Safe(r) by design implementation in the nanotechnology industry

Jiménez, Araceli Sánchez; Puelles, Raquel C.; Pérez-Fernández, Marta; Gómez-Fernández, Paloma; Barruetabeña, Leire; Jacobsen, Nicklas Raun; Suárez-Merino, Blanca; Micheletti, Christian; Manier, Nicolas; Trouiller, Bénédicte; Navas, José M.; Kálmán, Judit; Salieri, Beatrice; Hischier, Roland; Handzhiyski, Yordan; Apostolova, Margarita D.; Hadrup, Niels; Bouillard, Jacques; Oudart, Yohan; Merino, C.; Garcia, Erika; Liguori, Biase; Sabella, Stefania; Rose, Jérôme; Armand, Michel; Galea, Karen S.; Kelly, Sean; Štěpánková, Sandra; Mouneyrac, Catherine; Barrick, Andrew; Châtel, Amélie; Dušinská, Maria; Rundén-Pran, Elise; Mariussen, Espen; Bressot, Christophe; Aguerre-Chariol, Olivier; Shandilya, Neeraj; Goede, Henk; Gómez, Julio; Simar, Sophie; Nesslany, Fabrice; Jensen, Keld Alstrup; Tongeren, Martie van; Llopis, Isabel Rodríguez

doi:10.1016/j.impact.2020.100267

Cited by 29 publications

(22 citation statements)

References 15 publications

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“…Compared to the older approach, which focused on measures applied retroactively, this approach would ideally be employed in the first steps of development, rather than once the process is started. However, improvements in reducing the risk for humans and the environment can still be achieved even in the later stages [28][29][30].…”

Section: Methodsmentioning

confidence: 99%

“…As an example, in a company that used pure silicon nanoparticles to increase the performance of batteries, the SbD concept implementation helped in lowering the toxicity threat for the workers, as well as lowering the risk of explosion, while achieving higher stability and performance. To do so, the nanoparticles' size was increased from 40 nm to 75 nm to reduce the alveolar deposition and the nanoparticles were coated with amorphous carbon, which led to increased performance and lower risk of explosion [29,31].…”

Section: Methodsmentioning

confidence: 99%

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Sustainable Coatings on Metallic Alloys as a Nowadays Challenge

2021

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Starting with a description of the meaning of sustainable coating nowadays, this review presents a selection of methods for sustainable coatings manufacture using raw materials, saving energy and costs. This selection creates an introduction for the coatings performances of intensively investigated coated alloys and their multifunctionality. There are many examples and EU recommendations to be discussed, and we especially chose to introduce sustainable coatings with both industrial and medical functions, such as bioinspired films and coatings on high-entropy alloys, biodegradable metallic alloys, etc. A special focus is on nanotechnology and nanomaterials in green procedures, enhancing coatings’ multifunctionality, introducing green corrosion inhibitors, smart additives, and coatings based on superhydrophobicity. The conclusions and future perspectives of sustainable and multifunctional coatings, as expressions of sustainable advanced materials, are based on important motivations of such studies.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Sustainable Coatings on Metallic Alloys as a Nowadays Challenge

2021

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“…The progression from one stage to the next is regulated by a gate, where the project is evaluated according to a set of adaptable safety criteria, leading to a decision on whether to continue the project or not. Case studies for applying the SbD approach have been performed by the nanotechnology industry ( Sánchez Jiménez et al, 2020 ).…”

Section: Shifting From Safe-by-design To Safe- and Sustainable-by-designmentioning

confidence: 99%

Safe- and sustainable-by-design: The case of Smart Nanomaterials. A perspective based on a European workshop

Mech

Gottardo

Amenta

et al. 2022

Regulatory Toxicology and Pharmacology

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The European Commission's Green Deal is a major policy initiative aiming to achieve a climate-neutral, zero-pollution, sustainable, circular and inclusive economy, driving both the New Industrial Strategy for Europe and the Chemicals Strategy for Sustainability. Innovative materials can help to reach these policy goals, but they need to be safe and sustainable themselves. Thus, one aim is to shift the development of chemicals to Safe- and Sustainable-by-Design, and define a new systems approach and criteria for sustainability to achieve this. An online workshop was organised in September 2020 by the Joint Research Centre and the Directorate-General Research and Innovation of the European Commission, with participants from academia, non-governmental organisations, industry and regulatory bodies. The aims were to introduce the concept of Safe- and Sustainable-by-Design, to identify industrial and regulatory challenges in achieving safer and more sustainable Smart Nanomaterials as an example of innovative materials, and to deliver recommendations for directions and actions necessary to meet these challenges. The following needs were identified: (i) an agreed terminology, (ii) a common understanding of the principles of Safe- and Sustainable-by-Design, iii) criteria, assessment tools and incentives to achieve a transition from Safe-by-Design to Safe- and Sustainable-by-Design, and (iv) preparedness of regulators and legislation for innovative chemicals/nanomaterials. This paper presents the authors' view on the state of the art as well as the needs for future activities, based on discussions at the workshop and further considerations. The case of Smart Nanomaterials is used to illustrate the Safe- and Sustainable-by-Design concept and challenges for its implementation. Most of the considerations can be extended to other advanced materials and to chemicals and products in general.

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“…Common areas to consider in creating a wholistic framework applicable to the rapid pace of nanotechnology development and to the ensuing regulatory requirements include knowledge sharing and transparency in nanotechnology research and development [ 28 • ], stakeholder awareness and participation [ 29 ], acknowledgement of the pacing problem [ 30 ], implementation of sustainability impact assessments [ 31 ], and bioavailability [ 32 ]. Some systems, such as Quality by Design (QbD) [ 19 • ] and the OECD’s Safe(r) Innovation Approach for implementing safety-by-design [ 33 ] in nanotechnology applications have been outlined but have yet to be implemented.…”

Section: Moving Forward: Operationalizing Resiliencementioning

confidence: 99%