Pubic hair removal is a body modification practice done worldwide for different socio-cultural reasons, which is more common in women than in men, more common in younger than in older people, and more common in sexually active people than in abstinent individuals. Since there is no medical indication for genital epilation and depilation, with a few exceptions, there is only very limited evidence in the literature about the methods used and their risks. In order to provide users with guidance from a dermatological perspective on the use of different procedures and associated risks, the existing data were collected, analyzed and evaluated in a systematic literature search. For this purpose, a total of 290 articles in the English-and German-language scientific literature were identified in databases (PubMed, Google Scholar) according to defined search strategies, and 61 publications with scientific significance were identified after assessing relevance. It became clear that depilation methods (shaving, trimming, chemical depilation) are used more frequently compared to epilation methods (waxing, sugaring, mechanical epilation, electro-epilation, laser, intense pulsed light, drug epilation). The different risks and undesirable effects were analyzed in a method-associated manner and prophylactic strategies to avoid complications were developed.