2012
DOI: 10.1371/journal.pone.0033103
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Safety and Adherence to Intermittent Pre-Exposure Prophylaxis (PrEP) for HIV-1 in African Men Who Have Sex with Men and Female Sex Workers

Abstract: BackgroundLittle is known about safety of and adherence to intermittent HIV PrEP regimens, which may be more feasible than daily dosing in some settings. We present safety and adherence data from the first trial of an intermittent PrEP regimen among Kenyan men who have sex with men (MSM) and female sex workers (FSW).Methods/Principal FindingsMSM and FSW were randomized to daily oral FTC/TDF or placebo, or intermittent (Monday, Friday and within 2 hours after sex, not to exceed one dose per day) oral FTC/TDF or… Show more

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Cited by 132 publications
(171 citation statements)
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“…Although several studies are emerging with regard to the acceptability of oral PrEP in different populations, [14][15][16][17][18] to our knowledge, this is the first to assess the acceptability of oral versus rectal PrEP among MSM and TGW who mainly practice URAI. Importantly, data for this study were collected in 2008, before the results of the iPrEx study were disseminated in 2010, 2 thereby providing a unique opportunity to assess the potential PrEP acceptability when the approach was still hypothetical.…”
Section: Discussionmentioning
confidence: 99%
“…Although several studies are emerging with regard to the acceptability of oral PrEP in different populations, [14][15][16][17][18] to our knowledge, this is the first to assess the acceptability of oral versus rectal PrEP among MSM and TGW who mainly practice URAI. Importantly, data for this study were collected in 2008, before the results of the iPrEx study were disseminated in 2010, 2 thereby providing a unique opportunity to assess the potential PrEP acceptability when the approach was still hypothetical.…”
Section: Discussionmentioning
confidence: 99%
“…A study in Kenya also found out that adherence to intermittent dosing regimens, particularly coitally dependent doses, may result in poorer adherence than with daily dosing. It also reported high acceptability of PrEP, regardless of dosing regimen, indicating potential to roll out PrEP among MSM in Africa (Mutua, Sanders, Mugo, Anzala, Haberer, Bangsberg, et al 2012).…”
Section: Studies On Strategic Use Of Anti-retroviral Therapy Among Msmentioning
confidence: 98%
“…Adherence was low in some sites outside the United States (U.S.), raising many questions about applicability to diverse populations, the critical importance of adherence counseling and monitoring, optimal dosing intervals, and method of delivery. 10 Whereas different studies among MSM and TGW are either planned or in progress to assess these questions, [11][12][13][14][15][16] other studies are trying to translate positive PrEP findings into programmatic priorities to address the need to identify and implement innovative evidence-based HIV prevention strategies. [17][18][19][20][21][22][23][24][25][26] In addition to advocacy from populations at risk and governmental support of public health rollout programs, two critical aspects of a successful prevention program include a high-risk population willing to use such a method and providers willing to prescribe and monitor it.…”
Section: Introductionmentioning
confidence: 99%