Safe administration of yellow fever vaccine in patients with suspected egg allergy

Lopes., Fernanda Tormin Tanos; Romanelli, Roberta Maia de Castro; Oliveira, Lívia Isabela de; Abrantes, Marcelo Militão; Rocha, Wilson

doi:10.1016/j.jacig.2023.100089

Journal of Allergy and Clinical Immunology: Global

2023

DOI: 10.1016/j.jacig.2023.100089

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Safe administration of yellow fever vaccine in patients with suspected egg allergy

Fernanda Tormin Tanos Lopes.¹,

Roberta Maia de Castro Romanelli²,

Lívia Isabela de Oliveira³

et al.

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2024

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Cited by 2 publications

References 19 publications

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No Yellow Fever Vaccine Reactions in IgE-Mediated Egg Allergic Patients

Ramírez-Giraldo,

Giraldo-Avila,

Calle

et al. 2024

Int Arch Allergy Immunol

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Introduction: Egg allergy usually manifests during the initial 2 years of life, a period in which most vaccinations are administered. This often leads to delays in the application of some vaccines in patients with egg allergies, exposing them to a risk of contracting preventable infections. The aim of the study was to describe the frequency of reactions after applying the yellow fever vaccine (YFV) within a population with egg allergy. Methods: This was a cohort study with retrospective, multicenter data (2014–2023). Patient records diagnosed with egg allergy were gathered from their initial egg-related reactions until their YFV administration. Information was also collected about hypersensitivity tests conducted for egg and YFV such as the skin prick test (SPT) and intradermal test (IDT). Results: Among the 171 records analyzed, 23.9% of patients had a history of egg anaphylaxis. Out of these, 5 patients had a positive SPT and 21 IDT with the YFV. All patients tolerated the application of YFV without developing hypersensitivity reactions, regardless of the results of the YFV tests, the severity of egg reactions, the number of egg reactions, or the time since the last egg reaction. Out of the total patient cohort, 46.1% (79 individuals) encountered delays in receiving the YFV, and in this subset, 14% faced delays lasting longer than 12 months. Conclusion: The risk of allergic reactions with the YFV remains low. YFV tests generate delays in the vaccine application without providing high diagnostic accuracy. YFV should not be deferred even in patients with a history of severe egg reactions.

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No Yellow Fever Vaccine Reactions in IgE-Mediated Egg Allergic Patients

Ramírez-Giraldo,

Giraldo-Avila,

Calle

et al. 2024

Int Arch Allergy Immunol

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Rare causes of pediatric anaphylaxis due to obscure allergens

Melethil,

Yousef

2024

Front. Allergy

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This review provides a comprehensive overview of rare causes of pediatric anaphylaxis related to obscure allergens. Anaphylaxis, a severe hypersensitivity reaction, can occur without typical symptoms, posing diagnostic challenges, especially in children. Idiopathic anaphylaxis, where no trigger is identified despite thorough evaluation, is notably challenging in this population. This review synthesizes current literature, highlighting obscure triggers such as food additives, spices like fenugreek, and cross-reactive allergens, including lupine and gelatin. These allergens are often overlooked and can lead to misdiagnosis of idiopathic cases. Understanding these uncommon triggers is crucial for clinicians to ensure accurate diagnosis and effective management of pediatric anaphylaxis, emphasizing the need for heightened clinical awareness and further research. This review raises awareness among health care providers about these lesser-known causes, aiming to improve outcomes and quality of life for pediatric patients at risk of anaphylactic reactions.

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Safe administration of yellow fever vaccine in patients with suspected egg allergy

Cited by 2 publications

References 19 publications

No Yellow Fever Vaccine Reactions in IgE-Mediated Egg Allergic Patients

No Yellow Fever Vaccine Reactions in IgE-Mediated Egg Allergic Patients

Rare causes of pediatric anaphylaxis due to obscure allergens

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