Sa2016 - Fecal Microbiota Transplantation for Clostridium Difficile in Patients with Inflammatory Bowel Disease; the Pediatric Perspective

Nicholson, Maribeth R; Alexander, Erin; Ballal, Sonia A.; Bartlett, Mark; Becker, Penny; Davidovics, Zev; Doby, Elizabeth H.; Docktor, Michael; Dole, Michael; Felix, Grace; Gisser, Jonathan M.; Hourigan, Suchitra K.; Jensen, M. Kyle; Kaplan, Jess L.; Kelsen, Judith R.; Kennedy, Melissa; Khanna, Sahil; Leier, McKenzie; Lewis, Jeffery D.; Lodarek, Ashley; Michail, Sonia; Mitchell, Paul; Oliva‐Hemker, Maria; Patton, Tiffany; Queliza, Karen; Singh, Namita; Suskind, David L.; Solomon, Aliza; Werlin, Steven L.; Kellermayer, Richárd; Kahn, Stacy A.

doi:10.1016/s0016-5085(18)31752-9

Cited by 3 publications

(8 citation statements)

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“…In the pediatric population, a total of 6 studies30,32–35,37 included 141 patients who were treated with a single FMT with cure rates ranging from 46% to 100% among included studies. Of those, 106 patients had CDI resolution, with a pooled cure rate of 78% (95% CI: 58-93%; I 2 =59%) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen (13 adult and 3 pediatric) studies reported the risk of an IBD flare after FMT 8,14,18–24,28,29,32,35,37,38. Thirteen defined an IBD flare as escalation of therapy and/or worsening symptoms, but the definition of an IBD flare was not available in 3 studies (Supplementary Table 2, Supplemental Digital Content 2, http://links.lww.com/JCG/A792).…”

Section: Resultsmentioning

confidence: 99%

“…Seven adult studies 15,19,20,22,24,25,35 and three pediatric studies 32,33,36 analyzed a subjective improvement in IBD symptoms as an outcome after FMT. In adults, 78 of 231 patients had an improvement in IBD symptoms with a pooled rate of 33.8% (95% CI: 26.7%-42.1% I 2 = 64%).…”

Section: Ibd Symptom Improvementmentioning

confidence: 99%

“…Sixteen (13 adult and 3 pediatric) studies reported the risk of an IBD flare after FMT. 8,14,[18][19][20][21][22][23][24]28,29,32,35,37,38 Thirteen defined an IBD flare as escalation of therapy and/or worsening symptoms, but the definition of an IBD flare was not available in 3 studies (Supplementary Table 2, Supplemental Digital Content 2, http://links.lww.com/JCG/A792). In the adult population, a total of 141 of 527 patients experienced an IBD flare, with a pooled rate of 26.8% (95% CI: 22.5%-31.5% I 2 = 9%).…”

Section: Ibd Flare After Fmtmentioning

confidence: 99%

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Outcomes of Fecal Microbiota Transplantation for C. difficile Infection in Inflammatory Bowel Disease

Tariq

Syed

Yadav³

et al. 2021

Journal of Clinical Gastroenterology

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Background: Fecal microbiota transplantation (FMT) is a safe and effective therapy for recurrent Clostridioides difficile infection (CDI). Data on FMT for CDI in patients with underlying inflammatory bowel disease (IBD) are emerging but conflicting. We performed a systematic review and meta-analysis to describe the efficacy and safety of FMT for CDI in IBD and its impact on IBD outcomes. Methods: A systematic search of multiple databases including Embase, Scopus, and Web of Science was performed. Our primary analysis focused on pooled rate of CDI resolution after single and multiple FMTs in IBD patients. Additional analyses included rates of IBD-associated outcomes (flare, surgery, symptom improvement) after FMT. The random-effects model was used to calculate pooled rates. Results: Among 457 adult patients, 363 had CDI resolution after first FMT with a pooled cure rate of 78% [95% confidence interval (CI): 73%-83%; I 2=39%]. Overall pooled rate cure rate with single and multiple FMTs was 88% (95% CI: 81%-94%; I 2=73%). The pooled rate of an IBD flare after FMT was 26.8% (95% CI: 22.5%-31.6%; I 2=9%) and of colectomy was 7.3% (95% CI: 4.7%-10.5%; I 2=56%). Among 141 pediatric patients, 106 had CDI resolution after first FMT with pooled cure rate of 78% (95% CI: 58%-93%; I 2=59%). Overall pooled cure rate with single and multiple FMTs was 77% (95% CI: 50%-96%; I 2=63%). The pooled rate of an IBD flare after FMT was 10.8% (95% CI: 5.7%-18.5% I 2=43%), and of colectomy was 10.3% (95% CI: 2.1%-30.2% I 2=23%). Conclusions: FMT appears to be a highly effective therapy for preventing recurrent CDI in patients with IBD. Patients who fail a single FMT may benefit from multiple FMTs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Ibd Symptom Improvementmentioning

confidence: 99%

Section: Ibd Flare After Fmtmentioning

confidence: 99%

See 2 more Smart Citations

Outcomes of Fecal Microbiota Transplantation for C. difficile Infection in Inflammatory Bowel Disease

Tariq

Syed

Yadav³

et al. 2021

Journal of Clinical Gastroenterology

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“…Although the data regarding FMT among children are still limited and preliminary, FMT could be helpful in establishing a treatment alternative for recurrent CDI. A recent multi-center retrospective cohort study in the United States reported that FMT was successful in 272 of 336 (81%) children with CDI [61].…”

Section: Fecal Microbiota Transplantation (Fmt)mentioning

confidence: 99%

Development of the gut microbiota and dysbiosis in children

Akagawa

Yamanouchi

et al. 2021

Bioscience of Microbiota, Food and Health

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The gut microbiota resides in the human gastrointestinal tract, where it plays an important role in maintaining host health. Recent advancements in next-generation sequencing methods have revealed the link between dysbiosis (imbalance of the normal gut microbiota) and several diseases, as this imbalance can disrupt the symbiotic relationship between the host and associated microbes. Establishment of the gut microbiota starts in utero or just after birth, and its composition dramatically changes to an adult-like composition by 3 years of age. Because dysbiosis during childhood may persist through adulthood, it is crucial to acquire a balanced gut microbiota in childhood. Therefore, current studies have focused on the factors affecting the infant gut microbiota. This review discusses recent findings, including those from our studies, on how various factors, including the delivery mode, feeding type, and administration of drugs, including antibiotics, can influence the infant gut microbiota. Here, we also address future approaches for the prevention and restoration of dysbiosis in children.

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The gut microbiome and its use as a target for novel therapeutic modalities

Allam,

Al-Shaar

2023

Microbes and Infectious Diseases

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Background:The human microbiome is the complete microorganisms in addition to their genes inhabiting the human body. The gut microbiome is the most important part of the human microbiome. The gut microbiome serves many benefits to the host. It can ferment non digestible substrates, boost the immune system, suppress the growth of harmful microbiota, modulate gut development, metabolize xenobiotics, produce shortchain fatty acids, and produce favorable vitamins to the host. Gut dysbiosisis a factor in many disease states as obesity, various metabolic disorders, inflammatory bowel syndromes, cardiovascular diseases, and cancer. So novel therapies that can improve the human microbiome especially gut microbiome can be an addition to the conventional therapeutics. Novel therapeutics that improve the gut microbiome includes probiotics, prebiotics, synbiotics, psychobiotics and some metabolites. Other modalities that affect the microbiome were invented as faecal microbiota transplantation, phages, and emerging miRNAs. Fecal microbiota transplantation is now an approved method for management of patients of recurrent pseudomembranous colitis.

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Sa2016 - Fecal Microbiota Transplantation for Clostridium Difficile in Patients with Inflammatory Bowel Disease; the Pediatric Perspective

Cited by 3 publications

References 0 publications

Outcomes of Fecal Microbiota Transplantation for C. difficile Infection in Inflammatory Bowel Disease

Outcomes of Fecal Microbiota Transplantation for C. difficile Infection in Inflammatory Bowel Disease

Development of the gut microbiota and dysbiosis in children

The gut microbiome and its use as a target for novel therapeutic modalities

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