Safe perioperative tamoxifen use in autologous breast free flap reconstruction: systematic review and meta-analysis

Webster, Theresa K.; Roth, Stéphanie; Yu, Daohai; Baltodano, Pablo A.; Araya, Sthefano; Elmer, Nicholas; Kaplunov, Briana; Massada, Karen E; Talemal, Lindsay; Hackley, Madison; Patel, Sameer A.

doi:10.1007/s10549-022-06558-8

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Typically, this interruption in Tamoxifen treatment was deemed acceptable without significant risk of cancer progression or recurrence, although conclusive evidence is still lacking [61]. Webster et al have demonstrated that, compared to patients who did not receive Tamoxifen perioperatively, those who received Tamoxifen did not have an increased risk of thrombotic flap complications after an autologous breast free flap reconstruction surgery [62].…”

Section: Tamoxifenmentioning

confidence: 99%

Anti-cancer Therapies in Adults and Their Effects on Cardiovascular System: A Review

Habbal,

Ouarrak,

Dehbi

2024

Cardiol. Angiol. Int. J.

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The cardio-oncology as a field has been expanded by the rapid development of innovative cancer therapies. While these treatments had significantly improved the overall survival rates for cancer patients, they also carried the risk of cardiovascular and metabolic toxicities. A comprehensive and accurate diagnosis of cancer was paramount to initiate appropriate and effective treatment strategies. It was essential to recognize that each type of cancer presents unique characteristics and complexities, necessitating personalized treatment approaches tailored to individual patients. These treatment regimens often encompassed a combination of modalities such as surgery, radiotherapy, systemic therapy, including chemotherapy, antineoplastic hormonal agents, targeted therapies, and supportive care interventions. By implementing a tailored treatment plan based on the specific nature of the cancer, healthcare professionals might optimize therapeutic outcomes while minimizing adverse effects, ultimately improving the overall prognosis and quality of life for cancer patients. The concise review aims to underscore the effects of cancer and its treatments on cardiovascular health, drawing insights from prior research. By synthesizing findings from existing studies, we aim to elucidate the intricate relationship between cancer therapies and cardiovascular outcomes. Consequently, there is a pressing need for an updated summary to inform contemporary clinical practice, ensuring that healthcare professionals are equipped with the latest knowledge to provide optimal care for cancer patients while safeguarding their cardiovascular well-being.

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Section: Tamoxifenmentioning

confidence: 99%

Anti-cancer Therapies in Adults and Their Effects on Cardiovascular System: A Review

Habbal,

Ouarrak,

Dehbi

2024

Cardiol. Angiol. Int. J.

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“…The pathogenesis of seroma formation is not completely clear; however, several factors have been reported as probable causes. These factors include age (Lembo et al, 2021), hypertension (Hwang et al, 2021), elevated body mass index (Caputo et al, 2021), number of malignant nodules (da Costa Vieira et al, 2021), and the use of electrosurgery (Sforza et al, 2017; Watkins et al, 2008; Webster et al, 2022).…”

mentioning

confidence: 99%

Using Drain-Free Flap Fixation Techniques Versus Traditional Wound Closure With Drain Placement to Prevent Seroma Formation and Its Complications in Breast Cancer Patients Undergoing Mastectomy: A Systematic Review and Meta-analysis

Soltani

Kargar

Jafari-Nedooshan

et al. 2022

Plastic and Aesthetic Nursing

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During the past decade, there has been some controversy related to using flap fixation techniques instead of conventional wound closure methods and drain placement during mastectomy procedures. The purpose of our study was to address this controversy using a systematic review and meta-analysis of current published literature. Nineteen studies met our inclusion criteria. Our sample population consisted of 2,956 participants divided into two groups. The study group (SG) consisted of 1,418 individuals and the control group (CG) consisted of 1,538 participants. We found there was a significant reduction in the incidence of seroma formation (odds ratio [OR] = 0.35; 95% confidence interval, CI [0.3, 0.42]; p < .000) and surgical site infection (OR = 0.65; 95% CI [0.48, 0.88]; p = .006) in the SG compared with the CG. The length of hospital stay was also significantly reduced in the SG (0.59 days; 95% CI [0.73, 0.46]; χ2[6, N = 502] = 52.88; p < .000) compared with the CG. The results of our study show that using a flap fixation technique after mastectomy can decrease the patient's risk for seroma formation and surgical site infection while reducing their length of hospital stay. Further studies with longer follow-up periods are warranted to evaluate long-term complications associated with using a flap fixation technique compared with using conventional wound closure techniques and drain placement.

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A UK consensus statement on thromboprophylaxis for autologous breast reconstruction

Savage

Hunt

Stansby

et al. 2023

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Safe perioperative tamoxifen use in autologous breast free flap reconstruction: systematic review and meta-analysis

Cited by 3 publications

References 20 publications

Anti-cancer Therapies in Adults and Their Effects on Cardiovascular System: A Review

Anti-cancer Therapies in Adults and Their Effects on Cardiovascular System: A Review

Using Drain-Free Flap Fixation Techniques Versus Traditional Wound Closure With Drain Placement to Prevent Seroma Formation and Its Complications in Breast Cancer Patients Undergoing Mastectomy: A Systematic Review and Meta-analysis

A UK consensus statement on thromboprophylaxis for autologous breast reconstruction

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