Saccharin: a green, economical and efficient catalyst for the one-pot, multi-component synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole

Solvent-free and One-pot Facile Synthesis of 12-aryl-tetrahydrobenzo[α]xanthene-11-one Derivatives Promoted by Manganese (IV) oxide as Efficient Catalyst

“…Also, nuclear magnetic resonance, 1 H NMR spectra were recorded on a Bruker DRX-400 Avance instruments with CdCl 3 as solvents (Figure 1). In this article, all reagents and solvents were purchased from Merck, Fluka and Acros chemical companies were used without further purification.…”

“…Multi-component reactions (MCRs) [1][2][3][4] play an important role in combinatorial chemistry with high atom economy due to their ability to synthesize biologically active heterocyclic compounds. Xanthene derivatives possess a variety of pharmaceutical and biological activities.…”

Artificial sugar saccharin and its derivatives: role as a catalyst

“…Lassagne et al evaluated the saccharin as a organocatalyst for synthesis of pyrido [2,3-b]pyrazines and quinoxalines through cyclocondensation of various 1,2-arylenediamines with different 1,2-multicomponent synthesis of substituted dihydro-2-oxypyrrole, 1H-pyrazolo [1,2-b]phthalazine-5,10-dione and 3,4-dihydropyrimidin-2-(1H)-one derivatives as shown in Schemes 3-5 respectively. 14 Saccharin has important benets such as non-toxic, ecofriendly, green, high efficiently, environmentally benign nature, high catalytic activity, and low cost.…”

Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine, a green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free conditions

“…In recent years, organic chemists have focused their attention towards green chemistry for the synthesis of heterocyclic compounds using multi-component domino reactions (MCRs) [1][2][3][4][5][6] due to a broad range of notable advantages, such as non-toxic substrate and environmental friendliness. Atom economy, reduction in by-products, number of steps in an organic synthesis, energy cost, produced waste, use of non-hazardous reagents in catalytic protocols are some of the most important goals of green chemistry.…”