1993
DOI: 10.1007/bf01209876
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S3.5 Apoptosis of Burkitt's lymphoma cells via Gb3/CD77 a neutral glycolipid antigen

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Cited by 120 publications
(201 citation statements)
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“…16,17 VT-1 has thereby been mooted as a potential delivery system for toxin-based therapy of CD77-expressing lymphoma: indeed, a range of BL cell lines have been shown to die on exposure to the holotoxin in culture. 9,18 In addition to the ribosome-inactivating properties of the A chain, it was found that B chain pentamer ± when present at sufficiently high concentration ± was, of itself, able to deliver a death signal to BL cells. 18 Subsequent studies using the 38.13 antibody indicated that the cross-linking of CD77 initiated an intracellular signaling cascade (involving a rise in cytosolic Ca 2+ and the generation of ceramide) which culminated in the induction of apoptosis.…”
Section: Introductionmentioning
confidence: 99%
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“…16,17 VT-1 has thereby been mooted as a potential delivery system for toxin-based therapy of CD77-expressing lymphoma: indeed, a range of BL cell lines have been shown to die on exposure to the holotoxin in culture. 9,18 In addition to the ribosome-inactivating properties of the A chain, it was found that B chain pentamer ± when present at sufficiently high concentration ± was, of itself, able to deliver a death signal to BL cells. 18 Subsequent studies using the 38.13 antibody indicated that the cross-linking of CD77 initiated an intracellular signaling cascade (involving a rise in cytosolic Ca 2+ and the generation of ceramide) which culminated in the induction of apoptosis.…”
Section: Introductionmentioning
confidence: 99%
“…9,18 In addition to the ribosome-inactivating properties of the A chain, it was found that B chain pentamer ± when present at sufficiently high concentration ± was, of itself, able to deliver a death signal to BL cells. 18 Subsequent studies using the 38.13 antibody indicated that the cross-linking of CD77 initiated an intracellular signaling cascade (involving a rise in cytosolic Ca 2+ and the generation of ceramide) which culminated in the induction of apoptosis. 9,19 Thus it appeared that therapeutic attack on CD77-expressing lymphoma independent of VT-1 A chain might now be feasible.…”
Section: Introductionmentioning
confidence: 99%
“…Stx also contains five B subunits that carry the binding property of holotoxin to cell surface receptors, such as Gb3 and globotetraosyl ceramide (Gb4). It has been shown that Stx can cause apoptosis in Daudi cells (Burkitt lymphoma cell line) by a pathway independent of its effect on protein synthesis (Mangeney et al 1993). It has been shown that the B subunit alone is enough to induce apoptosis, suggesting that the glycolipid receptor is the major mediator of this effect (O'Loughlin and RobinsBrowne 2001).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to having a direct effect on protein synthesis, protein toxins can also induce DNA cleavage and cause apoptosis-like changes in cells (Jones et al 2000;Suzuki et al 2000). Accumulated evidence suggests that Stx also induces apoptosis in several cell lines including Vero (Inward et al 1995), Burkitt's lymphoma (Mangeney et al 1993), ACHN; human renal tubular epithelium-derived cell (Taguchi et al 1998) and astrocytoma , although the precise mechanisms of Stx-induced apoptotic signal pathways remain unclear (Nicholson 1999). Moreover, cell type specificity for the apoptotic signaling pathway has been demonstrated (Jones et al 2000).…”
Section: Introductionmentioning
confidence: 99%
“…Evidence for a relationship between globotriaosylceramide expression and apoptosis in B lymphocytes (Mangeney et al, 1995) and Burkitt lymphoma cells (Mangeney et al, 1993) has been provided. More recently, it has been shown that apoptosis induced in HuT78 human lymphoma cells by Fas ligation or short-chain ceramide administration is mediated by GD3 ganglioside synthesis and can be prevented by GluCer synthase inhibition (De Maria et al, 1997).…”
Section: Discussionmentioning
confidence: 99%