S256 Risk Factors of Colorectal Cancer in Africa: A Systematic Review and Meta-Analysis

Tazinkeng, Nkengeh N.; Pearlstein, Ethan F.; Manda-Mapalo, Martha; Adekunle, Ayooluwatomiwa D.; Sawyer, Kelsey; Bains, Kanwal; Chukwudike, Evaristus S.; Mohamed, Mouhand; Egboh, Stella-Maris C.; Asante, Comfort; Asombang, Akwi W.

doi:10.14309/01.ajg.0000857664.27592.13

Am J Gastroenterol

2022

DOI: 10.14309/01.ajg.0000857664.27592.13

|View full text |Cite

S256 Risk Factors of Colorectal Cancer in Africa: A Systematic Review and Meta-Analysis

Nkengeh N. Tazinkeng

Ethan F. Pearlstein

Martha Manda-Mapalo

et al.

Abstract: Introduction:The United States Preventive Services Taskforce lowered the recommended starting age for colorectal cancer (CRC) screening in average-risk adults from 50 to 45 years due to a rapid increase in young CRC incidence and overall favorable benefit-to-burden ratio in the US. This recommendation has not been widely adopted by other countries partially because the burden of young CRC in these countries is unclear compared to the United States.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The successful transfer of the program from FCD to Addis Ababa University CDT-Africa facilitated country ownership and positioned the local partner institution as a sustainable LMIC training hub. Previous studies on training initiatives for health professionals in Africa have shown the potential to improve competency and performance[30][31][32][33][34], yet there is limited information on competency in clinical trial capacity. The program's success in enhancing participants' pro ciency in clinical trials was notably marked by a signi cant improvement.…”

mentioning

confidence: 99%

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps)

Ejigu,

Fekadu,

Whitty

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Africa's involvement in clinical trials remains very low. Although the crucial role of training initiatives in building clinical trial capacity in Africa has been documented, current efforts fall short as they lack alignment with local contexts. This study aimed to design, develop, implement, and evaluate an innovative clinical trial operations training program for Africa. Methods We developed ClinOps, a novel 10-week clinical trial operations training program for study coordinators in Africa, intending to enhance their expertise in four fundamental areas: designing, conducting, managing, and reporting clinical trials. We used cloud applications to minimize installation of software, whilst maximizing student engagement with the course, VoiceThread, an interactive collaboration and sharing tool allowed interactive content to be accessed offline. Moodle, an open-source learning management system provided a platform to share learning tools, provide one-on-one mentorship, and multidirectional competency assessment strategies including lesson quizzes, forum discussions, asynchronous tutorials, and group assignments. We used Zoom video conferencing application for live tutorials and mentoring, as required. Program effectiveness was evaluated through quantitative pre-post tests, qualitative end-course evaluations, and a comprehensive monitoring and evaluation. We used Wilcoxon rank test to compare pre-post test scores and thematic analysis to analyze the qualitative data. Results In the initial cohort, 88 study coordinators from 19 countries participated, including 56 (64%) females, with 57 (65%) actively employed as study coordinators during the training, and 85 (97%) possessing prior experience in clinical trial roles. Among these, 71 (81%) successfully completed the course, with 69 (97%) also completing the post-course assessment. Post-training scores demonstrated substantial improvement compared to pre-training scores in each competency area, including in designing (mean rank = 36.27 vs 12.20; Z = 6.799, p < 0.001), conducting (mean rank = 31.78 vs 8.0; Z = -6.68, p < 0.001), managing (mean rank = 36.89 vs 9.83; Z = -6.813, p < 0.001), and reporting (mean rank = 16.94 vs 3.0; Z = -4.897, p < 0.001) clinical trials. The program adhered to training best practices, encompassing alignment with local priorities, country ownership, pedagogic innovation, institutional capacity building, sustainability, and ongoing partnerships. Participants acknowledged the program for its structure, content, relevance to their current roles, and the overall delivery methods. Conclusion The ClinOps program, a clinical trial operations training initiative for Africa developed by experts from academia and product development partners, significantly enhanced participants' competency in clinical trials. Transferring the program to a local institution promoted country ownership and established the local partner institution as a sustainable clinical trial training hub for Africa. To effectively build clinical trials capacity in Africa, training initiatives should offer comprehensive competency in designing, conducting, managing, and reporting trials tailored to local contexts.

show abstract

mentioning

confidence: 99%

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps)

Ejigu,

Fekadu,

Whitty

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

S256 Risk Factors of Colorectal Cancer in Africa: A Systematic Review and Meta-Analysis

Cited by 1 publication

References 0 publications

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps)

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps)

Contact Info

Product

Resources

About