Saccades evoked in response to electrical stimulation of the posterior bank of the arcuate sulcus

Neromyliotis, Eleftherios; Moschovakis, Adonis

doi:10.1007/s00221-017-5012-6

Cited by 6 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is therefore not surprising that in addition to S-like saccade-related cells (Grantyn et al 2004;Moschovakis et al 1988;Sparks 1975;Wurtz and Goldberg 1972), the SC contains neurons activated for hand movements (Werner et al 1997a) as well as cells that, akin to Meq neurons, discharge for saccades and hand movements (Werner et al 1997b). The presence of robust saccaderelated signals in the caudal bank of the AS and the SC projections of this region led us to expect that its electrical stimulation would evoke saccades, a prediction that we were recently able to confirm (Neromyliotis and Moschovakis 2017a).…”

Section: Discussionmentioning

confidence: 83%

Response properties of saccade-related neurons of the post-arcuate premotor cortex

Neromyliotis

Moschovakis

2018

Journal of Neurophysiology

Self Cite

View full text Add to dashboard Cite

We studied the phasic saccade-related discharges of single neurons (S neurons) of the premotor cortex of female rhesus monkeys, mostly in the caudal bank of the arcuate sulcus. As described in previous work from our laboratory (Neromyliotis E, Moschovakis AK. Front Behav Neurosci 11: 1-21, 2017), some of these cells emitted phasic discharges for coordinated movements of the eyes and hand as well as for movements of either effector executed in isolation (motor equivalence, Meq). Other cells (S) did not emit phasic discharges for hand movements unaccompanied by saccades. In contrast to frontal eye field (FEF) neurons, but similar to forelimb-related neurons (H neurons) and Meq cells, the discharges of S cells did not display contralateral bias; their on-directions were as likely to be ipsiversive as contraversive. Because the onset of their discharge preceded that of FEF neurons, S cells are unlikely to convey to their targets corollary discharges of the FEF. We also encountered a small number of neurons that could function as logic gates: cells that discharged for saccades if they were not accompanied by hand movements, cells that discharged for saccades or movements of the hand but not for coordinated movements of both effectors, and cells that discharged only for coordinated movements of the eyes and the hand but not when one of the effectors moved unaccompanied by the other. Our findings are discussed in terms of sequences of decision processes stitching effector-specific motor plans onto effector-invariant movement primitives. NEW & NOTEWORTHY The premotor cortex, traditionally associated with skeletomotor control, is shown to contain cells that emit strong discharges time-linked to saccades but not for hand movements unaccompanied by saccades (S cells). Unlike frontal eye field (FEF) neurons, the S cells of the premotor cortex did not display contralateral bias, and because their presaccadic discharges preceded those of FEF neurons, they are unlikely to serve as conveyors of FEF efferent discharges.

show abstract

Section: Discussionmentioning

confidence: 83%

Response properties of saccade-related neurons of the post-arcuate premotor cortex

Neromyliotis

Moschovakis

2018

Journal of Neurophysiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Further, as the cryoloops were not insulated on their posterior aspect, it is likely that we inactivated the posterior bank of arcuate sulcus. While electrically stimulating these sites evokes saccades, such evoked saccades are often ipsilaterally-directed, and are much slower than saccades evoked from stimulating FEF sites ( Neromyliotis and Moschovakis, 2017 ). Additionally, ablation of the posterior bank of arcuate sulcus did not produce the oculomotor deficits we report in this study ( Rizzolatti et al, 1983 ).…”

Section: Discussionmentioning

confidence: 99%

Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency

Dash

Peel

Lomber

2018

eNeuro

View full text Add to dashboard Cite

A neural correlate for saccadic reaction times (SRTs) in the gap saccade task is the level of low-frequency activity in the intermediate layers of the superior colliculus (iSC) just before visual target onset: greater levels of such preparatory iSC low-frequency activity precede shorter SRTs. The frontal eye fields (FEFs) are one likely source of iSC preparatory activity, since FEF preparatory activity is also inversely related to SRT. To better understand the FEF’s role in saccade preparation, and the way in which such preparation relates to SRT, in two male rhesus monkeys, we compared iSC preparatory activity across unilateral reversible cryogenic inactivation of the FEF. FEF inactivation increased contralesional SRTs, and lowered ipsilesional iSC preparatory activity. FEF inactivation also reduced rostral iSC activity during the gap period. Importantly, the distributions of SRTs generated with or without FEF inactivation overlapped, enabling us to conduct a novel population-level analyses examining iSC preparatory activity just before generation of SRT-matched saccades. When matched for SRTs, we observed no change during FEF inactivation in the relationship between iSC preparatory activity and SRT-matched saccades across a range of SRTs, even for the occasional express saccade. Thus, while our results emphasize that the FEF has an overall excitatory influence on preparatory activity in the iSC, the communication between the iSC and downstream oculomotor brainstem is unaltered for SRT-matched saccades.

show abstract

Comparative anatomy of the macaque and the human frontal oculomotor domain

Borra

Luppino

2021

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Saccades evoked in response to electrical stimulation of the posterior bank of the arcuate sulcus

Cited by 6 publications

References 61 publications

Response properties of saccade-related neurons of the post-arcuate premotor cortex

Response properties of saccade-related neurons of the post-arcuate premotor cortex

Frontal Eye Field Inactivation Reduces Saccade Preparation in the Superior Colliculus but Does Not Alter How Preparatory Activity Relates to Saccades of a Given Latency

Comparative anatomy of the macaque and the human frontal oculomotor domain

Contact Info

Product

Resources

About