Saccular cerebral aneurysms in young adults

Kamitani, Hiroshi; Masuzawa, Hideaki; Kanazawa, Itaru; Kubo, Tetsuo

doi:10.1016/s0090-3019(00)00265-2

Cited by 19 publications

(31 citation statements)

References 34 publications

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“…6,9,20) The reports on the sex dominance in young adults are variable. 5,7,11,14,21) A slight male dominance was noted (58.3%) in the present study. The overall incidence of aneurysms in the study cohort was higher in male patients, but female dominance is noted with higher age (Fig.…”

Section: Discussionsupporting

confidence: 50%

“…7,12,14) The young adults presenting with aneurysmal SAH accounted for 9.1% of total patients presenting to our institute in the last 17 years. Modern diagnostic and intervention techniques are leading to more patients within this age group being treated for aneurysmal SAH.…”

Section: Discussionmentioning

confidence: 99%

“…The present study replicates the notion that multiple aneurysms are more common in females, but contradicts the association of hypertension with aneurysm multiplicity. 7) One of the major contributing risk factors for aneurysm seeding in young adults is smoking. 3) In this study, 20.3% of the patients had a history of smoking, and of these, 65.2% of the patients with a smoking history demonstrated a good outcome.…”

Section: Discussionmentioning

confidence: 99%

“…5) The bifurcation of the cir- Aneurysmal SAH in Young Adults cle of Willis in the anterior circulation was the most common site in young adults, and with advancing age, ruptured aneurysms in the anterior circulation increased and those in the posterior circulation remained constant. 7) Additionally, sex variation has been demonstrated in aneurysm location. The ACA is the most common location in males and the ICA in females.…”

Section: Discussionmentioning

confidence: 99%

“…9) Studies discussing outcomes of aneurysmal SAH in young adults have demonstrated favorable outcomes in this subgroup of patients. 5,7,11,14,21) As these patients continue to improve after discharge, vigilant supportive and rehabilitation care should be emphasized to ensure the optimal recovery. The mortality rate in the present study was 3.7% (4 patients).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Prediction of Outcomes in Young Adults With Aneurysmal Subarachnoid Hemorrhage

Chotai

Moon

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Subarachnoid hemorrhage (SAH) is rare in young adults and little is known about aneurysms in this subgroup. The effect of clinical and prognostic factors on the outcome based on the Glasgow Outcome Scale (GOS) scores and the predictors of unfavorable outcomes were analyzed in young adults with aneurysmal SAH. A retrospective review of the clinical parameters, including age, sex, hypertension, smoking status, hyperlipidemia, location of the cerebral aneurysm, size of the aneurysm, multiplicity, perioperative complication such as hydrocephalus, vasospasm, and hematoma, and Hunt and Hess and Fisher grading on presentation, was conducted in 108 young adults (mean age 34.8 years) managed at our institute. The outcome was classified based on GOS grading into unfavorable (GOS scores 1-3) or favorable (GOS scores 4 or 5). The overall mortality rate was 3.7% (4/108 patients). Univariate regression analysis for the outcomes at discharge found that age at the time of presentation, male sex, size of aneurysm, multiple aneurysms, hyperlipidemia, and poor Hunt and Hess and Fischer grades were associated with unfavorable outcome. Multivariate regression analysis found independent effects of sex, multiple aneurysms, size of aneurysm, and Hunt and Hess grade on the outcome at discharge. Size of aneurysm, presence of multiple aneurysms, Hunt and Hess grade, and hypertension were the predictors of outcome at mean 2-year follow up based on multivariate exact regression analysis. The multimodal approach with aggressive medical management, early intervention, and surgical treatment might contribute to favorable long-term outcomes in patients with poor expected outcomes.

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