Safety and Efficacy of Antipsychotics in Pregnancy and Lactation

Odhejo, Yassar Islamail; Jafri, Afshan; Mekala, Hema Madhuri; Hassan, Mudasar; Khan, Ali Mahmood; Dar, Sabrina K; Ahmed, Rizwan

doi:10.4172/2329-6488.1000267

Cited by 6 publications

(8 citation statements)

References 46 publications

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“…In 2020, a study in Finland assessed 20 years of pregnancy (1996–2016) to compare 1,181,090 pregnancies [ 67 ]. Women were separated into three groups: exposed to FGA ( n = 1576), exposed to SGs ( n = 4115), and no antipsychotic exposure ( n = 22,125).…”

Section: Clinical Studiesmentioning

confidence: 99%

“…When compared to the unexposed group, SGAs were noted to have an increased risk of maternal diabetes (OR 1.43; 95% CI 1.25–1.65), rates of cesarean section (OR 1.35; 95% CI 1.18–1.53), and preterm birth (OR 1.29; 95% CI 1.03–1.62). Additionally, the study reported an increase in infants being born large for gestational age (LGA) when compared to both unexposed (OR 1.57; 95% CI 1.14–2.16) and FGA exposed (OR 1.89, 95% CI 1.20–2.99) groups [ 67 ]. This study also helps support the hypothesis that prenatal exposure to SGA is involved with an increased risk of pregnancy complications related to the impairment of glucose metabolism.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Other articles also assessed FGA and SGA use during breastfeeding to better understand their effects. Typical antipsychotics are considered safe, as they do not build up to therapeutic doses in the milk [ 61 , 67 ]. However, SGA medication has varying effects.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…However, SGA medication has varying effects. Risperidone was initially believed to be unsafe for breastfeeding [ 61 , 67 ]. However, studies are now showing that it does not regularly affect the infant.…”

Section: Clinical Studiesmentioning

confidence: 99%

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Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks

Edinoff

Sathivadivel

McNeil

et al. 2022

Neurology International

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Pregnant women constitute a vulnerable population, with 25.3% of pregnant women classified as suffering from a psychiatric disorder. Since childbearing age typically aligns with the onset of mental health disorders, it is of utmost importance to consider the effects that antipsychotic drugs have on pregnant women and their developing fetus. However, the induction of pharmacological treatment during pregnancy may pose significant risks to the developing fetus. Antipsychotics are typically introduced when the nonpharmacologic approaches fail to produce desired effects or when the risks outweigh the benefits from continuing without treatment or the risks from exposing the fetus to medication. Early studies of pregnant women with schizophrenia showed an increase in perinatal malformations and deaths among their newborns. Similar to schizophrenia, women with bipolar disorder have an increased risk of relapse in antepartum and postpartum periods. It is known that antipsychotic medications can readily cross the placenta, and exposure to antipsychotic medication during pregnancy is associated with potential teratogenicity. Potential risks associated with antipsychotic use in pregnant women include congenital abnormalities, preterm birth, and metabolic disturbance, which could potentially lead to abnormal fetal growth. The complex decision-making process for treating psychosis in pregnant women must evaluate the risks and benefits of antipsychotic drugs.

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Section: Clinical Studiesmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks

Edinoff

Sathivadivel

McNeil

et al. 2022

Neurology International

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“…Risperidone secara umum diresepkan pada kondisi tertentu seperti pasien hamil dan menyusui karena lebih aman dibandingkan dengan antipsikotik lainnya baik bagi janin dan kualitas ASI. Namun dalam penggunaannya perlu dilakukan pemantauan oleh tenaga medis (Odhejo et al, 2017). Pada pasien geriatrik (lanjut usia) pemberian Risperidone menjadi lini pertama (first line) dan efektif dalam mengatasi kekambuhan pada pasien skizofrenia (Krause et al, 2018).…”

Section: Pola Peresepanunclassified

Potensi interaksi obat pada pasien skizofrenia di Rumah Sakit Jiwa Mutiara Sukma tahun 2020

Utami

Darajati²,

Puspitasari³

2022

SJP

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Schizophrenia is a chronic mental disorder characterized by distortions in thinking and behavior. Schizophrenic patients receive antipsychotic therapy (main) and non-antipsychotic (supportive) for a long time. Prescription drugs are given either single or in combination, that can possible for drug interactions. This study objective to determine the potential drug-drug interactions in schizophrenic patients. The design of this study was cross-sectional with purposive sampling technique. The data used is secondary data from the medical records of inpatient schizophrenia patients at the Mutiara Sukma Mental Hospital NTB in 2020 with a retrospective method. The sample data obtained were 109 medical records. The results showed that there were 82,2% of drug interaction cases, namely the combination of risperodone and lorazepam. The number of major interaction cases is 24,2%, moderate is 72,1% and minor is 3,6%. The high incidence of drug interactions in schizophrenic patients requires closely monitored.

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Prenatal Exposure to Antipsychotics−Handle With Caution

Yap

2022

JAMA Intern Med

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Safety and Efficacy of Antipsychotics in Pregnancy and Lactation

Cited by 6 publications

References 46 publications

Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks

Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks

Potensi interaksi obat pada pasien skizofrenia di Rumah Sakit Jiwa Mutiara Sukma tahun 2020

Prenatal Exposure to Antipsychotics−Handle With Caution

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