Safety and Considerations of the COVID-19 Vaccine Massive Deployment

Li, Junwei; Song, Mingyue; Guo, Deyin; Yi, Yongxiang

doi:10.1007/s12250-021-00408-5

Cited by 4 publications

(5 citation statements)

References 40 publications

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“…Vaccine hesitation refers to the refusal or delay of vaccination due to the public's lack of awareness of a vaccine's safety, effectiveness, and disease prevention, as well as the influence of factors such as religion, politics, and the law ( 19 , 20 ). Previous studies showed that the main factors affecting vaccine hesitation included confidence in the safety and effectiveness of the vaccine, insufficient awareness of the hazards of diseases, doubts about the necessity of vaccination, vaccine availability, vaccine price acceptance, and availability of vaccination services ( 5 , 21 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

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Attitudes to Being Vaccinated Against COVID-19: A Survey of People With Epilepsy in China

et al. 2021

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Objective: We conducted a survey to assess vaccination coverage, vaccination willingness, and variables associated with vaccination hesitancy to provide evidence on coronavirus disease (COVID-19) vaccination strategies.Methods: This anonymous questionnaire study conducted a multicenter, cross-sectional survey of outpatients and inpatients with epilepsy (PWE) registered in epilepsy clinics, in 2021, in 10 hospitals in seven cities of Shandong Province.Results: A total of 600 questionnaires were distributed, and 557 valid questionnaires were returned. A total of 130 people were vaccinated against COVID-19. Among 427 unvaccinated participants, 69.32% (296/427) were willing to receive the COVID-19 vaccine in the future, and the remaining 30.68% (131/427) were unwilling to receive vaccination. Most (89.9%) of the participants believed that the role of vaccination was crucial in response to the spread of COVID-19. A significant association was found between willingness to receive the COVID-19 vaccine and the following variables: age, marital status, level of education, occupation, residence, seizure type, and seizure control after antiepileptic drug therapy. It is noteworthy that education level, living in urban areas, and seizure freedom were significantly related to willingness to receive COVID-19 vaccination.Conclusions: Vaccination is a key measure for the prevention and control of COVID-19, and most PWE are willing to be vaccinated. Vaccine safety, effectiveness, and accessibility are essential in combatting vaccine hesitation and increasing vaccination rates.

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Section: Discussionmentioning

confidence: 99%

“…Vaccination seems to be an effective way to solve this problem ( 3 ). A reasonable vaccination strategy has important social significance ( 4 , 5 ). To help control the COVID-19 pandemic, unprecedented efforts have been made to develop vaccines against this disease.…”

Section: Introductionmentioning

confidence: 99%

Attitudes to Being Vaccinated Against COVID-19: A Survey of People With Epilepsy in China

et al. 2021

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“…However, work on a universal influenza vaccine based on mRNA technology has just begun. Furthermore, as a new biotechnology, many regulations will be demanded and its accompanied uncertain safety and vaccine hesitancy need to be resolved [ 61 , 62 ]. However, promoted by the success of the SARS-CoV-2 mRNA vaccines, the advent of mRNA technology has made it possible to see the dawn of a universal influenza vaccine, despite that there are still many technical difficulties to be overcome, whether it is a multivalent mRNA vaccine using the exhaustive existing HA antigens or a multivalent mRNA vaccine based on the same conserved antigen combined with other conserved antigens; for example, the formulation of LNP formulations for encapsulated multivalent mRNA vaccines or the structure optimization of multivalent antigen fusion proteins, the development of more efficient delivery vectors, and the addition of novel adjuvants [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Advances in Nucleic Acid Universal Influenza Vaccines

Xu,

Ren,

Wang

et al. 2024

Vaccines

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Currently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus in spite of some drawbacks with them. However, due to the rapid evolution of influenza viruses, including seasonal influenza viruses and emerging zoonotic influenza viruses, there is an urgent need to develop broad-spectrum influenza vaccines to cope with the evolution of influenza viruses. Nucleic acid vaccines might meet the requirements well. Nucleic acid vaccines are classified into DNA vaccines and RNA vaccines. Both types induced potent cellular and humoral immune responses, showing great promise for the development of universal influenza vaccines. In this review, the current status of an influenza universal nucleic acid vaccine was summarized.

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“…Over 300 million confirmed cases of COVID-19 worldwide and over 5.5 million deaths in January 2022 [2]. Vaccination is one of the most effective strategies to reduce illness and mortality rates from the Covid-19 virus [3]. Various COVID-19 vaccines have been developed and used to fight against the pandemic [4].…”

Section: Introductionmentioning

confidence: 99%

“…Various COVID-19 vaccines have been developed and used to fight against the pandemic [4]. However, as a developing country, Thailand faces significant challenges in acquiring and distributing adequate vaccine supplies [3]. The majority of Thai people could only access the first Covid-19 vaccine, which was inactivated COVID-19 from China, called CoronaVac ® (Sinovac), in mid-2021 [5].…”

Section: Introductionmentioning

confidence: 99%

The humoral and cellular immune response of a third dose adenoviral-based vectored vaccine after a single or 2 shots of inactivated COVID-19 vaccine in healthy adults

Suparak

Bumroongthai

Jantapalaboon

et al. 2022

Preprint

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The coronavirus pandemic is a severe infectious respiratory disease which caused massive loss worldwide. Thailand was affected by the wild-type, and the Delta variant started in mid-2021. Due to the shortage of effective vaccines, the ministry of public health of Thailand suggested the heterologous vaccine scheme, which comprises inactivated COVID-19 vaccine (CoronaVac) and an adenoviral-based vectored vaccine (ChAdOx1). However, data on the humoral and cellular immune responses of the single or 2 shots of inactivated vaccine followed by the adenoviral-based vaccine are very limited. In this current study, the sera from participants who received either single or 2 shots of CoronaVac followed by the ChAdOx1 vaccine were evaluated for SARS-CoV-2 spike receptor-binding-domain (RBD) IgG. The cytokine level was also assessed using Luminex immunoassay. The PBMC were collected to evaluate spike-specific T-cell and B-cell responses. Participants who received 2 shots of CoronaVac followed by ChAdOx1 possessed significantly (P<0.0001) higher levels of spike RBD-specific IgG. They also exhibited a higher level of CD4+T-cell and IFN-gamma than those who received only 1 shot of CoronaVac followed by the ChAdOx1 vaccine. The volunteers who received two shots of CoronaVac followed by ChAdOx1 had a significantly (p<0.01) higher marginal B-cell response against wild-type SARS-CoV-2 S peptides than those who received only one shot of CoronaVac followed by ChAdOx1. Surprisingly, the class switch B-cell response to Delta variant SARS-CoV-2 S peptides of the volunteers who received 1 shot of CoronaVac followed by ChAdOx1 was significantly (p<0.01) higher than those who received 2 shots of CoronaVac. However, participants who received only a single shot of inactivated vaccine followed by an adenoviral-based vectored vaccine possessed a higher level of TNF-alpha and IL-6. This study indicated that boosting the ChAdOx1 as a third dose after completing 2 shots of CoronaVac induced strong humoral and cellular immune responses.

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Safety and Considerations of the COVID-19 Vaccine Massive Deployment

Cited by 4 publications

References 40 publications

Attitudes to Being Vaccinated Against COVID-19: A Survey of People With Epilepsy in China

Attitudes to Being Vaccinated Against COVID-19: A Survey of People With Epilepsy in China

Advances in Nucleic Acid Universal Influenza Vaccines

The humoral and cellular immune response of a third dose adenoviral-based vectored vaccine after a single or 2 shots of inactivated COVID-19 vaccine in healthy adults

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