2016
DOI: 10.1016/s0016-5085(16)31265-3
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Sa1765 Incidental Finding of Germline CDH1 Mutations: Implications for Clinical Management

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“…Individuals with a pathogenic variant of CDH1 , but without family history of gastric cancer, pose a unique challenge. There is limited evidence on endoscopic surveillance of these patients, and one small series found that despite no family history of gastric cancer and negative endoscopic evaluation, 50% of patients had SRCC on surgical pathology[38]. It remains to be determined if these patients truly have decreased gastric cancer risk and reduced prevalence compared to CDH1 carriers with a strong family history of gastric cancer[9,14-16].…”
Section: Role Of Endoscopy In Patients With a Pathogenic Cdh1 Variantmentioning
confidence: 99%
“…Individuals with a pathogenic variant of CDH1 , but without family history of gastric cancer, pose a unique challenge. There is limited evidence on endoscopic surveillance of these patients, and one small series found that despite no family history of gastric cancer and negative endoscopic evaluation, 50% of patients had SRCC on surgical pathology[38]. It remains to be determined if these patients truly have decreased gastric cancer risk and reduced prevalence compared to CDH1 carriers with a strong family history of gastric cancer[9,14-16].…”
Section: Role Of Endoscopy In Patients With a Pathogenic Cdh1 Variantmentioning
confidence: 99%