Safe blood transfusion practices in blood banks of Karachi, Pakistan

Kassi, Mahwash; Afghan, Abdullah; Khanani, Rafiq; Khan, Ibrar; Ali, Syed

doi:10.1111/j.1365-3148.2010.01042.x

Cited by 12 publications

(14 citation statements)

References 11 publications

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“…Studies have highlighted the alarming situation in blood banks, whereby prospective donors may be neither screened not interviewed regarding high-risk behaviour. 4,9 There is currently no insight into the type of blood donation and HIV surveillance in private blood banks and the majority of public blood banks, 20-25% of which are dependent on paid professional donors. These are potentially injection drug users, among whom the reported HIV prevalence is about 20%.…”

Section: Discussionmentioning

confidence: 99%

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HIV prevalence in blood donors and recipients in Pakistan: a meta-analysis and analysis of blood-bank data

Moiz

Ali

Chatha

et al. 2015

WHO South-East Asia J Public Health

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Very few reports on HIV in blood donors in Pakistan could be retrieved, and the overall pooled prevalence is low. However, the limited data and confounding factors mean that that these results may significantly underestimate the true situation. It is recommended that a complete survey of blood banks should be conducted throughout the country, in order to provide a more reliable estimate of the risk of transfusion-associated HIV infection in Pakistan.

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Section: Discussionmentioning

confidence: 99%

“…8 An important step was promulgation of the Safe Blood Transfusion Act by provincial legislature in 1997, under which the Sindh Blood Transfusion Authority (SBTA) was formed. 9 SBTA enrolled 146 banks in the province of Sindh that met its standards, and closed down 126 substandard blood banks. 10 Similar initiatives were subsequently taken by other provinces.…”

mentioning

confidence: 99%

HIV prevalence in blood donors and recipients in Pakistan: a meta-analysis and analysis of blood-bank data

Moiz

Ali

Chatha

et al. 2015

WHO South-East Asia J Public Health

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“…In the recent past, however, the level of awareness and sensitization about blood safety and particularly the significance of voluntary donations and screening of donated blood has improved considerably. Paid donations are becoming uncommon and the predominant reliance is on the replacement donors [2]. The prevalences of Hepatitis B, C and HIV show wide variation in the general public and blood donors [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Trends in Transfusion Transmitted Infections Among Replacement Blood Donors in Karachi, Pakistan

Irfan

Uddin

Zaheer

et al. 2013

Tjh

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Objective: To determine the prevalence of Hepatitis-B, Hepatitis-C and Human Immunodeficiency infections in replacement blood donors.Materials and Methods: From January 2004 to December 2011, 108,598 apparently healthy donors donated blood at our Blood Bank. Screening was done by Microparticle Enzyme Immuno Assay (MEIA) method on Axsym System (Abbott Diagnostic, USA) and in year 2011 by Chemiluminescent Immunoassay (CIA) method on Architect i2000 (Abbott Diagnostic, USA). From 2010 onward, HIV reactive donors were advised for confirmatory tests and reported back with the results.Results: Of the 108,598 total donors, 108,393 (99.8%) were replacement donors with a mean age of 28.92 (17-55) years. Of this, only 164 (0.15%) were females. Among the replacement donors, 4,906 (4.5%) were found to be reactive for Hepatitis-B, C and Human Immunodeficiency Virus. All the reactive patients, except one, were males. HbsAg was positive in 2,068 (1.90%) and anti-HCV in 2832 (2.61%) donors, while 111 (0.10%) were positive for Human Immunodeficiency Virus. Co-infectivity was observed in 103 (0.09%) cases. The prevalence appeared to be higher in younger age group (17-30 yrs). Only 16.6% cases should be patients returned with results of the confirmatory tests for HIV and were found positive.Conclusion: Hepatitis-B and C sero-prevalence in our series of replacement donors appears high compared to most studies from neighboring countries and relatively low in comparison to earlier studies from Pakistan. Prevalence of HIV, however, appears low and turn out of HIV positive cases for confirmatory tests is low.Conflict of interest:None declared.

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“…However, there is a huge gap between supply and demand (7). Approximately 90% of donations are based on exchange donors; remaining are voluntary, non-remunerated.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Blood Utilization for Stem Cell Transplant Patients in a Tertiary Care Hospital

Ali

2017

IJSC

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Background and ObjectiveHaematopoietic stem cell transplant is a potentially curative treatment option in various benign and malignant haematological diseases. Patients undergoing stem cell transplant procedure require blood transfusion on a daily basis. Currently, there is paucity of data from developing countries on transfusion practices. This audit was undertaken to determine the consumption of packed red blood cells (PRBCs) transfusion in the bone marrow transplant unit of the Aga Khan University Hospital.Subjects and MethodsA retrospective audit was conducted for packed red cell transfusion ordering practice over a period from June 2014~June 2015. All consecutive patients, admitted for stem cell transplant procedure for various underlying diseases were included. Outcome measures used in this study were (i) cross match to transfusion (C: T) ratio and (ii) transfusion trigger.ResultsDuring the study period, n=25 patients underwent haematopoietic stem cell transplant. There were n=19 males and n=6 females. One patient was less than 15 years of age while rests were adults. Median age±SD was 26.5±14.5 years (12~54 years). The underlying diagnosis included Aplastic anemia (n=8), Thalassemia major (n=3), Multiple Myeloma (n=4), Acute leukemia (n=5), Hodgkin’s lymphoma (n=4), PRCA (n=1). Grand total consumption of PRBCs during the study period was 204 while 258 products were crossmatch. The C:T ratio was 1.26. The transfusion trigger was Hb level of less than 8 gms/dl.ConclusionThe results of our BMT unit indicate that the C:T ratio and transfusion trigger is comparable to the international benchmark.

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Safe blood transfusion practices in blood banks of Karachi, Pakistan

Abstract: SBT practices in Karachi have improved since 1995; an active role by the government in policy-making has proven effective.

Cited by 12 publications

References 11 publications

HIV prevalence in blood donors and recipients in Pakistan: a meta-analysis and analysis of blood-bank data

HIV prevalence in blood donors and recipients in Pakistan: a meta-analysis and analysis of blood-bank data

Trends in Transfusion Transmitted Infections Among Replacement Blood Donors in Karachi, Pakistan

An Analysis of Blood Utilization for Stem Cell Transplant Patients in a Tertiary Care Hospital

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