Safe Management of Chemotherapy: Infusion-Related Complications

Schulmeister, Lisa

doi:10.1188/14.cjon.283-287

Cited by 9 publications

(10 citation statements)

References 15 publications

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“…[5][6][7]13 However, glucocorticoids do not affect the primary mechanism of anthracycline tissue damage and are not currently recommended for management of anthracycline extravasation due to controversial outcomes. 3,15 In 2007 U.S. Food and Drug Administration (FDA) approved anthracycline antidote dexrazoxane for the treatment of anthracycline extravasation with a 3-day treatment schedule consisting of a daily intravenous infusion of 1000, 1000, and 500 mg/m2 of dexrazoxane over 1-2 hrs. Dexrazoxane prevents double-strand DNA breaks and reduces the formation of toxic anthracycline-iron complexes and its administration is recommended in current guidelines.…”

Section: Discussionmentioning

confidence: 99%

Delayed presentation of doxorubicin extravasation into pleural space: Case report and review of literature

Kazakova

Vanegas

Torres

et al. 2020

J Oncol Pharm Pract

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Introduction Intrathoracic extravasation of anthracyclines is a dangerous and very rare complication of chemotherapy administration. While management of extravasation into soft tissues has been established, the data on treatment of mediastinal and intrapleural anthracycline extravasation is limited. Case Report We present a case of a 52-year-old woman with intrapleural doxorubicin extravasation who presented to the hospital 24-hrs after chemotherapy infusion with chest pain and shortness of breath. Management & Outcome The patient underwent urgent surgical intervention and received IV dexrazoxane 36-hrs after the event. Her pain improved, but she continued to have chest soreness and pleural effusion at the site of extravasation even 3 months later. Discussion We conducted review of literature using Medline/PubMed and Google Scholar databases and identified 7 cases of intrapleural and mediastinal anthracycline extravasation. No data is currently available regarding the outcome of delayed management of intrapleural anthracycline extravasation with dexrazoxane. Prevention and confirmation of adequate port catheter placement is the most important step to avoid such cases. Catheter misplacement should be suspected in any patient presenting with post procedural chest pain and should trigger a thorough evaluation prior to any chemotherapy administration.

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Section: Discussionmentioning

confidence: 99%

Delayed presentation of doxorubicin extravasation into pleural space: Case report and review of literature

Kazakova

Vanegas

Torres

et al. 2020

J Oncol Pharm Pract

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“…DNA'ya bağlanmayan ajanlar; vinkaalkaloidleri, taksanlar ve trabektedin. Bu gruptaki ilaçlar hızlı metabolize olur, genellikle lokalizedir ve zamanla düzelir (17,18). DNA'ya bağlanan ajanlar; alkilliyeci ajanlar, antrasiklinler, anti-tümör antibiyotikler şeklinde sınıflandırılmaktadır.…”

Section: Vezikantlarunclassified

“…Ektravaze olduklarında nadir görülen akut reaksiyon sonucu lokalize doku hasarı gelişir ve zamanla düzelme görülür (12,18).…”

Section: Non-vezikantlarunclassified

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Kemoterapiye Bağlı Ekstravazasyon Yönetimi

Uçar¹,

Arıkan²

2018

Akd Med J

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Solid tümörlerin tedavisinde kullanılan intravenöz kemoterapi ilaçları sistemik yanıtın etkin ve hızlı olması nedeniyle yaygın olarak kullanılmaktadır. Kemoterapinin önemli komplikasyonlardan birisi ekstravazasyondur. Ekstravazasyon, ilacın infüzyonu sırasında subkutan ve subdermal alana infiltrasyonu sonucu gelişen doku hasarıdır. Yumuşak doku hasarından nekroz oluşumuna kadar farklı klinik tablolarda görülebilen kemoterapi ekstravazasyonu klinik uygulamalar açısından önemlidir. Bu derlemede ekstravazasyon, sınıflaması ve yönetimi gözden geçirilmiştir.

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“…This questionnaire was developed by the researchers in an English language based on the review of related literatures [26], [27] and, [28] to assess patients' knowledge regardingchemotherapy infusion instructions. It included 38 true& false questions grouped into six subgroups to assess patients' knowledge regarding the following: definition and importance of chemotherapy (3questions), preparation of patients (2questions), infusion session (6 questions), expected side effects(10 questions), danger signs(3 questions), and nursing role (14 questions).…”

Section: Interview Questionnaire Sheet: To Assess Patients 'Knowledgementioning

confidence: 99%

Patients' Satisfaction Level Regarding Chemotherapy Infusion Session for Breast Cancer

Talima

Abdel-Hakeim

Hamza

et al. 2018

IJND

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Background: Breast cancer is a major health problem in females worldwide. About 12% or one in eight woman's at risk to developbreast cancer during lifetime. Chemotherapy produces a harmful effect of patients' well-being. Patient satisfaction is avaluable aspect of healthcare organization and it is reflect on patients' outcomes. The aim of the study: to assess patients' satisfaction level regarding chemotherapy infusion session for breast cancer. Methods: A quasi-experimental research design was utilized in the current study. The study was conducted at center of radiation oncology and nuclear medicine outpatient clinic affiliated to Governments Cairo University Hospital, Egypt. Subjects: A purposive sample of one group of 174 adult breast cancer females undergoing first dose of chemotherapy. Tools of data collections: Four tools were used for data collection: 1) patients' demographic characteristics 2) Interview questionnaire sheet 3)OUT PATSAT35 satisfaction questionnaire, and4)A telephone follows up call script.Results: revealed that, there was a highly statistically significant improvement in total knowledge and satisfaction of patients' pre and post intervention (P>0.001).Conclusion: The current study concludes that, the implementation of the chemotherapy infusion instructions session had a statistically significant positive effect on improving patients' knowledge and satisfaction.Recommendation:The study recommended that, application of telephone follow up call in the oncology setting to assist patients to overcome ofchemotherapy side effect, give guidance and support, and increase patients' satisfaction.

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Safe Management of Chemotherapy: Infusion-Related Complications

Abstract: The following is a reprint from Chapter 8 in Chemotherapy and Biotherapy Guidelines and Recommendations for Practice (Fourth Edition) by Martha Polovich, PhD, RN, AOCN®, MiKaela Olsen, MS, RN, AOCNS®, and Kristine B. LeFebvre, MSN, RN, AOCN® (Eds.).

Cited by 9 publications

References 15 publications

Delayed presentation of doxorubicin extravasation into pleural space: Case report and review of literature

Delayed presentation of doxorubicin extravasation into pleural space: Case report and review of literature

Kemoterapiye Bağlı Ekstravazasyon Yönetimi

Patients' Satisfaction Level Regarding Chemotherapy Infusion Session for Breast Cancer

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