S2602 The Mischievous Pills

Ramos-Marquez, Reyshley; Pagán-Torres, Hendrick; Santiago-Rivera, Loscar

doi:10.14309/01.ajg.0000783940.84346.d0

Am J Gastroenterol

2021

DOI: 10.14309/01.ajg.0000783940.84346.d0

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S2602 The Mischievous Pills

Reyshley Ramos-Marquez¹,

Hendrick Pagán-Torres²,

Loscar Santiago-Rivera³

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Cefalexin

2021

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Drug induced autoimmune-like hepatitis: case reportA 73-year-old man developed drug induced autoimmune-like hepatitis (DIAIH) during the treatment with cefalexin for complicated urinary tract infection.The man, who had a medical history of uncontrolled diabetes mellitus type 2, metabolic syndrome and coronary artery disease, presented with three days of jaundice and right upper quadrant abdominal pain. He did not report any use of herbal or natural supplements. However, he completed cefalexin [cephalexin; dosage and route not stated] therapy for complicated urinary tract infection. Physical examination was remarkable for jaundiced skin, icteric sclera and abdominal tenderness. Laboratory results showed elevated levels of AST, ALT, ALP and total bilirubin. Serology revealed an elevated IgG levels and positive for antinuclear antibody (ANA). Liver biopsy showed foci of portal tract expansion by a mononuclear inflammatory infiltrate with scattered plasma cells and focal bile duct damage suggestive of interphase hepatitis. These findings were consistent with DIAIH.The patient was recommended with unspecified steroid therapy. Because of his comorbidities and side effects of steroids, he did not undergo treatment with steroids. At three months follow up, his symptoms were resolved.

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Cefalexin

2021

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S2602 The Mischievous Pills

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