2023
DOI: 10.1097/inf.0000000000004023
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Safety and Efficacy of Ceftaroline in Neonates With Staphylococcal Late-onset Sepsis: A Case Series Analysis

Arnaud Callies,
Lise Martin-Perceval,
Lise Crémet
et al.

Abstract: Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered as a compassionate treatment in 16 infants (gestational age of less than 32 weeks and less than 28 postnatal days), whose first-line treatment failed. We report 11 successes and no severe adverse drug reactions. Larger data are required to confirm these encour… Show more

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“…A recent case series describes the safe and successful use of ceftaroline as salvage therapy for preterm neonates with staphylococcal sepsis, though notably none of the 16 patients described in this series had meningitis. 6 Two prior systematic reviews of ceftaroline use, one focused on off-label use 7 and one focused on severe methicillin-resistant Staphylococcus aureus (MRSA) infections, 8 identified 4 clinical and 2 pharmacokinetic/pharmacodynamic studies of ceftaroline used for meningitis, underscoring the limited data informing the use of this agent for intracranial infections. 5 Considering the sparse clinical data informing use of ceftaroline for CNS infections, particularly in the pediatric population, we present a case report of an infant with a methicillin-resistant Staphylococcus epidermidis shunt-associated ventriculitis treated with ceftaroline in combination with vancomycin and rifampin.…”
mentioning
confidence: 99%
“…A recent case series describes the safe and successful use of ceftaroline as salvage therapy for preterm neonates with staphylococcal sepsis, though notably none of the 16 patients described in this series had meningitis. 6 Two prior systematic reviews of ceftaroline use, one focused on off-label use 7 and one focused on severe methicillin-resistant Staphylococcus aureus (MRSA) infections, 8 identified 4 clinical and 2 pharmacokinetic/pharmacodynamic studies of ceftaroline used for meningitis, underscoring the limited data informing the use of this agent for intracranial infections. 5 Considering the sparse clinical data informing use of ceftaroline for CNS infections, particularly in the pediatric population, we present a case report of an infant with a methicillin-resistant Staphylococcus epidermidis shunt-associated ventriculitis treated with ceftaroline in combination with vancomycin and rifampin.…”
mentioning
confidence: 99%