Safety and effectiveness of 5‐aminolevulinic acid photodynamic therapy combined with fractional micro‐plasma radio‐frequency treatment for verrucous epidermal nevus: A retrospective study with long‐term follow‐up

Abstract

Epidermal nevi (EN) are proliferative epithelial diseases initially described by Von Baerensprung in 1863. The incidence rate is 1-3‰, and there is no preference for sex or race. 1 Although the etiology and pathogenesis are not completely clear, it has been reported that mutations in KRAS, PIK3CA, and FGFR3 genes are related to EN. 2,3 Verrucous epidermal nevus (VEN), also known as keratinocytic epidermal nevus (KEN), is one type of EN. The typical manifestation of VEN is yellow to tan verrucous papules or plaques with different sizes, shapes, and distributions. VEN usually occurs in infancy or early childhood, aggravating with increasing age. Lesions distribute on any part of the body, including the face, limbs, and trunk.Depending on the distribution, VEN is classified as localized VEN, systematized VEN, nevus unius lateralis, inflammatory linear verrucous epidermal nevus, and ichthyosis hystrix. 4

Microplasma radio frequency technology using stationary tips on pig skin: A histological study

“…Due to the dual benefits of RF and plasma, it can further enhance the therapeutic thermal effect, promote collagen regeneration and restructuring, and skin regeneration and repair. The MPRF is currently employed in clinical combination therapy (including CO 2 laser, 3 electron beam irradiation, 4 and photodynamic therapy 5 ) for the enhancement of hypertrophic scars. Some believe that plasma forms a non‐evaporative microablation on the skin surface while maintaining the epidermis as a natural dressing to promote skin healing and repair, and that exfoliation eventually lasts several days 6 .…”