S8 from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis

Anstine, Lindsey J.; Majmudar, Parth R.; Aponte, Amy; Singh, Salendra; Zhao, Ran; Weber-Bonk, Kristen L.; Abdul‐Karim, Fadi W.; Valentine, Mitchell; Seachrist, Darcie D.; Grennel-Nickelson, Katelyn E.; Cuellar-Vite, Leslie; Sizemore, Gina M.; Sizemore, Steven T.; Webb, Bryan M.; Thompson, Cheryl L.; Keri, Ruth A.

doi:10.1158/0008-5472.22549883

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2023

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“…Ultimately, osteogenesis of dental follicle cells is inhibited (51). SOX9, the most extensively studied SOX family member, was both a downstream target and an inhibitor of the Wnt/β-catenin signaling pathway (116).…”

Section: Inhibitorsmentioning

confidence: 99%

The recent progress of peptide regulators for the Wnt/β-catenin signaling pathway

et al. 2023

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Wnt signaling plays an important role in many biological processes such as stem cell self-renewal, cell proliferation, migration, and differentiation. The β-catenin-dependent signaling pathway mainly regulates cell proliferation, differentiation, and migration. In the Wnt/β-catenin signaling pathway, the Wnt family ligands transduce signals through LRP5/6 and Frizzled receptors to the Wnt/β-catenin signaling cascades. Wnt-targeted therapy has garnered extensive attention. The most commonly used approach in targeted therapy is small-molecule regulators. However, it is difficult for small-molecule regulators to make great progress due to their inherent defects. Therapeutic peptide regulators targeting the Wnt signaling pathway have become an alternative therapy, promising to fill the gaps in the clinical application of small-molecule regulators. In this review, we describe recent advances in peptide regulators for Wnt/β-catenin signaling.

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Section: Inhibitorsmentioning

confidence: 99%