Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis

Al-Mouqdad, Mountasser M.; Eljaaly, Khalid; Abdalgader, Ayman; Alanazi, Maha; Taha, Muhammed Yassen; Alshaibani, Arwa; Asfour, Raneem S.; Khalil, Thanaa M.; Asfour, Suzan Suhail

doi:10.1016/j.jsps.2021.07.014

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…It also needs to compare the general data of SG, MG, dead group and SG, detect the peripheral venous blood of SPI before treatment (BT) and after treatment (AT), use the automatic blood analyzer to observe and analyze the changes of PCT and RDW of 4 groups of SPI. [ 12 , 13 ]…”

Section: Objects and Methodsmentioning

confidence: 99%

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Xu,

Ca,

Zhou

2024

Medicine

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It aims to study the diagnostic effect of procalcitonin (PCT) and red blood cell distribution width (RDW) in premature septicemia (PS), and to analyze the prognostic evaluation value of PCT and RDW in PS. Ninety eight septicemia premature infants (SPI) who visited the neonatal intensive care unit of our hospital from June 2019 to July 2021 were selected and met the criteria. Based on the patient’s condition and the neonatal shock score, they were separated into a severe group (SG) and a mild group (MG). There were 43 children and 55 children in the 2 groups, respectively. According to the survival status of SPI after 3 days of treatment, they were divided into a death group and a SG. It detected and analyzed the peripheral venous blood of SPI before treatment (BT) and after treatment (AT), and observed the changes of PCT and RDW. The comparison of general data between severe and mild SPI and their mothers did not have statistical significance (P > .05). The PCT of the SG was higher than that of the MG BT, on the 1st day and the 3rd day AT; The PCT BT and AT in both groups ranged from high to low on the 1st day and the 3rd day AT and BT (P < .05). The RDW in the SG were higher than those in the MG, and the RDW BT and AT in both groups were the highest on the 1st day AT; The RDW BT in the MG was higher than on the 3rd day AT, while the RDW BT in the SG was lower than on the 3rd day AT (P < .05). The optimal cutoff values for PCT on the 1st and 3rd day AT were 40.594ng/ml and 64.854ng/ml, respectively, with sensitivity of 100.0% and 100.0%, and specificity of 73.2% and 87.1% (P < .05). The optimal cutoff values for RDW on the 1st and 3rd day AT were 16.649% and 18.449%, respectively, with sensitivity of 100.0% and 100.0%, and specificity of 68.5% and 91.8% (P < .05). Monitoring the changes in PCT and RDW can promote the early diagnosis of PS and their prognosis evaluation.

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Section: Objects and Methodsmentioning

confidence: 99%

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Xu,

Ca,

Zhou

2024

Medicine

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“…The change between the beginning and end of treatment for creatinine and urea in both groups was insignificant; however, the change between the beginning and end of treatment for ALT and AST in the colistin group was statistically significant. 13 Zumrut, et al (2018) 15 showed 11 (10.5%) patients experienced nephrotoxicity. 63% of colistin-induced nephrotoxicity occurred during days 3-7.…”

Section: Patientsmentioning

confidence: 97%

Efficacy and Safety of Using Colistin in Neonates : A Systematic Review

Ratu Alicia

2023

JARMHS

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Colistin is a cationic polypeptide antibiotic that belongs to the family of polymyxins and kills bacteria by interfering with the functioning of the bacterial cell. When given intravenously, colistin has the potential to cause a number of potentially harmful side effects, the most prevalent of which is nephrotoxicity. Recent studies have shown that patients who receive therapy with intravenous colistin run a risk of developing decreased kidney function ranging from 7.5% to 18.6% of the time. This risk is higher in patients who are older. However, it is essential to keep in mind that treatment with intravenous colistin, in the same way as treatment with other nephrotoxic drugs can result in conditions such as infection, septic shock, and the failure of several organs, it is vital to keep in mind that treatment with intravenous colistin. The bactericidal actions of colistin are demonstrated to be effective against a significant proportion of Gram-negative aerobic bacilli. It wasn't until the 1950s that it was first used in the United States, but by the 1980s, intravenous versions of the drug had been phased out due to the nephrotoxicity they caused. However, due to a rise in the incidence of illnesses caused by carbapenem-resistant Gram-negative (CRGN) bacteria and a dearth of newly developed antimicrobial drugs that are active against multidrug-resistant Gram-negative germs, the effectiveness of colistin has been called into question once again. The effectiveness of colistin in newborns might range anywhere from 50 to 98 percent. In this particular research endeavor, hyponatremia was identified as a potential adverse impact.

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“…Several studies have investigated the efficacy of colistin in neonates with multidrugresistant Gram-negative (MDR GN) sepsis (Table 1) [43][44][45][46][47][48][49][50][51][52][53][54].…”

Section: Efficacy In Neonatal Sepsismentioning

confidence: 99%

Reintroduction of Legacy Antibiotics in Neonatal Sepsis: The Special Role of Fosfomycin and Colistin

Baltogianni,

Dermitzaki,

Kosmeri

et al. 2024

Antibiotics

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Neonatal sepsis is a leading cause of morbidity and mortality in neonates, particularly in low- and middle-income countries. The emergence of antimicrobial resistance is a rapidly growing global problem. A significant proportion of the pathogens that commonly cause neonatal sepsis are resistant to multiple antibiotics. Therefore, for the empirical treatment of neonatal sepsis, the repurposing of older antibiotics that are effective against multidrug-resistant pathogens is being investigated. This review aims to provide an overview of current research and experience using the repurposed antibiotics colistin and fosfomycin for the empirical treatment of neonatal sepsis. Based on current knowledge, colistin and fosfomycin may be potentially helpful for the empirical treatment of sepsis in neonates due to their efficacy against a wide range of pathogens and acceptable safety profile.

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Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis

Cited by 4 publications

References 39 publications

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Efficacy and Safety of Using Colistin in Neonates : A Systematic Review

Reintroduction of Legacy Antibiotics in Neonatal Sepsis: The Special Role of Fosfomycin and Colistin

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