2021
DOI: 10.20996/1819-6446-2021-10-06
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Safety and Effectiveness of Pharmacologic Conversion of Atrial Fibrillation and Flutter: Results of Multicenter Trial. Part II: Assessment of Safety

Abstract: Aim. We aimed to assess safety and effectiveness of class III antiarrhythmic drug Refralon for conversion of atrial fibrillation (AFib) and flutter (AFl) in post-registration trial and to compare data of primary center (National medical research center in cardiology) with data of other hospitals.Material and Methods. We performed retrospective cohort study in 727 patients (451 enrolled in primary center and 276 enrolled in other hospitals) admitted between June 24, 2014 and June 24, 2019. Refralon was administ… Show more

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Cited by 7 publications
(1 citation statement)
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“…When used in doses up to 30 µg/kg, cavutilide demonstrates high antiarrhythmic action (up to 91.6%) in restoring sinus rhythm in patients with persistent AF/AFL, with a moderate risk of proarrhythmic effects (up to 1.7%) [11][12][13].…”
Section: Introductionmentioning
confidence: 99%
“…When used in doses up to 30 µg/kg, cavutilide demonstrates high antiarrhythmic action (up to 91.6%) in restoring sinus rhythm in patients with persistent AF/AFL, with a moderate risk of proarrhythmic effects (up to 1.7%) [11][12][13].…”
Section: Introductionmentioning
confidence: 99%