“…TTK plays a key role in safeguarding chromosome segregation fidelity, participating in the assembly of mitotic checkpoint complexes, regulating cytokinesis, responding to DNA damage, and promoting accurate chromosome alignment [ 9 ]. The spindle assembly checkpoint (SAC) represents the primary mechanism for preserving chromosomal stability during cytokinesis [ 10 ]. The SAC pathway, involving TTK, Polo, Aurora, Bub, BubR and Mad, detects misoriented chromosomes, establishes proper bipolar connections with the spindle, and diminishes chromosomal mismatch errors prior to late-stage initiation [ 8 ].…”