Safety and anti-hyperglycemic efficacy of various tea types in mice

Han, Manman; Zhao, Guangshan; Wang, Yijun; Wang, Dongxu; Sun, Feng; Ning, Jingming; Wan, Xiaochun

doi:10.1038/srep31703

Cited by 51 publications

(34 citation statements)

References 51 publications

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“…Ortsäter et al [ 21 ] reported that, in db/db mice, EGCG reduced the pathological changes of islets and increased the number and size of islet cells, thus accordingly improving the function of pancreatic secretion, which helped to delay the course of metabolic syndrome. However, it has been proven that high doses of EGCG produced cytotoxicity and hepatotoxicity, which indicates that crude extracts might be safer than a single substance [ 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Large yellow tea, made from “one bud 6 leaves” of tea plant ( Camellia sinensis) , is one of the most famous traditional yellow teas in China, which is very popular because of its unique burnt flavor. A recent study from the Institute of Cancer Research (ICR) proved that yellow tea had a significant anti-hyperglycemic effect in high-fat-diet-induced mice when compared with green tea, black tea, and dark tea, which confirmed that yellow tea had a certain role in the recovery of glucose metabolism disorder [ 22 ]. However, high-fat-diet-induced ICR mice are not typical diabetic mice, and there is a lack of long-term experiments investigating the effect of yellow tea on rodent models of metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Supplement of Large Yellow Tea Ameliorates Metabolic Syndrome and Attenuates Hepatic Steatosis in db/db Mice

Teng

Guruvaiah

et al. 2018

Nutrients

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Yellow tea has been widely recognized for its health benefits. However, its effects and mechanism are largely unknown. The current study investigated the mechanism of dietary supplements of large yellow tea and its effects on metabolic syndrome and the hepatic steatosis in male db/db mice. Our data showed that dietary supplements of large yellow tea and water extract significantly reduced water intake and food consumption, lowered the serum total and low-density lipoprotein cholesterol and triglyceride levels, and significantly reduced blood glucose level and increased glucose tolerance in db/db mice when compared to untreated db/db mice. In addition, the dietary supplement of large yellow tea prevented the fatty liver formation and restored the normal hepatic structure of db/db mice. Furthermore, the dietary supplement of large yellow tea obviously reduced the lipid synthesis related to gene fatty acid synthase, the sterol regulatory element-binding transcription factor 1 and acetyl-CoA carboxylase α, as well as fatty acid synthase and sterol response element-binding protein 1 expression, while the lipid catabolic genes were not altered in the liver of db/db mice. This study substantiated that the dietary supplement of large yellow tea has potential as a food additive for ameliorating type 2 diabetes-associated symptoms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary Supplement of Large Yellow Tea Ameliorates Metabolic Syndrome and Attenuates Hepatic Steatosis in db/db Mice

Teng

Guruvaiah

et al. 2018

Nutrients

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“…Li et al declared that TPS treatment could alleviate insulin resistance and decrease blood glucose in diabetic mice, which might be mediated by the regulation of the PI3K/Akt signal pathway as revealed by the up-regulated expression of PI3Kp85/p-Akt/GLUT4-signaling molecules [147]. Additionally, various kinds of tea might have different anti-hyperglycemic strength, and yellow tea might be a better choice compared to green and black teas [148]. In another study, mixtures of dried green tea leaves and Aquilariae lignum powder at weight ratio of 49:1 were wet-fermented for 12 h at 60 • C and steamed for 30 s at 100 • C after being dried for 1 week at 15 • C, then the steamed mixtures were cooled and additionally dried at 15 • C for 3 days [149].…”

Section: Anti-diabetic Effect In Vivomentioning

confidence: 99%

“…Consumption of tea has been reported with few adverse events [127,148,236]. Tumorigenic, mutagenic, teratogenic, and sub-chronic toxicity of tea-related ingredients have not been observed in animal experiments and human studies, and the no-observed-adverse-effect level (NOAEL), observed safety level, and tolerable upper intake level were far from the functional doses [26,222,223,237].…”

Section: Potential Safety Issuesmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

270

150

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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“…Tea is a worldwide consumed beverage and the green one is broadly used as a functional beverage and dietary antioxidant supplement as it contains more catechins, a potent antioxidant than the other type of Camellia sinensis tea (Tsai et al 2013). In addition, tea has demonstrated anti-hyperglycemic properties (in animal models) but its efficacies are associated with high-dose levels (Han et al 2016). Polyphenols are known to contribute to the dietary antioxidant upon consumption of fruits, herbs, and spices, which can be found in the tonic formulation and tea.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

Zayapor¹,

Abdullah²,

Mustapha³

2020

JSM

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Contemporary Malay health tonics labeled as botanical drinks are advertised in the Malaysian market as effective therapeutic supplements toward improving consumer health. The therapeutic claims associated with high antioxidants are based on the herbal ingredients used, yet unproven by scientific evidence. Moreover, they are mostly sweetened with sugar, which may arise the potential of diabetic risk. Thus, a dire clarification on the potential antioxidant status and diabetic risk of these products is essential to nullify over claims. Eight commercial botanical drinks that serve as health tonics were selected based on their advertisement popularity and traditional medicine sellers' interview feedbacks. The selected tonics were mutually compared with a green tea (DGT01) as the benchmark for their total phenolic content (TPC); antioxidant activities [the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging inhibition capacities, IC 50 ; Ferric ion reducing antioxidant power (FRAP); and Oxygen radical absorbance capacity (ORAC)], anti-diabetic property through the α-glucosidase inhibition (AGI) and as well as the sugar content. The results were mapped for variations using Principal Component Analysis (PCA). Three out of 8 health tonics (NS12, SK53, and MU13) has approximately 3 to 4-fold, 1.1-fold and 2.5-fold higher in TPC, ORAC, and FRAP reducing capacities, respectively. Only NS12 and SK53 showed strong AGI (>80% inhibition). Three tonics, NS12, SK53, and HS06 exhibited precaution levels of sugar with more than 180 mg of total sugars per serving. From the PCA, DGT01 was dissociated from any tonic. NS12 and SK23 were closely related in terms of antioxidant and AGI activities. Although they showed promising therapeutic benefits due to high antioxidant activities and low diabetic risk, the tonics' efficacies and safety are still dubious shall be verified by reliable clinical trials. The selection of a health tonic shall not only be based on multi antioxidant-rich ingredients but low in sugar for a healthier choice.

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Safety and anti-hyperglycemic efficacy of various tea types in mice

Cited by 51 publications

References 51 publications

Dietary Supplement of Large Yellow Tea Ameliorates Metabolic Syndrome and Attenuates Hepatic Steatosis in db/db Mice

Dietary Supplement of Large Yellow Tea Ameliorates Metabolic Syndrome and Attenuates Hepatic Steatosis in db/db Mice

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

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