Safety and efficacy of bariatric surgery: Longitudinal Assessment of Bariatric Surgery

Belle, Steven H.; Berk, Paul D.; Courcoulas, Anita P.; Flum, David R.; Miles, Carolyn W.; Mitchell, James E.; Pories, Walter J.; Wolfe, Bruce M.; Yanovski, Susan Z.

doi:10.1016/j.soard.2007.01.006

Cited by 232 publications

(212 citation statements)

References 56 publications

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“…1 Multiple conditions or diseases have been shown to occur with increasing frequency with progressively severe obesity including type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea and many others. 2 The relative risk for multiple cancers among the obese has been reported and recently confirmed. 3,4 Despite all preventive and therapeutic attempts, long-term maintenance of weight loss often fails.…”

Section: Introductionmentioning

confidence: 86%

Genes and networks expressed in perioperative omental adipose tissue are correlated with weight loss from Roux-en-Y gastric bypass

et al. 2008

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Context: Gastric bypass surgery is the most commonly performed bariatric surgical procedure in the United States. Variable weight loss following this relatively standardized intervention has been reported. To date, a method for reliable profiling of patients who will successfully sustain weight loss for the long term has not been established. In addition, the mechanisms of action in accomplishing major weight loss as well as the explanation for the variable weight loss have not been established. Objective: To examine whether gene expression in perioperative omental adipose is associated with gastric bypass-induced weight loss. Design: Cross-sectional study of gene expression in perisurgical omental adipose tissues taken/available at the time of operation and total excess weight loss (EWL). Subjects: Fifteen overweight individuals who underwent Roux-en-Y gastric bypass (RYGB) surgery at the University of California Davis Medical Center (BMI: 40.6-72.8 kg/m 2 ). Measurements: Body weight before and following weight stabilization 18-42 months after surgery. Perioperative omental adipose RNA isolated from 15 subjects was hybridized to Affymetrix HG-U133A chips for 22 283 transcript expression measurements. Results: Downstream analysis identified a set of genes whose expression was significantly correlated with RYGB-induced weight loss. The significant individual genes include acyl-coenzyme A oxidase 1 (ACOX1), phosphodiesterase 3A cGMP-inhibited (PDE3A) and protein kinase, AMP-activated, beta 1 non-catalytic subunit (PRKAB1). Specifically, ACOX1 plays a role in fatty acid metabolism. PDE3A is involved in purine metabolism and hormone-stimulated lipolysis. PRKAB1 is involved in adipocytokine signaling pathway. Gene network analysis revealed that pathways for glycerolipid metabolism, breast cancer and apoptosis were significantly correlated with long-term weight loss. Conclusion: This study demonstrates that RNA expression profiles from perioperative adipose tissue are associated with weight loss outcome following RYGB surgery. Our data suggest that EWL could be predicted from preoperative samples, which would allow for informed decisions about whether or not to proceed to surgery.

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Section: Introductionmentioning

confidence: 86%

Genes and networks expressed in perioperative omental adipose tissue are correlated with weight loss from Roux-en-Y gastric bypass

et al. 2008

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“…Participants recorded the names and frequency of use of all prescribed medications taken currently using a study-specific medication form (17). Antidepressant medication use was defined as taking a medication classified as an antidepressant at least daily; antianxiety medication use was defined as taking a medication classified as an antianxiety or benzodiazepine at least daily; and psychiatric medication use was defined as use of antidepressant or antianxiety medication or a medication classified as norepinephrine reuptake inhibitor, antimanic, CNS stimulant, dibenzodiazepine, dibenzothiazepine, or phenothiazine at least daily.…”

Section: Methodsmentioning

confidence: 99%

“…The current study was part of the LABS Consortium of studies, which have been described in detail (17). The initial LABS study, (LABS-1) involved 5,050 patients and examined the short-term safety of bariatric surgery (18).…”

Section: Design Setting and Participantsmentioning

confidence: 99%

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

Kalarchian

King

Devlin

et al. 2015

Surgery for Obesity and Related Diseases

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“…The overall risk of death and other adverse outcomes for bariatric surgery are well documented, 85,86 and the plea to have this surgery performed in high-volume accredited centres has likewise been heard. 87 However, a clear distinction between perioperative medical and surgical morbidity and mortality is made in only a few publications.…”

Section: Aspiration Pneumonia 1 Pneumoniamentioning

confidence: 99%

Baseline patient profiling and three-year outcome data after metabolic surgery at a South African centre of excellence

Merwe

Fetter²,

Naidoo³

et al. 2015

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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The bariatric team at Waterfall City Hospital in Gauteng has performed 820 metabolic surgeries under the guidance of an extended team, and with comprehensive recordkeeping. Baseline profiling on more than 50 variables afforded insight into patients undergoing surgery. The available outcome data over three years were comparable with those in the documented literature. The attempted weight loss period prior to agreeing to surgery was 16-18 years. Weight loss in the overall cohort was 29% at three years, with a two-year outcome as follows: diabetes mellitus remission of 81.6% in males and 83.1% in females, full and part-hypertension resolution of 84.8% in males and 74.6% in females, hyperlipidaemia on no treatment of 76.8% in males and 72.1% in females, and sleep apnoea of 75.5% in males and 76.8% in females. Separating out the diabetic group indicated a diabetes mellitus remission of 73.9% in males and 75.1% in females at one year. Improvement in the components of metabolic syndrome was demonstrated in the total cohort. There was an worse profile and higher risk in the male patients. Similarly, higher risk was recorded in the biliopancreatic diversion-duodenal switch cohort, and there was a higher percentage of elected diabetic patients. A wide range of revision surgery was performed, with a higher complication rate (20%) experienced compared to that recorded with the primary surgeries. The morbidity data were separated into medical and surgical morbidity. Major medical morbidity was documented at 5.6% and surgical morbidity at 3.9%. Surgical morbidity in the first 250 cases was reported to be 6% vs. 2.7% in the last 570 cases. Mortality for the cohort was noted to be 0.1%.

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Safety and efficacy of bariatric surgery: Longitudinal Assessment of Bariatric Surgery

Cited by 232 publications

References 56 publications

Genes and networks expressed in perioperative omental adipose tissue are correlated with weight loss from Roux-en-Y gastric bypass

Genes and networks expressed in perioperative omental adipose tissue are correlated with weight loss from Roux-en-Y gastric bypass

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

Baseline patient profiling and three-year outcome data after metabolic surgery at a South African centre of excellence

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