Sa1135 - Baseline Impedance on High-Resolution Impedance Manometry Correlates with Severity of Eosinophilic Esophagitis Endoscopic Reference Score

Manu, Kavya H.; Aceves, Seema S.; Valasek, Mark A.; Kunkel, David C.

doi:10.1016/s0016-5085(18)31216-2

Cited by 2 publications

(4 citation statements)

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“…In the same year, Hosaka et al [48] described 18 patients with EoE who had undergone HRM: 3 had normal peristalsis, 7 achalasia, 3 IEM, 2 EGJOO or JE, and 1 DES. Manu et al [49] found that, among 16 EoE patients, 9 had normal peristalsis, 6 IEM, and 1 EGJOO.…”

Section: Studies On Esophageal High-resolution Manometrymentioning

confidence: 99%

Systematic Review: esophageal motility patterns in patients with eosinophilic esophagitis

Visaggi

Ghisa

Barberio

et al. 2022

Digestive and Liver Disease

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Section: Studies On Esophageal High-resolution Manometrymentioning

confidence: 99%

Systematic Review: esophageal motility patterns in patients with eosinophilic esophagitis

Visaggi

Ghisa

Barberio

et al. 2022

Digestive and Liver Disease

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“…Ghisa et al66 described 5 patients with OGJOO, 2 of whom responded both histologically and symptomatically to medical therapy (PPI and corticosteroid); 1 initially responded to corticosteroids but subsequently required PD and 2 were refractory to medical management until PD was performed, at which point response to steroid treatment was observed. Finally, 2 cases of OGJOO were described as part of larger cohorts, but without specific focus on this finding 51,64. No patients with OGJOO underwent posttreatment physiology assessment.…”

Section: Resultsmentioning

confidence: 99%

“…Outflow obstruction at the LOS was reported in 2% (17/802) of all patients included. 51,56,57,60,63,64,66 An important factor in the diagnosis of OGJOO is to establish whether there is a relationship between this finding with symptoms, and in turn, its clinical relevance. 15 No studies describe a temporal association between symptom occurrence and OGJOO in patients with EoE.…”

Section: Ogjoomentioning

confidence: 99%

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Assessment of Esophageal Motility in Patients With Eosinophilic Esophagitis

Sykes

Fairlamb

Fox

et al. 2022

Journal of Clinical Gastroenterology

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Eosinophilic esophagitis (EoE) is a chronic, immunemediated condition causing esophageal symptoms, particularly dysphagia. Despite the important progress in the treatment of EoE, a significant proportion of patients continue to report symptoms that negatively impact quality of life. Esophageal manometry is used to assess motility and function, but is not routinely used in EoE. We aimed to systematically review and describe current literature evaluating esophageal manometry in EoE. Forty-eight studies meeting the criteria were identified, describing 802 patients. Using standard water swallow protocols, the proportion of abnormalities detected was not dissimilar to other populations, apart from disorders of esophago-gastric outflow, which were found in 5%. Twelve studies described pretreatment and posttreatment manometry, with motility normalization after pharmacological therapy reported in 20%. Early, brief panesophageal pressurization was described in a number of studies and was more prevalent in the few studies utilizing additional provocation testing. Reports in the literature regarding temporal relationships between manometric findings and symptoms are variable. Esophageal manometry may be capable of detecting clinically relevant changes to esophageal function in EoE. Possible mechanisms are altered neuromuscular function because of secretory products of EoE and/or fibroinflammatory processes, manifesting as pressurization because of altered esophageal compliance. Some changes may be reversible with therapy. Drawing strong conclusions from the literature is difficult, with bias toward case reports and retrospective observation. Adaptations to assessment protocols to include provocation testing may provide more robust evaluation and detect clinically relevant, subtle changes in esophageal function, earlier within the patient pathway.

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Sa1135 - Baseline Impedance on High-Resolution Impedance Manometry Correlates with Severity of Eosinophilic Esophagitis Endoscopic Reference Score

Cited by 2 publications

References 0 publications

Systematic Review: esophageal motility patterns in patients with eosinophilic esophagitis

Systematic Review: esophageal motility patterns in patients with eosinophilic esophagitis

Assessment of Esophageal Motility in Patients With Eosinophilic Esophagitis

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