S2706 Metastatic Breast Cancer Presenting as Acute Liver Failure

Calogero, Cristina; Arastu, Sanaa; Grodsky, Michael; Ambelil, Manju; Halegoua-DeMarzio, Dina

doi:10.14309/01.ajg.0000712872.40549.34

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“…Age, family history, mutation, lifestyle, obesity, and other factors play a significant role in the development of breast cancer ( 2 ). Aside from these risk factors, the mortality rate of breast cancer patients has been linked to a wide range of other diseases ( 3 ). Thus, it is critical to understand the molecular relationship between breast cancer and other related comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Quercetin activates vitamin D receptor and ameliorates breast cancer induced hepatic inflammation and fibrosis

Gowda

Shiragannavar

Puttahanumantharayappa

et al. 2023

Front. Nutr.

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AimsTo explore the hepatoprotective role of quercetin and its novel molecular mechanism of action on breast cancer associated hepatic inflammation and fibrosis via Vitamin D receptor (VDR).Main methodsWe used Ehrlich Ascites Carcinoma (mouse mammary carcinoma) model for our in-vivo experiments and human breast cancer cell lines for in-vitro assays. We inoculated 1.5 × 106 Ehrlich ascites carcinoma cells into female Swiss albino mice. Quercetin (50 mg/kg) was administered intraperitoneally for 15 days. Liver enzymes activity was determined using a spectrophotometric assay. The hallmarks of inflammation and fibrosis were determined using Immunohistochemistry. The effect of quercetin on tumor formation was elucidated using human breast cancer cell lines and chick chorioallantoic membrane assay. Docking study was performed to explore the binding mode of quercetin with VDR.Key findingsIn EAC tumor-bearing mice, cell numbers, tumor volume, body weight and liver weight were dramatically increased, while they significantly decreased in mice treated with quercetin. Additionally, the peritoneal neo-angiogenesis was also significantly suppressed in the quercetin-treated mice, compared to the control. In addition, quercetin treated EAC tumor bearing mice had lower levels of liver enzymes, decreased hepatic inflammation and fibrosis compared with EAC tumor bearing mice. Docking study confirmed VDR-quercetin interaction. Furthermore, in-vitro assays and chick chorioallantoic membrane assay revealed the Vitamin D mimicking effect of quercetin.SignificanceDietary flavonoid, quercetin could act as a promising therapeutic drug to suppress the breast cancer induced tumor angiogenesis, hepatic inflammation, and fibrosis possibly via activation of VDR.

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Section: Introductionmentioning

confidence: 99%