Safer alternatives? Bisphenol F and Bisphenol S induce oxidative stress in Drosophila melanogaster larvae and trigger developmental damage

Musachio, Elize Aparecida Santos; Poetini, Márcia Rósula; Janner, Dieniffer Espinosa; Fernandes, Eliana Jardim; Meichtry, Luana Barreto; Dahleh, Mustafa Munir Mustafa; Guerra, Gustavo Petri; Prigol, Marina

doi:10.1016/j.fct.2023.113701

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…VitE and BPS metabolism are very similar in humans and animals [ 117 ]. The metabolism of BPS is generally performed by liver cytochrome P450 and CYP3A4 enzymes [ 118 , 119 , 120 , 121 ]; in addition, VitE is metabolized as a xenobiotic by the cytochrome P450 and increases the expression of cytochrome P-450-3A [ 104 , 122 ]; its metabolism uses liver-binding proteins, which selectively bind α-tocopherol. The α-tocopherol transfer protein mediates its transport from the liver to lipoproteins to maintain homeostatic control of α-tocopherol concentrations in blood and tissues [ 117 , 123 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats

Peña-Corona,

Vargas-Estrada,

Chávez-Corona

et al. 2023

Toxics

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This study investigated whether the coadministration of vitamin E (VitE) diminishes the harmful effects provoked by plasticizer bisphenol S (BPS) in the serum metabolites related to hepatic and renal metabolism, as well as the endocrine pancreatic function in diabetic male Wistar rats. Rats were divided into five groups (n = 5–6); the first group was healthy rats (Ctrl group). The other four groups were diabetic rats induced with 45 mg/kg bw of streptozotocin: Ctrl-D (diabetic control); VitE-D (100 mg/kg bw/d of VitE); BPS-D (100 mg/kg bw/d of BPS); The animals from the VitE + BPS-D group were administered 100 mg/kg bw/d of VitE + 100 mg/kg bw/d of BPS. All compounds were administered orally for 30 days. Body weight, biochemical assays, urinalysis, glucose tolerance test, pancreas histopathology, proximate chemical analysis in feces, and the activity of antioxidants in rat serum were assessed. The coadministration of VitE + BPS produced weight losses, increases in 14 serum analytes, and degeneration in the pancreas. Therefore, the VitE + BPS coadministration did not have a protective effect versus the harmful impact of BPS or the diabetic metabolic state; on the contrary, it partially aggravated the damage produced by the BPS. VitE is likely to have an additive effect on the toxicity of BPS.

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Section: Discussionmentioning

confidence: 99%

Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats

Peña-Corona,

Vargas-Estrada,

Chávez-Corona

et al. 2023

Toxics

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“…The detoxifying enzyme glutathione S-transferase (GST) was determined following the method described by Santos Musachio et al [ 25 ]. In this analysis, GST catalyzes the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione (GSH), producing the thioether 4-dinitrophenyl glutathione.…”

Section: Methodsmentioning

confidence: 99%

The Amazonian Camu-Camu Fruit Modulates the Development of Drosophila melanogaster and the Neural Function of Adult Flies under Oxidative Stress Conditions

Musachio,

Pires,

Fernandes

et al. 2024

Antioxidants

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Camu-camu (Myrciaria dubia) is known for its antioxidant properties, although little is known about its developmental safety effects, particularly on adult neural function under basal redox and oxidative stress conditions. Therefore, this study sought to address this gap by conducting three complementary protocols using Drosophila melanogaster to investigate these effects. The initial assays revealed that second-stage larvae consumed diets supplemented with various concentrations of camu-camu uniformly, establishing a 50% lethal concentration at 4.799 mg/mL. Hence, non-lethal (0.1, 0.5, and 1 mg/mL) and sub-lethal (5 and 10 mg/mL) concentrations were then chosen to evaluate the effects of camu-camu on preimaginal development and adult neural function. Our observations showed that camu-camu impacts the expression of antioxidant enzymes, reactive species, and lipoperoxidation. Notably, sub-lethal concentrations decreased preimaginal viability and locomotor activity, negatively influenced geotaxis and acetylcholinesterase activity, and increased reactive species, catalase, and glutathione S-transferase activity in flies. Additionally, the protective effects of camu-camu against oxidative stress induced by iron (20 mM) were assessed. Flies supplemented with 0.5 mg/mL of camu-camu during the larval period showed improved neural viability and function, and this supplementation was found to protect against oxidative stress. These findings are instrumental in evaluating the safety and efficacy of commercial supplements based on camu-camu, offering significant insights for future research and application.

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Oxidative damage analysis and cell viability of Drosophila melanogaster exposed to three different endodontic sealers: an in vivo and ex vivo study

Malta,

Musachio,

Fernandes

et al. 2024

Odontology

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Safer alternatives? Bisphenol F and Bisphenol S induce oxidative stress in Drosophila melanogaster larvae and trigger developmental damage

Cited by 4 publications

References 33 publications

Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats

Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats

The Amazonian Camu-Camu Fruit Modulates the Development of Drosophila melanogaster and the Neural Function of Adult Flies under Oxidative Stress Conditions

Oxidative damage analysis and cell viability of Drosophila melanogaster exposed to three different endodontic sealers: an in vivo and ex vivo study

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