Safe use of oral cytotoxic medicines

Carrington, Christine

doi:10.18773/austprescr.2013.006

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…The drug information center of the hospital standardized prescription information which are matched many standard and guidelines. [5,10,13] The prescriptions in RICK hospital are hand written and it was attached with patient file when coming at the pharmacy for dispensing. May studies [3,4,17] reported that the using of the hand written prescription was commonly prevalent, while the using of electronic system prescription was highly encouraged and stated in many guidelines [11,12] which may reduce errors.…”

Section: Discussionmentioning

confidence: 99%

“…methotrexat (MTX) with Nonsteroidal Anti-infammatory drugs NSAID or aspirin). ASCO guideline [13] and Carrington C [10] stated that reviewing the current medications should be performed with the patient to identify potential medication interactions or interference with dietary intake.…”

Section: Discussionmentioning

confidence: 99%

“…Which creates challenges and increase responsibilities for healthcare professionals in patient education. [5,6,10] Safe practicing of oral cytotoxic drugs involves the processes of prescribing, dispensing, patient education, administration, handling and storage of these drugs. [11] This study concentrates on the implementation of safety practices guidelines of these drugs among pharmacies staff.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Pharmacist Dispensing Practices and their Educational Role Toward Patients on Oral Cytotoxic Drugs Regimen in Radiation and Isotopes Center at Khartoum, Sudan

Mohamed¹,

Mousnad²

2020

JPPCM

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Background: Increasing use of oral cytotoxic chemotherapy among cancer patient in Sudan, rising important concern about safety practicing and using of these drugs. This study aimed to assess and demonstrate pharmacist dispensing pattern and their educational role toward patients on oral cytotoxic drugs regimen in Radiation and Isotopes Center at Khartoum (RICK). Methods: Across-sectional study was carried out at (RICK) hospital pharmacies. Data collected by using self-administered questionnaire distributed to all staff in active works (40 pharmacists) during February 2016. Results: All the participants responded to the questionnaire. The study reported variation among pharmacists when checking prescription. In which 97.4% of them checked drug name while only 76.9% calculating the dose according to the body surface area. For the patients-pharmacist counseling and it is effectiveness the study revealed that 77.5% of pharmacist providing counseling for the patient at the first visit. 75% of pharmacists counseling the drugs regimen. 28.1% of them including the drugs side effects and management. The counseling of the drugs handling and storage was registered by 65.6% of the participants. 53.1% of the pharmacists advice the patients to swallow the tablets and not crush it. The drugs interaction was counseled by 9.4% and only 2% of pharmacists counseled patients about medications teratogenicity. The finding revealed significant association between pharmacist experience and counseling practice by chi-square (p-value=0.008) while, the hospital training and staff attending has on significant association with (p-value=0.922, p-value=0.479). Conclusion: The study concluded that dispensing practice among pharmacists was main divers. Moreover, most of the pharmacists followed no standard when counseling patients and their experience becomes the main source when educating them.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of Pharmacist Dispensing Practices and their Educational Role Toward Patients on Oral Cytotoxic Drugs Regimen in Radiation and Isotopes Center at Khartoum, Sudan

Mohamed¹,

Mousnad²

2020

JPPCM

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“…4 The complex and intermittent nature of many OAM protocols, combined with the narrow therapeutic window of OAMs has led to serious toxicities and fatal outcomes when errors in prescribing, dispensing and patient interpretation of dosing instructions have occurred. 5 Despite carrying the same risks for errors and toxicities as anticancer medication administered by other routes, 4,6 OAMs are often not subject to the same rigorous prescribing, checking, dispensing, education and monitoring procedures. 7 Self-administration of OAMs may also lead to both under-and overadherence by patients, which may adversely affect their treatment outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…However, the autonomous self‐administration of oral anticancer therapy may lead to reduced detection of drug, dose or scheduling errors . The complex and intermittent nature of many OAM protocols, combined with the narrow therapeutic window of OAMs has led to serious toxicities and fatal outcomes when errors in prescribing, dispensing and patient interpretation of dosing instructions have occurred . Despite carrying the same risks for errors and toxicities as anticancer medication administered by other routes, OAMs are often not subject to the same rigorous prescribing, checking, dispensing, education and monitoring procedures .…”

Section: Introductionmentioning

confidence: 99%

Implementation and evaluation of a pharmacist‐led oral anticancer medication management clinic

Byrne

Redmayne

Lam

et al. 2018

Pharmacy Practice and Res

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Background Oral anticancer medication (OAM) use is increasing in prevalence. Although OAM offers many advantages to patients, there is also a high risk of medication errors. Aim This study aimed to evaluate whether a pharmacist‐led OAM management clinic would improve patient understanding and adherence to OAMs and reduce medication errors. Methods Patients commencing OAM in the Oncology Outpatient Clinic between July 2015 and April 2016 were eligible for the study. OAM understanding was evaluated using a patient survey before and after initial pharmacist review, in the middle of the first cycle and prior to the second cycle. Education and symptom management advice were provided, as well as referral if required. Pharmacist interventions were documented, then independently assigned a significance rating by a medical officer and pharmacist. Local community pharmacists were approached to complete a survey investigating their practices and confidence dispensing OAMs. Results In all, 29 patients participated in the clinic. Survey results before and after initial pharmacist review showed a trend towards improved patient understanding, which was maintained mid‐cycle and before the second cycle. In addition, 51 pharmacist interventions were recorded: one of high, 32 of moderate and 18 of minimal clinical significance. Self‐reported adherence mid‐cycle and before the second cycle found that 1/18 and 1/9 patients, respectively, forgot to take a dose of their OAM and that 3/18 and 1/9 patients, respectively, reported not taking a dose for other reasons. The community pharmacist survey revealed that 40 and 50% were confident educating patients about OAM dosage regimens and side effects, respectively. Conclusion Although the significance of the pharmacists’ education and interventions cannot be determined because of the small sample size, a valuable service was implemented to meet patient needs and expectations.

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Improvements in Clinical Trials Information Will Improve the Reproductive Health and Fertility of Cancer Patients

Dauti

Gerstl

Chong

et al. 2017

Journal of Adolescent and Young Adult Oncology

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There are a number of barriers that result in cancer patients not being referred for oncofertility care, which include knowledge about reproductive risks of antineoplastic agents. Without this information, clinicians do not always make recommendations for oncofertility care. The objective of this study was to describe the level of reproductive information and recommendations that clinicians have available in clinical trial protocols regarding oncofertility management and follow-up, and the information that patients may receive in clinical trials patient information sheets or consent forms. A literature review of the 71 antineoplastic drugs included in the 68 clinical trial protocols showed that 68% of the antineoplastic drugs had gonadotoxic animal data, 32% had gonadotoxic human data, 83% had teratogenic animal data, and 32% had teratogenic human data. When the clinical trial protocols were reviewed, only 22% of the protocols reported the teratogenic risks and 32% of the protocols reported the gonadotoxic risk. Only 56% of phase 3 protocols had gonadotoxic information and 13% of phase 3 protocols had teratogenic information. Nine percent of the protocols provided fertility preservation recommendations and 4% provided reproductive information in the follow-up and survivorship period. Twenty-six percent had a section in the clinical trials protocol, which identified oncofertility information easily. When gonadotoxic and teratogenic effects of treatment were known, they were not consistently included in the clinical trial protocols and the lack of data for new drugs was not reported. Very few protocols gave recommendations for oncofertility management and follow-up following the completion of cancer treatment. The research team proposes a number of recommendations that should be required for clinicians and pharmaceutical companies developing new trials.

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Safe use of oral cytotoxic medicines

Cited by 5 publications

References 7 publications

Assessment of Pharmacist Dispensing Practices and their Educational Role Toward Patients on Oral Cytotoxic Drugs Regimen in Radiation and Isotopes Center at Khartoum, Sudan

Assessment of Pharmacist Dispensing Practices and their Educational Role Toward Patients on Oral Cytotoxic Drugs Regimen in Radiation and Isotopes Center at Khartoum, Sudan

Implementation and evaluation of a pharmacist‐led oral anticancer medication management clinic

Improvements in Clinical Trials Information Will Improve the Reproductive Health and Fertility of Cancer Patients

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