2022
DOI: 10.3389/fphar.2022.887020
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Safety and effectiveness of fondaparinux as a postpartum thromboprophylaxis during puerperium among muslim women: A single centre prospective study

Abstract: Background: Venous thromboembolism (VTE) remains one of the leading causes of maternal morbidity and mortality, with postpartum period carrying the greatest risk. Perinatal thromboprophylaxis is often administered based on risk-factor assessment. Low molecular weight heparin has a proven safety profile in the obstetrics population, however, its porcine-derived content may lead to reduced uptake amongst certain religious groups. We aimed to evaluate the safety of fondaparinux as an alternative postpartum thromb… Show more

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“…The risk for VTE is highest during the postpartum period. At present, almost all guidelines discriminated between low- and high-risk women, and low-molecular-weight heparin (LMWH) is considered to be the preferred anticoagulant for both prophylaxis and treatment of VTE during pregnancy since it does not cross the placenta and is associated with a lower rate of bleeding complications than that of the unfractionated heparin [ 20 22 ]. However, the best strategy to assess and prevent postpartum VTE has not been determined so far [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…The risk for VTE is highest during the postpartum period. At present, almost all guidelines discriminated between low- and high-risk women, and low-molecular-weight heparin (LMWH) is considered to be the preferred anticoagulant for both prophylaxis and treatment of VTE during pregnancy since it does not cross the placenta and is associated with a lower rate of bleeding complications than that of the unfractionated heparin [ 20 22 ]. However, the best strategy to assess and prevent postpartum VTE has not been determined so far [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 99%