Sacrococcygeal extradural ependymoma

Lemberger, Anshel; Stein, Moshe; Doron, Jaffa; Fried, Geta; Goldsher, Dorith; Feinsod, Moshé

doi:10.1002/1097-0142(19890901)64:5<1156::aid-cncr2820640532>3.0.co;2-y

Cited by 27 publications

(15 citation statements)

References 19 publications

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“…EEP der Sakralregion werden sowohl dorsal subkutan als auch ventral präsakral beschrieben [6]. Daneben gibt es EEP des Ovars sowie des Mediastinums.…”

Section: Diskussionunclassified

Sacrococcygeales extraspinales myxopapilläres Ependymom - Fallbericht

Tröbs¹,

Sorger²,

Schütz³

2006

Klin Padiatr

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A 9-year-old boy was admitted with a circumscript subcutaneous tumor of the sacral region. Serum alpha-fetoprotein was not elevated. The lesion was excised en bloc including the top of the coccygis. Histology revealed a myxopapillary ependymoma without bony involvement. Metastases were excluded. Extraspinal myxopapillary ependymoma is a rare tumor of the sacrococcygeal region with a potential risk to develop metastases and for local relapse. Long-term follow-up is recommended.

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“…EEP der Sakralregion werden sowohl dorsal subkutan als auch ventral präsakral beschrieben [6]. Daneben gibt es EEP des Ovars sowie des Mediastinums.…”

Section: Diskussionunclassified

Sacrococcygeales extraspinales myxopapilläres Ependymom - Fallbericht

Tröbs¹,

Sorger²,

Schütz³

2006

Klin Padiatr

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“…The surgical goal with all ependymomas, whether they are intra-or extradural, is gross-total resection when feasible. 16 Gross-total resection provides a possibility for cure without the definite need for adjuvant therapy. For intradural ependymomas in this location, gross-total resection is the most frequently cited factor influencing prognosis in terms of local recurrence and patient survival.…”

Section: Treatment Optionsmentioning

confidence: 99%

“…There appears to be a consensus for radiation therapy in cases of subtotal resections of intradural tumors, although the role for radiation in cases of gross-total resection and extradural ependymomas is controversial. 3,5,7,10,11,16,28,29,31,33,35 Sonneland, et al, 33 based on their large series of patients, recommended local radiation therapy in cases of subtotal or piecemeal gross-total resection. Nevertheless, in reviewing their data, there appears to be no trend toward improved survival or recurrence rates with radiation therapy.…”

Section: Treatment Optionsmentioning

confidence: 99%

“…Others hypothesize that these ependymal rests are heterotopias that occur as a result of incomplete closure of the neural arch. 12,16,17,20 Presacral ependymomas are thought to arise from ependymal cell rests or in association with cauda equina nerve roots that have exited the sacral neural foramen. Histologically, all reported cases of extradural ependymomas have been myxopapillary types.…”

mentioning

confidence: 99%

“…Histologically, all reported cases of extradural ependymomas have been myxopapillary types. 8,10,16,17,25,34 …”

mentioning

confidence: 99%

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Lumbosacral ependymomas: a review of the management of intradural and extradural tumors

Fassett¹,

Schmidt²

2003

FOC

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Object The goal of this study was to review the management of intra- and extradural ependymomas. Spinal ependymomas most commonly occur as intramedullary tumors throughout the spinal axis. In the lumbosacral region, ependymomas are most commonly associated with the conus medullaris and cauda equina, but can also occur extradurally in the sacrum, presacral tissues, or subcutaneous tissues over the sacrum. These two tumor locations produce different management concerns. Intradural ependymomas, especially those in the lumbosacral region, are now recognized for their potential to spread throughout the central nervous system (CNS), whereas extradural tumors elicit more concern for their association with extraneural metastases. Methods The authors have reviewed the literature regarding both of these distinct tumors and have summarized recommendations for the management of intra- and extradural lumbosacral ependymomas. For both tumors, it appears that gross-total resection is the treatment of choice when feasible. The role of radiation therapy has not been adequately studied for either tumor location, but most clinicians use this modality in patients with subtotal resection of intradural ependymomas, local recurrence, or CNS dissemination. Data supporting the use of radiation therapy for extradural ependymomas are lacking. There does not appear to be a significant role for chemotherapy in either tumor location. Conclusions Despite the risk for local recurrence and CNS dissemination, the prognosis for intradural lumbosacral ependymomas is good, with a greater than 90% 10-year patient survival in most series. The prognosis for extradural ependymomas does not appear to be as good. Much depends on extradural tumor location, however; the outlook is better for dorsal sacral tumors than presacral tumors.

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