literature for available case reports related to gastrointestinal manifestations yielded nine case reports, the summary of which is listed in Table 1 [ 3 - 11 ]. Presentation varied between GI bleeding and acute abdomen with pneumoperitoneum, and the most common diagnostic studies utilized were CT of the abdomen or gastrointestinal scope.…”

Section: Discussionmentioning

confidence: 99%

“…The mortality rate is very high, with an estimated six-month mortality of around 57% [ 2 ]. Although it is primarily reported to involve the skin, visceral manifestations have always been reported; it is just that it is rare compared to the extremities, and very few case reports have reported gastrointestinal (GI) manifestations [ 3 - 11 ]. We report a patient with ESKD, who is noncompliant with treatment, with severe systemic calciphylaxis presenting with a parastomal abscess and was found to have ischemic necrosis of the colon.…”

Section: Introductionmentioning

confidence: 99%

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A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review

Chinnappan¹,

Aguirre²,

Marcus³

et al. 2023

Cureus

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Calciphylaxis is an infrequent yet lethal disease often associated with end-stage kidney disease (ESKD). The most common sites include proximal and distal extremities and the trunk, with few reported in the penis and very few as gastrointestinal (GI) disease. We report a case of systemic calciphylaxis in a middle-aged male, presenting with a colostomy leak and parastomal abscess. Workup revealed severe calcification of the intestinal arteries and ischemic colon necrosis. The patient underwent colectomy, antibiotic therapy, regular hemodialysis (HD), and sodium thiosulphate infusion with clinical stability. Histopathology of the colon revealed ischemic necrosis and pericolonic vessel calcification suggestive of calciphylaxis. It is an important differential to be considered in patients with risk factors presenting with symptoms of gastrointestinal hemorrhage and necrosis with perforation.

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Section: Discussionmentioning

confidence: 99%