Safety and efficacy of a classical swine fever subunit vaccine in pregnant sows and their offspring

Lipowski, A.; Drexler, Christa; Pejsak, Z.

doi:10.1016/s0378-1135(00)00266-2

Cited by 28 publications

(16 citation statements)

References 7 publications

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“…These results could be explained by the fact that the subunit vaccine is based on E2 antigen only and it should be considered a killed type [20]. It is well known that inactivated vaccines do not interfere with MDA and thus have no negative infl uence on the development of active immunity [14]. Therefore, as shown in the presented study, piglets with different MDA status, could be effectively immunized with a subunit vaccine.…”

Section: Discussionmentioning

confidence: 75%

“…From the day when 28 piglets from A, B, C groups and D-control subgroup were experimentally infected, blood samples were obtained from the jugular vein of each individual piglet according to the following sampling scheme: 0, 2, 4,6,8,10,12,14,16,18,20,22,24,26, 28 days post infection (dpi) to detect the presence of antibodies against CSF, viremia and viral RNA (ELISA test and RT-PCR). The control of CSFV shedding by vaccinated, artifi cially infected piglets was performed by RT-PCR analysis of oropharyngeal and rectal swabs with the following sampling scheme: 0, 2, 4, 6, 8 and 10 dpi.…”

Section: Sample Collection -Blood Sera and Tissue Samplesmentioning

confidence: 99%

“…To overcome this problem, effective and safe subunit E2 marker vaccines with accompanying diagnostic tests are developed [6,7]. Two subunit vaccines based on baculovirus expression of the CSFV E2 glycoprotein have been registered [13,14]. The glycoprotein E2 exposed on the outer surface of the virus is the most immunogenic among all CSFV proteins, inducing production of neutralizing antibodies and protection against lethal challenge [2,4].…”

Section: Introductionmentioning

confidence: 99%

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Classical Swine Fever: Active Immunisation of Piglets with Subunit (E2) Vaccine in the Presence of Different Levels of Colostral Immunity (China Strain)

et al. 2014

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The aim of this study was to investigate the effi cacy of the subunit vaccine against virulent CSF infection in piglets deriving from sows vaccinated with China strain. The experimental research included 34 piglets aged 45 days (13 naïve and 21 piglets originating from sows immunized with China strain CSFV). Three experimental groups consisting of seven animals each were formed based on serological examination of piglets aged 40 days. At the age of 45 days, the piglets were vaccinated with a subunit vaccine. After revaccination, the piglets were challenged with a virulent CSFV strain. With the aim of controlling virus shedding, two susceptible piglets were introduced into each group. After challenge, clinical monitoring of animals was performed, and blood samples were obtained to detect viremia and the presence of antibodies against CSF. The control of CSFV shedding by vaccinated, artifi cially infected piglets was performed by RT-PCR analysis of oropharyngeal and rectal swabs. After death or sacrifi ce of the animals, autopsy was performed along with the gross pathological examination and tissue sampling with the purpose of determining the presence and distribution of CSFV (ELISA and RT-PCR). Application of the subunit vaccine in piglets originating from sows vaccinated with China-strain resulted in a good active immune response. Following challenge virus shedding was confi rmed, but without contact infection in susceptible animals in cohabitation. The results indicate that the subunit vaccine may have a potential application in the control of CSF in enzootic regions.

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Section: Discussionmentioning

confidence: 75%

Section: Sample Collection -Blood Sera and Tissue Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Classical Swine Fever: Active Immunisation of Piglets with Subunit (E2) Vaccine in the Presence of Different Levels of Colostral Immunity (China Strain)

et al. 2014

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“…Vakcinacija subjediničnom vakcinom indukuje sintezu antitela protiv E2 najranije 10 dpv (83), većinom 28 dpv (21) i kod svih 14 dpv 2 (55). Revakcinacijom se postiže skok titra antitela koja perzistiraju mesecima ali kod pojedinih jedinki nisu detektabilna 13 meseci kasnije (15).…”

Section: Imunološki Odgovor Nakon Vakcinacije Subjediničnom Vakcinomunclassified

“…Utvrđene razlike se mogu objasniti različitom prirodom subjedinične (inaktivisana) i vakcine sa K-sojem virusa KKS (atenuisana) (55). Slična eksperimentalna ispitivanja efikasnosti subjedinične vakcine kod zalučene prasadi poreklom od krmača vakcinisanih atenuisanom vakcinom su vršena na Tajlandu.…”

Section: Rezultati Patomorfološkog Pregleda Eksperimentalne Prasadiunclassified

Influence of colostral antibodes on immunity of piglets vaccinated against classical swine fiver

Radulović¹

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2009

EFSA Journal

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BACKGROUND AS PROVIDED BY THE COMMISSION Classical swine fever (CSF) is one of the diseases that has caused major socioeconomic damages in the EU during the last decades. Although during the last years considerable progress has been made in the eradication and prevention of the disease, the threat for an epidemic still exists. The main reasons are that CSF virus is still present in feral pigs of some Member States (MSs) and that the virus is endemic in the Balkan region, including the MSs Bulgaria and Romania. Control measures are in place for those areas within the EU but this situation remains a constant threat for new outbreaks in the domestic pig population.

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Safety and efficacy of a classical swine fever subunit vaccine in pregnant sows and their offspring

Cited by 28 publications

References 7 publications

Classical Swine Fever: Active Immunisation of Piglets with Subunit (E2) Vaccine in the Presence of Different Levels of Colostral Immunity (China Strain)

Classical Swine Fever: Active Immunisation of Piglets with Subunit (E2) Vaccine in the Presence of Different Levels of Colostral Immunity (China Strain)

Influence of colostral antibodes on immunity of piglets vaccinated against classical swine fiver

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