Safety and Efficacy of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines During Lactation

Shook, Lydia L.; Edlow, Andrea G.

doi:10.1097/aog.0000000000005093

Cited by 10 publications

(6 citation statements)

References 78 publications

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“…The Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists recommend that lactating patients receive COVID-19 mRNA vaccines, and there is no evidence that breast milk from lactating individuals who have received COVID-19 mRNA vaccines causes harm to lactating infants. [56][57][58] However, the antibody response in this population after vaccination is also a concern. At present, some prospective cohort studies have reported the response to vaccination in such populations.…”

Section: People With Immune Deficiency Caused By Underlying Diseasesmentioning

confidence: 99%

Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review

Cai,

Chang,

Zhang

et al. 2023

Medicine

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Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around the world. Vaccines are an important means to prevent the spread of COVID-19 and reduce severe disease and mortality. Currently, different types of novel coronavirus vaccines are still being developed and improved, and the relevant vaccines that have been approved for marketing have been widely vaccinated around the world. As vaccination coverage continues to grow, concerns about the efficacy and safety of vaccines after real-world use have grown. Some clinical studies have shown that vaccine effectiveness is closely related to antibody response after vaccination. Among them, the advantages of COVID-19 messenger ribonucleic acid (mRNA) vaccine, such as better adaptability to variant strains and better immune response ability, have attracted great attention. However, different populations with different genders, ages, previous COVID-19 infection history, underlying diseases and treatments will show different antibody responses after mRNA vaccination, which will affect the protection of the vaccine. Based on this, this paper reviews the reports related severe acute respiratory syndrome Coronavirus 2 mRNA vaccines, and summarizes the effectiveness of vaccines in different populations and different disease states and looked forward to the precise vaccination strategy of the vaccine in the future.

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Section: People With Immune Deficiency Caused By Underlying Diseasesmentioning

confidence: 99%

Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review

Cai,

Chang,

Zhang

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…However, scientific research has already uncovered a complex mechanism that regulates the level of immune components in maternal milk [8,9].The children's understanding of the influence of immunizing their mothers with the COVID-19 vaccine on their safety is the most essential aspect of the mothers' immunization efficacy as a child protection strategy. It raises several problems about when daily vaccines should be administered, how long should it take between consecutive doses, and if boosters are necessary to maintain the antigen population of human milk at optimal levels [10]. In addition, researchers explore for a link between the kind and duration of antibodies in human milk and other vaccinations such as mRNA, viral vectors, and dead viruses.…”

Section: Introductionmentioning

confidence: 99%

Persistence and Efficacy of Maternal COVID-19 Vaccine-Induced Antibodies in Human Milk: A Comprehensive Meta-Analysis

Fatima,

Noor

et al. 2024

Dev. med. life sci.

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Background: The ongoing global health challenge posed by the COVID-19 pandemic has necessitated a thorough examination of vaccine efficacy, particularly the transfer of vaccine-induced immunity to infants via human milk. This meta-analysis aims to explore the persistence and efficacy of COVID-19 vaccine-induced antibodies in human milk, offering insights into passive immunity transfer to breastfeeding infants. Methods: We conducted a systematic review and meta-analysis of peer-reviewed studies published from January 2021 to December 2023, extracted from databases such as PubMed, Scopus, and Web of Science. Our focus was on studies measuring SARS-CoV-2-specific antibodies (IgA and IgG) in human milk following maternal COVID-19 vaccination. Results: Fifteen studies involving 1,200 lactating mothers who received mRNA COVID-19 vaccines were included. The analysis highlighted a consistent presence of SARS-CoV-2-specific IgA and IgG antibodies in human milk, persisting for up to six months post-vaccination. Conclusion: The results highlight the noteworthy transmission of COVID-19 antibodies via human milk, suggesting an extended duration of possible protection for neonates against SARS-CoV-2 infection. This argues in favor of immunizing nursing mothers as a preemptive public health strategy to provide their children passive immunity.

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“…Vaccine-induced immunity in pregnant and lactating women and their newborns has been widely assessed: immune transfer of neutralizing anti-Spike IgG and T-cells from the mother to the newborn occurs through the placenta and breastmilk, which foster the breastfeeding infant’s developing immune system, suggesting a potential prevention of infection [ 10 , 19 , 20 , 21 ]. Current studies show that the pregnancy trimester does not affect SARS-CoV-2 antibody production [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Anti-SARS-CoV-2 Vaccine Acceptance among Pregnant Women: Data from Outpatient Women Experiencing High-Risk Pregnancy

et al. 2023

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Pregnant women are at higher risk of severe Coronavirus disease 2019 (COVID-19) complications than non-pregnant women. The initial exclusion of pregnant women from anti-SARS-CoV-2 vaccines clinical trials has caused a lack of conclusive data about safety and efficacy for this vulnerable population. This cross-sectional study aims to define the factors related to vaccination adherence in a sample of women experiencing high-risk pregnancies. The recruited women completed a questionnaire based on the Health Belief Model. Data were analyzed to evaluate the associations between socio-demographic variables and vaccination acceptance through descriptive, univariate and multivariate logistic analyses. Among the 233 women enrolled, 65.2% (n = 152) declared that they would accept the anti-SARS-CoV-2 vaccine. Multivariate analysis showed that vaccination acceptance was associated with a high educational level (aOR = 4.52, p = 0.001), a low perception of barriers to vaccination (aOR = 1.58, p = 0.005) and the gynecologist’s advice (aOR = 3.18, p = 0.01). About a third of pregnant women are still hesitant about the anti-SARS-CoV-2 vaccine, probably because of the conflicting information received from media, friends, acquaintances and health institutions. Determining factors linked to vaccine hesitancy among pregnant women is useful for creating vaccination strategies that increase vaccination uptake.

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Safety and Efficacy of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines During Lactation

Abstract: COVID-19, coronavirus disease 2019; CDC, Centers for Disease Control and Prevention; ACOG, American College of Obstetricians and Gynecologists; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Cited by 10 publications

References 78 publications

Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review

Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review

Persistence and Efficacy of Maternal COVID-19 Vaccine-Induced Antibodies in Human Milk: A Comprehensive Meta-Analysis

Factors Associated with Anti-SARS-CoV-2 Vaccine Acceptance among Pregnant Women: Data from Outpatient Women Experiencing High-Risk Pregnancy

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