Infusing plastic waste to concrete and masonry structures is an increasingly common industry practice that has the potential to create an environment-friendly material that can improve some of the material’s properties, craft a novel means to repurpose plastic waste, and reduce the need for mining aggregates in the environment. This concept has been studied extensively in different forms of concrete, as shown by several studies; however, there is a dearth of studies focusing on the incorporation plastic waste in concrete hollow blocks (CHB). In this study, we aim to fill that gap by investigating on the effects of incorporating low-density polyethylene (LDPE), a commonly used plastic material, to CHB on its compressive strength and bulk density. Samples of varying percentages of LDPE replacement by volume (0, 10, 20, 30 and 40%) were fabricated and tested. Results showed a general trend of decreasing compressive strength and bulk density upon increasing the amount of LDPE pellets in CHB, which was also observed in previous studies. However, the compressive strength of CHB increased at 10% LDPE replacement, a result similar to a previous study. It was inferred that the strength of the plastic material could have a direct contribution to the compressive strength of CHB at low percentage of aggregate replacement. Statistical analysis showed that the mix with 10% LDPE pellets as replacement to sand was the best among the samples tested. It was shown that CHB infused with LDPE pellets has a higher compressive strength than what is normally used in the Philippines. It was concluded that based on compressive strength and bulk density, LDPE pellets is a viable material to use as partial replacement to sand in non-load bearing CHB.