Sa1838 - The Clinical and Circulating Inflammatory Cytokines Effects of Probiotic Containing Lactobacillus and Bifidobacterium Strains in Patients with Colorectal Cancer: A Randomized Double Blind Controlled Trial

Ali, Raja Affendi Raja; Zaharuddin, Liyana; Chan, Seow-Neng; Wong, Zhiqin; Ngiu, Chai Soon; Mokhtar, Norfilza Mohd

doi:10.1016/s0016-5085(18)31661-5

Cited by 6 publications

(5 citation statements)

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“…Nevertheless, probiotics exert many favorable health outcomes by increasing good gut microbiota composition, reducing adherence of pathobionts, strengthening gut epithelial permeability, helping in the regulation of immune response, insulin signaling, and energy metabolism. In general, probiotics are safe, well-tolerated, and proven to be beneficial for various diseases, such as metabolic disorders, inflammatory bowel disease, and colorectal cancer (Saez-Lara et al, 2015;Sáez-Lara et al, 2016;Ali et al, 2018;Zaharuddin et al, 2019).…”

Section: Probiotics As a Potential Preventive Strategy In Women With Gdmmentioning

confidence: 99%

Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential

Hasain

Mokhtar

Kamaruddin

et al. 2020

Front. Cell. Infect. Microbiol.

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151

132

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Section: Probiotics As a Potential Preventive Strategy In Women With Gdmmentioning

confidence: 99%

Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential

Hasain

Mokhtar

Kamaruddin

et al. 2020

Front. Cell. Infect. Microbiol.

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151

132

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“…Following the above inclusion and exclusion criteria, 507 articles (ongoing studies, unexpectedly terminated trials, noncancer patients, not oral probiotic use, in vitro studies, nonchemotherapy studies, and reviews) and 38 duplicate articles were removed after carefully reading their titles and abstract, leaving only 51 articles. After reading the remaining articles, 39 additional studies were further excluded because of that 12 studies did not include cancer patients or they were not receiving chemotherapy (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), two did not include oral probiotic use (38,39), 20 had no record of diarrhea or oral mucositis in patients (40-59) (18 of them did not include diarrhea or oral mucositis indicators (40)(41)(42)(43)(44)(45)(46)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59), and the other two studies only recorded the frequency of diarrhea or oral mucositis rather than the number of patients who had the adverse reactions (47, 48)), and five were not randomized controlled trials (60)(61)(62)(63)(64). Finally, 12 articles were selected for the meta-analysis.…”

Section: Literature Screening and Population Characteristicsmentioning

confidence: 99%

Oral Administration of Probiotics Reduces Chemotherapy-Induced Diarrhea and Oral Mucositis: A Systematic Review and Meta-Analysis

et al. 2022

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BackgroundChemotherapy generally causes serious diarrhea and oral mucositis in cancer patients, and subsequently affects treatment. Oral administration of probiotics provides a therapeutic choice to address these limitations. This study aims to conduct a systematic review and meta-analysis on the efficacy of oral probiotic use in the management of the chemotherapy-induced adverse reactions, and to summarize the mechanisms underlying the action.MethodsWe searched PubMed, Embase, ClinicalTrials.gov, and Web of Science from the start of the study to its completion on Dec. 31, 2021. Risk of bias was assessed using Cochrane Collaboration's Tool. Statistical analysis of the acquired data was performed via the RevMan and the Stata Statistical Software. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO registration number: CRD42020220650).ResultsTwelve randomized controlled trials including 1,013 patients were recruited and analyzed via the standard procedure of meta-analysis. In contrast to the control group, orally taking probiotics significantly decreased the risk of chemotherapy-induced diarrhea (≥ 1 grade) (RR = 0.70; 95% Cl: 0.56, 0.88; P = 0.002) and oral mucositis (≥ 1 grade) (RR: 0.84; 95% Cl: 0.78, 0.91; P < 0.00001) at all grades. Further analysis found that severe diarrhea (≥ 2 grades) (RR: 0.50; 95% Cl: 0.32, 0.78; P = 0.002) and severe oral mucositis also significantly declined (≥ 3 grades) (RR: 0.66; 95% Cl: 0.55, 0.79; P < 0.00001) after oral probiotic use. Interestingly, the beneficial effects of probiotics displayed statistically significant only in Asian patients. Importantly, the more species of bacteria they took, the lower the incidences of the adverse reactions occurred. We used Egger's test P value to confirm that there is no publication bias.ConclusionsThis meta-analysis demonstrated that orally administrated probiotics has a potential to decrease chemotherapy-induced diarrhea and oral mucositis incidences. However, the efficacy of oral probiotic use against the adverse reactions needs to be further verified through more clinical trials, and the species and number of probiotics have to be optimized and standardized prior to clinical applications.Systematic Review Registrationhttps://www.crd.york.ac.uk, identifier: 220650.

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“…Probiotics are generally considered safe and well-tolerated. They have been proven to be advantageous in battling various diseases, such as metabolic disorders, inflammatory bowel disease and colon cancer [ 136 , 137 , 138 ]. Many studies have shown that probiotics have a beneficial effect on serum zonulin levels, which constitute a measure of intestinal permeability.…”

Section: Zonulinmentioning

confidence: 99%

The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity

Serek

Oleksy-Wawrzyniak

2021

IJMS

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The intestinal barrier plays an extremely important role in maintaining the immune homeostasis of the gut and the entire body. It is made up of an intricate system of cells, mucus and intestinal microbiota. A complex system of proteins allows the selective permeability of elements that are safe and necessary for the proper nutrition of the body. Disturbances in the tightness of this barrier result in the penetration of toxins and other harmful antigens into the system. Such events lead to various digestive tract dysfunctions, systemic infections, food intolerances and autoimmune diseases. Pathogenic and probiotic bacteria, and the compounds they secrete, undoubtedly affect the properties of the intestinal barrier. The discovery of zonulin, a protein with tight junction regulatory activity in the epithelia, sheds new light on the understanding of the role of the gut barrier in promoting health, as well as the formation of diseases. Coincidentally, there is an increasing number of reports on treatment methods that target gut microbiota, which suggests that the prevention of gut-barrier defects may be a viable approach for improving the condition of COVID-19 patients. Various bacteria–intestinal barrier interactions are the subject of this review, aiming to show the current state of knowledge on this topic and its potential therapeutic applications.

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Sa1838 - The Clinical and Circulating Inflammatory Cytokines Effects of Probiotic Containing Lactobacillus and Bifidobacterium Strains in Patients with Colorectal Cancer: A Randomized Double Blind Controlled Trial

Cited by 6 publications

References 0 publications

Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential

Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential

Oral Administration of Probiotics Reduces Chemotherapy-Induced Diarrhea and Oral Mucositis: A Systematic Review and Meta-Analysis

The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity

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