Safety and Efficacy of a Recombinant Hepatitis E Vaccine

Abstract

In a high-risk population, the rHEV vaccine was effective in the prevention of hepatitis E. (ClinicalTrials.gov number, NCT00287469 [ClinicalTrials.gov].).

Hepatitis E: Epidemiology and Natural History

“…92,93 These will be reviewed in a future issue of the Journal. Currently only one of these vaccines has been licensed and that too only in China.…”

Immunomodulatory effects of recombinant BCG expressing MSP-1C ofPlasmodium falciparumon LPS- or LPS+IFN-γ-stimulated J774A.1 cells

“…10,13,19,20 However, overproduction of inflammatory cytokines and NO leads to malarial anemia. [20][21][22] Development of recombinant DNA using live vectors from viruses 23,24 and bacteria [25][26][27][28] to deliver foreign antigens to the immune system has become a popular technique nowadays for developing new generation vaccines. Mycobacterium bovis bacille Calmette-Guérin (BCG), the only vaccine currently available for the prevention of tuberculosis, is among the most extensively used vector for developing recombinant vaccines for other diseases, including malaria.…”

Hepatitis-E-Virus

“…Ein weiterer Impfstoff, ein 56 kDa großes, im Baculovirussystem in Insektenzellen exprimiertes Fragment des ORF2, wurde in Nepal in Zusammenarbeit mit amerikanischen Partnern an Angehörigen des Militärs getestet; er erwies sich ebenfalls als immunogen und führte bei Geimpften zu einem hohen Schutz vor einer Infektion mit dem in Nepal prävalen-ten HEV-1 [213]. Weitere experimentelle Impfstoffe, die auf rekombinanten HEVProteinen bzw.…”