S3194 Metformin: A Therapeutic Adjunct for Patients With Inflammatory Bowel Disease?

Ali, Farhan; Reddy, Vidhya; Raza, M. Ali; Srinivas, Sowmya; Kamjula, Pallavi; Steimle, Cassandra; Khan, Hafiz; Sappati, Raja R.; Winton, Brittney; Akula, Shilpa

doi:10.14309/01.ajg.0000714824.10034.8a

Cited by 2 publications

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“…While little is known about these taxa, a relationship between a carbohydrate-rich diet and succinate-utilizing bacteria has been previously discussed, 46 with D. succinatiphilus being a well-known species in this category. Additionally, Ruminococcus torques, a known mucin degrader, 47 previously linked to IBD risk 48 and identified as a significant contribution in a Crohn's Disease microbiome-risk score, 49 was notably enriched in Indo-Canadians. Deeper investigations should explore the role of specific R. torques strains in the gut and its implications in IBD should be explored further.…”

Section: Microbiomes Of Indian Migrantsmentioning

confidence: 99%

The transition from a non-westernized to westernized gut microbiome in Indian-Immigrants and Indo-Canadians is associated with dietary acculturation

D’Aloisio,

Ballal,

Ghosh

et al. 2024

Preprint

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Objective: This study investigates the gut microbiome of Indians residing in India, Indian immigrants in Canada, and Canadians of Indian ancestry to understand the impact of westernization on their gut. Given the higher risk of Inflammatory Bowel Disease (IBD) among Indo-Canadians, these results provide insight into how westernization of the gut microbiome may influence incidence of IBD. Design: Stool samples were collected from healthy Indians in India, Immigrants born in India, Indo-Canadians, plus Canadian-borne individuals with European descent and Euro-Immigrants as non-Indian/westernized controls (N = 174).16S and shotgun sequencing compared microbial taxa and functional profiles across groups. Dietary and demographic data were collected to assess lifestyle patterns. Results: The microbiome of Indians and Indo-Immigrants were found to be distinct from westernized groups, with high abundances of Prevotella spp. and CAZymes known to facilitate the breakdown of plant-based foods, reflecting their traditional high complex carbohydrate diet. The Indian microbiome also showed characteristics of high bacterial cell turnover, pathogenic potential and stress tolerance, indicating their gut may be better primed to handle stressors on the gut. Indo-Canadians exhibited a transitional gut microbiome, harbouring taxa both common to Indians and westernized groups, which followed a pattern of increasing dietary acculturation. Conclusions: The transition from a non-westernized to westernized microbiome in Canadian-borne Indian migrants highlights the significant influence that the westernized lifestyle and dietary acculturation has on the gut microbiome. Considering globalization and immigration to westernized countries is occurring at a rapid rate, with 40.6% of the Canadian population made up of first- and second-generation immigrants,1 future research should investigate the health implications that such microbiome transitions have on immigrant populations and newly industrialized nations.

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Section: Microbiomes Of Indian Migrantsmentioning

confidence: 99%

The transition from a non-westernized to westernized gut microbiome in Indian-Immigrants and Indo-Canadians is associated with dietary acculturation

D’Aloisio,

Ballal,

Ghosh

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

The transition from a non-westernized to westernized gut microbiome in Indian-Immigrants and Indo-Canadians is associated with dietary acculturation

D’Aloisio,

Ballal,

Ghosh

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Indian immigration to westernized countries has surged in recent years, with this demographic facing a higher risk of Inflammatory Bowel Disease (IBD) after migration. Studying the gut microbiome is crucial to understanding the factors contributing to IBD, yet Indians remain underrepresented in microbiome research, Objective: This study investigates the gut microbiome of Indians residing in India, Indian immigrants in Canada, and Canadians of Indian ancestry to understand the impact of westernization on their gut. Given the higher risk of IBD among Indo-Canadians, these results provide insight into how westernization of the gut microbiome may influence incidence of IBD. Stool samples were collected from healthy Indians in India, Indian Immigrants in Canada, Indo-Canadians, plus Canadian-borne individuals with European descent and Euro-Immigrants as non-Indian/westernized controls (N = 174). 16S rRNA gene and shotgun sequencing compared microbial taxa and functional profiles across groups. Dietary and demographic data were collected to assess lifestyle patterns. Results: Indians and Indo-Immigrants had distinct gut microbiotas from westernized groups, with high abundances of Prevotella spp. and a CAZyme profile reflecting their traditional high complex carbohydrate diet. The Indian microbiome also showed characteristics of high bacterial cell turnover, pathogenic potential, and stress tolerance, indicating their gut may be better primed to handle stressors on the gut. Indo-Canadians displayed a transitional microbiome towards westernization, which followed a pattern of increasing dietary acculturation. Conclusions: The shift from a non-westernized to westernized microbiome in Indo-Canadians highlights the significant influence that westernization and dietary acculturation has on the gut microbiome. Given that 44% of the Canadian population is made up of first- and second-generation immigrants and westernized practices are being adopted worldwide, future research should investigate the health implications that such microbiome transitions have on immigrant populations and newly industrialized nations.

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S3194 Metformin: A Therapeutic Adjunct for Patients With Inflammatory Bowel Disease?

Cited by 2 publications

References 0 publications

The transition from a non-westernized to westernized gut microbiome in Indian-Immigrants and Indo-Canadians is associated with dietary acculturation

The transition from a non-westernized to westernized gut microbiome in Indian-Immigrants and Indo-Canadians is associated with dietary acculturation

The transition from a non-westernized to westernized gut microbiome in Indian-Immigrants and Indo-Canadians is associated with dietary acculturation

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