Sa2012 Behavioral Despair Associated With a Mouse Model of Inflammatory Bowel Disease: Role of the Nitric Oxide Pathway

Heydarpour, Pouria; Rahimian, Reza; Fakhfouri, Gohar; Khoshkish, Shayan; Salehi-Sadaghiani, Mohammad; Fakhraei, Nahid; Abbasi, Ata; Heydarpour, F; Dehpour, Ahmad Reza; Ghia, Jean–Eric

doi:10.1016/s0016-5085(15)31286-5

Cited by 3 publications

(2 citation statements)

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“…In addition, elevated depressive symptoms over time were associated with increased odds of active IBD (155). Besides, in studies of induced colitis in mice, behavior abnormality consistent with depression was observed, accompanied with an increase in circulating pro-inflammatory cytokines (156,157). Interestingly, the anterior cingulate cortex (ACC), part of the autonomic forebrain loop, functioning as a relay hub and transmitting various input signals after evaluating requirements from other regions to guide adaptive behaviors, is particularly sensitive to cytokines (158, 159).…”

Section: Gut Inflammation and Depressionmentioning

confidence: 97%

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

Tan¹,

Yan

et al. 2022

Front. Neurol.

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Depression is a worldwide disease causing severe disability, morbidity, and mortality. Despite abundant studies, the precise mechanisms underlying the pathophysiology of depression remain elusive. Recently, cumulate research suggests that a disturbance of microbiota-gut-brain axis may play a vital role in the etiology of depression while correcting this disturbance could alleviate depression symptoms. The vagus nerve, linking brain and gut through its afferent and efferent branches, is a critical route in the bidirectional communication of this axis. Directly or indirectly, the vagus afferent fibers can sense and relay gut microbiota signals to the brain and induce brain disorders including depression. Also, brain changes in response to stress may result in gut hyperpermeability and inflammation mediating by the vagal efferents, which may be detrimental to depression. Notably, vagus nerve stimulation owns an anti-inflammatory effect and was proved for depression treatment. Nevertheless, depression was accompanied by a low vagal tone, which may derive from response to stress and contribute to pathogenesis of depression. In this review, we aim to explore the role of the vagus nerve in depression from the perspective of the microbiota-gut-brain axis, highlighting the relationship among the vagal tone, the gut hyperpermeability, inflammation, and depression.

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Section: Gut Inflammation and Depressionmentioning

confidence: 97%

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

Tan¹,

Yan

et al. 2022

Front. Neurol.

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“…Animal models of GIDD are associated with neuroinflammation, as evidenced by the induction of reactive phenotypes of glial cells, and increased expression of pro-inflammatory mediators in the CNS (Table 3). Increased neural expression of pro-inflammatory cytokines and enzymes and reactive glial phenotypes are reported in models of ulcerative colitis (243-249), Crohn's disease (250)(251)(252)(253), and IBS (254,255). Reports of reactive microglia and astrocytes are most commonly reported in the hippocampus.…”

Section: Animal Models Of Gidd Drive Neural Changesmentioning

confidence: 99%

Neuroinflammatory remodeling of the anterior cingulate cortex as a key driver of mood disorders in gastrointestinal disease and disorders

Matisz

Gruber

2022

Neuroscience & Biobehavioral Reviews

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Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

Matisz¹,

Gruber²

2020

Preprint

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The brain reciprocally communicates with the rest of the body via neural, endocrine, immune, and other systems. This is crucial for coordinating the complex behavioral and physiological responses needed to cope with the many challenges of life. The Anterior Cingulate Cortex (ACC) is a key brain structure involved in assessing rewards and threats, as well as activating appropriate responses. This is a dynamic process that depends on evolving needs and challenges. Important challenges include illness or injury. These typically involve inflammation and pain, which evoke neuroinflammatory processes in the brain to drive sickness behaviours. In the short term, sickness behaviours are considered adaptive, as they promote convalescence (e.g. low mood; lethargy, fatigue, social withdrawal), and enhanced threat appraisal (e.g. anxiety) to combat increased risk/vulnerability associated with sickness. Chronic inflammation, however, appears to remodel the system to inappropriately activate threat-coping responses, resulting in depressive and/or anxious phenotypes. These mood disorders are particularly pronounced in diseases and disorders associated with gut dysfunction, which feature chronic inflammation and altered ACC function. We propose that chronic inflammation remodels ACC physiology such that it errantly predicts heightened danger based on a mental model (a.k.a ‘schema’) of the world. This evokes chronic activation of threat-coping systems, including endocrine signaling (e.g. adrenaline), and anxiety. Inflammation can be driven by brain systems involving ACC, leading to a feedback-cycle that self-reinforces pathological states. This theory accounts for a wealth of clinical and preclinical data that implicate the ACC in disorders of mood and gastrointestinal function, and reveals a key player in the gut-brain axis that may represent a novel therapeutic target.

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Sa2012 Behavioral Despair Associated With a Mouse Model of Inflammatory Bowel Disease: Role of the Nitric Oxide Pathway

Cited by 3 publications

References 0 publications

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

Neuroinflammatory remodeling of the anterior cingulate cortex as a key driver of mood disorders in gastrointestinal disease and disorders

Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

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