Safety and efficacy of a 5-minute infusion versus the standard 30-minute infusion for antibiotics in an outpatient setting

Abstract

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Pushing the agenda for intravenous push administration in outpatient parenteral antimicrobial therapy

“…Over a median treatment duration of 21 days and a combined 4326 doses given to 184 patients, the study found no rapid infusion-related adverse reactions and concluded that IVP for OPAT is clinically safe and well tolerated. 39 Another retrospective cohort study conducted within a health system evaluated the incidence of adverse events with IVP beta-lactams during the aforementioned 2017 national shortage of smallvolume parenteral solutions. In adult patients who received a 5-min slow IVP of aztreonam, ceftriaxone, cefepime, or meropenem, a total of 10 adverse events were identified among 1000 patients (1%).…”

“…Over a median treatment duration of 21 days and a combined 4326 doses given to 184 patients, the study found no rapid infusion-related adverse reactions and concluded that IVP for OPAT is clinically safe and well tolerated. 39 …”

Two bis-ligand-coordinated Zn(ii)-MOFs for luminescent sensing of ions, antibiotics and pesticides in aqueous solutions

“…4,5 Antibiotics are vital drugs that are effective against and prevent bacterial infection. 6,7 To date, hundreds of antibiotics have been commercialized and applied in human disease treatment, aquaculture and husbandry. [8][9][10] Antibiotics are excessively abused in and discharged from livestock and poultry, and superuous residuals overow from aquaculture production.…”