S24 The Immunoprotective Effect of the Human Immunodeficiency Virus in Delaying the Development of Inflammatory Bowel Disease

Abstract

and hospital charges using STATA 17. Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders. Results: We identified 1,198,839 patients with IBD of which 235,880 patients were matched to those with anxiety. Average age was 52.04 years. There was a significant decrease in inpatient mortality (OR 0.56, CI 0.51-0.62, P , 0.0001) and total cost of hospitalization (-$3,242.13, CI -4,259.55 --2224.70, P , 0.0001), but hospital length of stay increased (0.27 days, CI 0.20-0.34, P , 0.0001) between patients with IBD with cannabis use when compared to IBD patients without cannabis use. Conclusion(s):The different clinical manifestations and symptoms of IBD may cause several psychological changes in patients. Past studies demonstrated that psychological stress and disorders can trigger flares and relapses in patients with IBD. Our study showed that there was a statistically significant decrease in inpatient mortality and hospital LOS for patients with both IBD and anxiety compared to those with only IBD. Anxiety is known to be 2 to 3 times higher in patients with IBD, but it reduces morbidity and mortality. This may be due to the increased surveillance and treatment to this subgroup of patients. Given the known association between IBD and anxiety, clinicians be vigilant in detecting and treating concomitant anxiety as this could lead to better outcomes in this patient population, as our study revealed. Future randomized control trials are needed to further study the impact of anxiety on IBD.